Stress Is The Primary Driver Of Tumor Spread, By Promoting Inflammation


Mar 18, 2013
USA / Europe
Ray has written so much of the effects of stress on health and specifically on how chronic stress promotes energetic dysfunction and tumor formation/growth/spread. However, up until a year ago there was very little "official" research to back up his views. This study does just that, and it shows that the chronic overactivation of the sympathetic nervous system drives up expression of VEGF, which increase angiogenesis in lymphatic vessels and thus promotes tumor growth and spread. Blocking sympathetic activation (using drugs like propranolol) or inhibiting VEGF increase (using COX inhibitors like aspirin) blocked tumor spread. Instead of propranolol, which has quite a few side effects, drugs like clonidine may be more suitable for blocking the adrenergic systemic effects of chronic stress.

Science says stress really does spread cancer in the body
Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination : Nature Communications : Nature Publishing Group

"...Norepinephrine is released from parenchymal nerve fibres in response to stress, and binds β-adrenoceptors to modulate cell function1. β-adrenoceptors are present on tumour cells and stromal cell populations in the tumour microenvironment37, 38, including inflammatory cells6. Accumulating evidence from preclinical studies suggests that chronic stress promotes cancer progression through β-adrenoceptor activation3, 4, 6, 26, 39. To investigate if β-adrenergic signalling is required for the effects of stress on intratumoural LVD, we treated mice with propranolol, a non-selective β-adrenoceptor antagonist (beta-blocker; BB) that is used clinically for the treatment of hypertension. Treatment with propranolol during MDA-MB-231 tumour development blocked chronic stress from increasing tumour LYVE-1+ LVD and reduced metastasis to lymph nodes, suggesting that reduced LVD had functional effects on tumour cell dissemination (Fig. 3a and Supplementary Table 1). Conversely, systemic activation of β-adrenoceptors with the β-adrenoceptor agonist isoproterenol was sufficient to increase intratumoural LVD and increase lymph node metastasis (Fig. 3b and Supplementary Fig. 3A) without affecting primary tumour growth (Supplementary Fig. 3B). These findings demonstrate that β-adrenoceptor signalling is sufficient to promote intratumoural LVD and is necessary for the adverse effects of stress on lymphatic vascular remodelling.

"...While chronic stress increased tumour cell VEGFC expression in primary mammary tumours in vivo (Fig. 4a), direct treatment of cultured tumour cells with the β-adrenoceptor agonist isoproterenol was insufficient to drive VEGFC expression in vitro (Fig. 4f), suggesting that a mediating factor is required for the effect of stress on tumour cell VEGFC expression in vivo. As inflammation promotes VEGFC expression and drives lymphatic remodelling15, we investigated if inflammatory pathways are linked to stress regulation of lymphatic vasculature in vivo. We first looked at expression of the inflammatory marker cyclooxygenase-2 (COX2, or PTGS2). While tumour COX2 levels were low in control mice, stress or isoproterenol elevated COX2 mRNA transcript levels (Fig. 5a and Supplementary Fig. 5A), which were strongly associated with VEGFC mRNA levels (Fig. 5b and Supplementary Fig. 5B). This is consistent with findings in other solid cancers49, 50, 51, 52, and extends observations that inflammation is linked with lymph vessel formation by identifying stress signalling as a potential driver of this relationship. To determine if inflammation is necessary for stress to modulate lymphatic architecture and lymphogenous spread, we treated control and stressed mice bearing MDA-MB-231 mammary tumours with the COX2 inhibitor celecoxib. Inhibition of COX2 activity blocked the effect of stress on tumour LYVE-1+ LVD (Fig. 5c,d) and prevented metastasis to lymph node and distant organs (Fig. 5c,d and Supplementary Fig. 5C), demonstrating a functional consequence of limiting lymphatic remodelling."


Mar 12, 2016
Screen Shot 2018-04-26 at 18.31.46.png Screen Shot 2018-04-26 at 18.29.06.png
Some good examples of the derangement of modern treatment. Note the interesting wording on that first one. It's 'healing' that makes cancer spread.


Thread starter
Mar 18, 2013
USA / Europe
Similar threads
Thread starter Title Forum Replies Date
T RP Email Advice: Mental Stress As Primary Source Of Bad Health Email Advice 30
haidut Stress May Be The Primary Cause Of Als Stress 4
youngsinatra Weaning Off SSRI - Above All Reduce Stress? Mental Issues 15
P Made one change to coffee, now no more stress Coffee 23
Stifler Extreme Stress Reaction from Coffee and Orange juice taken too close? Coffee 3
J How to Deal With Extreme Stress Mental Issues 43
Mr Joe Skin Itching (Stress, Heat, Sun) Skin 0
J Need help - huge stress response, worried what to do Supplements, Pharmaceutical Drugs 27
R Echinacoside (from cistanche) attenuates ethanol-induced oxidative stress in rat model Scientific Studies 0
N How do I increase my stress tolerance? Health 0
S-VV Anti-Peat Stress Hormones in Context Debate - Anti-Peat 15
haidut Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens Scientific Studies 2
haidut Stress-driven lipid peroxidation, inflammation re-awakens dormant cancer cells Scientific Studies 0
haidut Sexual activity and stress levels (HPA activity) may determine longevity Scientific Studies 12
L Ray Peat Interview Nov 2020 - Danny Roddy, Ray Peat, Georgi Dinkov - Bioenergetics, Thyroid, Stress, News Interviews 7
U How To Lower Stress Impact From Surgery? Cortisol, Serotonin, Histamine 0
Mito Vitamin D Supplementation During Winter: Effects On Stress Resilience D 10
haidut Low, Not High, Metabolism Creates Oxidative Stress Scientific Studies 6
U Is There A Way To Lift Weight Without Stress Response? Exercise 8
haidut Childhood Stress / Deprivation Leads To Early Puberty / Aging Scientific Studies 2
ScurveDream Change In Scenery -- Deterioration Mentally/physically -- Stress & Memories Miscellaneous Health Discussions 2
C Ulcers, H. Pylori, Malnutrition, & Plain Old Stress Digestion 55
Wabby1 Need Advice For Desperation And Stress During Pregnancy Mental Issues 18
Geronimo Stress Dysregulates Lung Function Stress 1
haidut Prenatal Stress Ups Serotonin, Which Causes Autism And Mental Disease In Offspring Scientific Studies 0
Energizer #33: NAD+/NADH, Stress, And Fatty Acids | How To Use T3, T4, And Aspirin | Histamine | Milk And Acne Danny Roddy 0
R How To Reduce Stress? Cortisol, Serotonin, Histamine 1
Lewis Acid Eugenol: Helps Reduce Loss Of Dopamine / Protects From Aluminum / Neuro-protective & Anti-stress Scientific Studies 12
koreus Tearful After Reducing Stress And Cortisol By Removing PUFA Cortisol, Serotonin, Histamine 11
ScurveDream DHEA Or Pregnenolone To Combat Possible Caffeine-induced Stress? Ask For Help or Advice 8
haidut Reducing Stress May Reverse Greying Of Hair Scientific Studies 4
Lewis Acid Long-Term L-Serine Administration Reduces Food Intake And Improves Oxidative Stress And Sirt1/NFκB S Scientific Studies 2
Pieter Stress, Coffee, Wellbutrin, Sleep And Gelatin Blood Sugar 2
L Reduction Of "vicarious" Stress But Remaining Empathic. Is That Androgenic/healthy? Scientific Studies 3
zarrin77 Theacrine Powerfully Lowers Serotonin, Increases Dopamine, And Slashes Lactic Acid From Stress Scientific Studies 16
C Intense Stress During Passage Of Food Through Large Intestine Ask For Help or Advice 128
Drareg Blood Clots & Strokes In COVID-19; ACE-2 Receptor; Oxidative Stress Viruses, Parasites, Fungus, Vaccines 12
haidut Stress Causes Grey Hair Scientific Studies 22
S.Seneff Does Waterfall Aerosol Influence Mucosal Immunity And Chronic Stress? Articles & Scientific Studies 1
haidut The Government Knows Stress Causes "learned Helplessness" / Depression Scientific Studies 2
haidut Stress (cortisol) Can Cause ANY Autoimmune Condition By Disrupting Gut Barrier Scientific Studies 0
Lewis Acid Neurobiology Of Stress And Resilience Mind, Sleep, Stress 0
Hans Erectile Dysfunction Part 3: Nitric Oxide, Oxidative Stress And Inflammation Articles & Scientific Studies 0
michael94 Isomalt To Stop Endotoxin/stress Cascade Eyes, Ears, Nose and Headaches/Migraines 0
D Constant Insatiable Hunger, Extreme Stress, And Brain Fog All For 7 Years Now Ask For Help or Advice 92
michael94 Norepinephrine Is Not A Stress Hormone Mind, Sleep, Stress 15
J My Hair, The Very Source Of Stress, Which Led To Insomnia, Etc Hair & Nails 17
Lokzo Riboflavin And Pyridoxine Restore Dopamine Levels And Reduce Oxidative Stress In Brain Of Rats Scientific Studies 0
Such_Umami Can Stress Result In Tight Muscles/inflexibility And Postural Problems? Ask For Help or Advice 8
haidut How Chronic Stress (cortisol) Causes Disease Scientific Studies 0

Similar threads