Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED


Mar 26, 2016

Pyridoxine, regardless of serotonin levels, increases production of 5-hydroxytryptophan in rat brain

Background: The aim of this study was to evaluate effects of pyridoxine and butylated hydroxytoluene (BHT) on lipid peroxidation and on levels of 5-hydroxytryptophan and serotonin.

Methods: Thirty rats (30 days of age) were used in the survey, measuring levels of lipid peroxidation (TBARS), hemoglobin, 5-hydroxytryptophan (5-HTP), and serotonin (5-HT) after intraperitoneal (i.p.) injections of 4 and 10 mg/kg/day of pyridoxine HCl during 20 days and a single dose of 2 microM/kg (440 microg) of BHT.

Results: Levels of TBARS and 5-HTP increased considerably (p <0.05) in all vitamin- and/or BHT-treated groups, and 5-HT increased partially (p <0.05) only in B(6) with or without BHT-treated groups compared with control group.

Conclusions: Results suggest that pyridoxine plays a role in tryptophan metabolism, increasing production of 5-HTP.


Perry Staltic

Dec 14, 2020
I don't take BHT with B6. Rats aren't human. I can't get to the full study to see what they did.

Perry Staltic

Dec 14, 2020
I found the full paper. It's hard for me to tell from the wording what exactly they did, but it sounds like they're used insanely high doses; like up to 10 mg/kg/day; maybe even higher. That would be 1000 mg/day for a 100 kg person.
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