Wrinkling Of The Palms

[jyb]

I noticed that my palms look pretty wrinkled, the fine lines type wrinkles which look like cuts. Here's an example of palm that looks similar to mine:
Picture of palm with fine lines wrinkles

Is it a normal development? I don't think so, because I think I got mine recently and not slowly over time. So I wondered if it was due to something I've been taking in the last year, as I've been experimenting over long periods of time with progesterone, small doses of aspirin, cyproheptadine... And I found some associations in the literature between palm wrinkling and some anti-inflammatory or anti-biotics drugs:

Rofecoxib-induced instant aquagenic wrinkling of the palms.
Non-steroidal anti-inflammatory drug - induced transient reactive papulotranslucent acrokeratoderma.
Unilateral aquagenic wrinkling of the palms associated with aspirin intake.

These studies concern the so-called aquagenic wrinkles - temporary and unusually prominent wrinkles from short water exposure. It's not the same as the fine line wrinkles of the picture above, although I noticed that on these studies the palms seemed to also have fine line wrinkles on top of the aquagenic wrinkles despite the very young age of the patients.

So I wonder if these fine lines too aren't associated with water exposure, otherwise why wouldn't they appear elsewhere on the body - something like poor elasticity and fragile skin that leaves permanent fine lines due to the temporary aquagenic wrinkles forming during water exposure.

 

[jyb]

Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature.

Aquagenic wrinkling of the palms is an unusual and rare dermatosis characterized by rapidly appearing edema, whitish papules, and strong wrinkling of the palms after brief immersion in water. Aquagenic wrinkling of the palms is postulated to be a result of abnormal electrolyte fluxes that result in sodium retention within epidermal keratinocytes and osmotically induced cell volume increases. A clear understanding is lacking. It is closely linked to Cystic Fibrosis and has been proposed as a test of Cystic Fibrosis but can also be induced by Cyclooxygenase (COX-2) inhibitors and Aminoglycosides. Since both aquagenic wrinkling of the palms and water immersion wrinkling occur with water immersion, are restricted to the glabrous skin, and show features of sympathetic stimulation, I hypothesize that aquagenic wrinkling of the palms is part of the spectrum of water immersion wrinkling which has recently been shown to be due to sympathetic nervous system induced vasoconstriction of the palms and digits. Furthermore I hypothesize that both conditions are restricted to the glabrous palmar skin because of unique anatomical characteristics. Palmar skin is highly porous to water and contains abundant specialized vasculature densely innervated by sympathetic nerves and has unique epidermal anchoring for gripping purposes. I postulate that in conditions with sweat electrolyte disturbances such as Cystic Fibrosis or drug induced; the normal water immersion wrinkling response is exaggerated, leading to the typical clinical features of aquagenic wrinkling of the palms.