25 year old female with cold urticaria for 2 years, feel unsure what to do anymore

[LLight]

Some resources about betaine.

Betaine in Inflammation: Mechanistic Aspects and Applications

Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has ...

www.ncbi.nlm.nih.gov

Betaine is a positive regulator of mitochondrial respiration - PubMed

Betaine protects cells from environmental stress and serves as a methyl donor in several biochemical pathways. It reduces cardiovascular disease risk and protects liver cells from alcoholic liver damage and nonalcoholic steatohepatitis. Its pretreatment can rescue cells exposed to toxins such as...

pubmed.ncbi.nlm.nih.gov

Betaine enhances the cellular survival via mitochondrial fusion and fission factors, MFN2 and DRP1

Betaine is a key metabolite of the methionine cycle and known for attenuating alcoholic steatosis in the liver. Recent studies have focused on the protection effect of betaine in mitochondrial regulation through the enhanced oxidative phosphorylation ...

www.ncbi.nlm.nih.gov

Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function - BMC Veterinary Research

Background The intestinal epithelial barrier, which works as the first line of defense between the luminal environment and the host, once destroyed, it will cause serious inflammation or other intestinal diseases. Tight junctions (TJs) play a vital role to maintain the integrity of the...

bmcvetres.biomedcentral.com

The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial - Journal of the International Society of Sports Nutr

Objective Betaine supplementation may enhance body composition outcomes when supplemented chronically during an exercise program. The purpose of this study was to evaluate the effect of betaine supplementation on development-related hormones, body composition, and anthropometrics in professional...

jissn.biomedcentral.com

Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats

It is widely reported how betaine addition regulates lipid metabolism but how betaine affects cholesterol metabolism is still unknown. This study aimed to investigate the role of betaine in hepatic cholesterol metabolism of Sprague-Dawley rats. Rats were ...

www.ncbi.nlm.nih.gov

Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury - PubMed

Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective properties against alcoholism. The protective properties of betaine in different other experimental models also have been documented. On the other hand, the exact cellular mechanism of cytoprotection...

pubmed.ncbi.nlm.nih.gov

Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise - PubMed

Our aim was to examine the effect of betaine supplementation on selected circulating hormonal measures and Akt muscle signaling proteins after an acute exercise session. Twelve trained men (age 19.7 ± 1.23 years) underwent 2 weeks of supplementation with either betaine (B) (1.25 g BID) or...

pubmed.ncbi.nlm.nih.gov

Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women - PubMed

High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is approximately 0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma...

pubmed.ncbi.nlm.nih.gov

Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms - PubMed

Betaine is a methyl derivative of glycine first isolated from sugar beets. Betaine consumed from food sources and through dietary supplements presents similar bioavailability and is metabolized to di-methylglycine and sarcosine in the liver. The ergogenic and clinical effects of betaine have...

pubmed.ncbi.nlm.nih.gov

Betaine supplementation is associated with the resilience in mice after chronic social defeat stress: a role of brain-gut-microbiota axis - PubMed

These findings suggest that betaine supplementation contributed to resilience to anhedonia in mice subjected to CSDS through anti-inflammation action. Therefore, it is likely that betaine could be a prophylactic nutrient to prevent stress-related psychiatric disorders.

pubmed.ncbi.nlm.nih.gov

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice

Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we analyz

diabetes.diabetesjournals.org

Investigation of betaine as a novel psychotherapeutic for schizophrenia

 

[redsun]

What biochemistry book would you recommend for the beginners? Thank you.

It would better first to actually learn about basic anatomy and physiology. Human Anatomy and Physiology 11th edition for example. And after that it depends on how much you already know. If you took chemistry in highschool it helps. But college chemistry would be better. Its harder to learn biochemistry if you know little about chemistry to begin with. So you would need to learn a basic understanding of chemistry first. Once you clear all that out, you will be able to begin to understand and grasp biochemistry research.

 

[Smitty]

Try the TMG for a few weeks and see if it improves. Thats the most direct solution so it makes sense to start there.

Most TMG supplements say to take it with the co-factors B6, Folate, and B12. Do you think this is necessary? And is 500mg a good starting point? To refresh your memory – this post is about histamine related issues, specifically urticaria.