Chronic Aspirin Ingestion Improves Spatial Learning In Adult And Aged Rats

[sweetly]

http://www.ncbi.nlm.nih.gov/pubmed/11812527

Epidemiological evidence suggests that nonsteroidal, anti-inflammatory drugs (NSAIDs) may retard the progression of Alzheimer's disease (AD). In the present study, we have chronically treated adult (4-5 months old) and aged (20+ months) rats with water adulterated with aspirin, and examined spatial learning in a swim maze. Adult rats (n=40) and aged rats (n=20) were divided into separate groups assigned to receive either normal drinking water or water with 2 mg/ml of aspirin dissolved in it. For 6 weeks, we monitored daily water and/or drug intake before testing all rats in a standard swim maze over an 8-day period. On average, each rat drank approximately 25 ml of water/day with no apparent control versus aspirin group differences. There was no effect of aspirin in young adult rats except during a visible platform trial where aspirin-treated rats performed better than controls. In contrast, aspirin markedly improved performance in the aged rats during hidden and visible platform trials. Such group differences abated by the eighth test day when all rats performed equally well. The improvements in performance were not correlated with changes in swim speeds indicating that the enhancement was not due to facilitated motor output. These data reveal that a modest, 6-week treatment regimen with aspirin in aged rats is sufficient to induce improvements in both speed of learning and strength of the learned response. We have yet to address the key question as to underlying physiological mechanism(s) that might underpin this augmented cognitive performance. Moreover, it would be useful to ascertain whether or not chronic NSAID treatment might reduce the extent of learning impairments in aged, cognitively impaired animals.

 

[NewACC]

But to replicate the effects of the study, one would need to take 5-5.5g of aspirin per day, depending on the person's weight, which by the way is close to anticancer or antidiabetic therapeutic doses of aspirin: 6-8g

 

[haidut]

But to replicate the effects of the study, one would need to take 5-5.5g of aspirin per day, depending on the person's weight, which by the way is close to anticancer or antidiabetic therapeutic doses of aspirin: 6-8g

Actually, the HED is not that high. The 2mg/ml in the drinking water used in the study equates to 2g/liter, which equates to roughly 200mg/kg bodyweight per day. The HED of that 200mg/kg bodyweight is 30mg/kg daily, so 2g-3g daily for most adults.

 

[NewACC]

@haidut

Actually, the HED is not that high. The 2mg/ml in the drinking water used in the study equates to 2g/liter, which equates to roughly 200mg/kg bodyweight per day. The HED of that 200mg/kg bodyweight is 30mg/kg daily, so 2g-3g daily for most adults.

, sorry for the offtopic, but what do you see as the benefits of combining bromocriptine with cyprohepatdin and can this reproduce the effects of microdoses of lsd? What is the difference between hydergine and bromocriptine? Haidut, I apologize for offtopic, but I really wanted to know your opinion on this matter, since you mentioned hydergin only once in the entire history of your being on the forum

 

[LeeLemonoil]

Actually, the HED is not that high. The 2mg/ml in the drinking water used in the study equates to 2g/liter, which equates to roughly 200mg/kg bodyweight per day. The HED of that 200mg/kg bodyweight is 30mg/kg daily, so 2g-3g daily for most adults.

The key is chronic intake here. 300mg is enough. The study OP clearly indicates anti-estrogenic action of aspirin, increasing neuro-androgenic action = spatial competence

 

[haidut]

@haidut

, sorry for the offtopic, but what do you see as the benefits of combining bromocriptine with cyprohepatdin and can this reproduce the effects of microdoses of lsd? What is the difference between hydergine and bromocriptine? Haidut, I apologize for offtopic, but I really wanted to know your opinion on this matter, since you mentioned hydergin only once in the entire history of your being on the forum

LSD and bromocriptine are pretty similar, minus the hallucinations, which the former induces but the latter does not. Most ergot derivatives, with the possible exception of metergoline, have some serotonin agonism properties and cyproheptadine cancels/reduces those so you get the dopamine agonism of the ergot derivative plus and anti-serotonin effects of the latter. Also, since cypro may have mild anti-dopamine effects the ergot taken with cypro helps negate/reduce the anti-dopamine effects (if any) of cypro.
Hydergine is an ergot derivative and probably similar in effects to bromocriptine. Best to use with cypro to control any possible serotonin agonism.

 

[haidut]

The key is chronic intake here. 300mg is enough. The study OP clearly indicates anti-estrogenic action of aspirin, increasing neuro-androgenic action = spatial competence

I agree, for chronic intake 300mg-500mg daily is probably enough.

 

[sugarisgreat]

LSD and bromocriptine are pretty similar, minus the hallucinations, which the former induces but the latter does not. Most ergot derivatives, with the possible exception of metergoline, have some serotonin agonism properties and cyproheptadine cancels/reduces those so you get the dopamine agonism of the ergot derivative plus and anti-serotonin effects of the latter. Also, since cypro may have mild anti-dopamine effects the ergot taken with cypro helps negate/reduce the anti-dopamine effects (if any) of cypro.
Hydergine is an ergot derivative and probably similar in effects to bromocriptine. Best to use with cypro to control any possible serotonin agonism.

Haidut-Any idea when you might get cyproheptadine back in stock at ideal labs?

 

[haidut]

Haidut-Any idea when you might get cyproheptadine back in stock at ideal labs?

Should be back in stock by Monday.

 

[sugarisgreat]

Thanks!