BestSinceDAYONE
Member
- Joined
- Apr 25, 2018
- Messages
- 495
Any thoughts on this? I've seen nothing but good things...
Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Click Here if you want to upgrade your account
If you were able to post but cannot do so now, send an email to admin at raypeatforum dot com and include your username and we will fix that right up for you.
Berberine has many great benefits, but this one side effect might actually prevent me from using or recommending it. It potently activates AMPK, which mimics a semi-fasted state, which is very non-ideal for regeneration and growth.
"The long-lasting phosphorylation of AMPK was associated with persistent elevation in AMP/ATP ratio and reduction in oxygen consumption. An increase in glycolysis was observed with a rise in lactic acid production. Berberine exhibited no cytotoxicity, and protected plasma membrane in L6 myotubes in the cell culture. These results suggest that berberine enhances glucose metabolism by stimulation of glycolysis, which is related to inhibition of glucose oxidation in mitochondria. Berberine-induced AMPK activation is likely a consequence of mitochondria inhibition that increases AMP/ATP ratio." (R)
It's also shown to inhibit complex I, which can significantly increase the production of ROS, and can then enhance lipid peroxidation (R). For optimal glucose oxidation to occur, you need optimal complex I function. As a sidenote, Metformin has also been shown to have similar side effects.
A lot of things boost AMPK, including androgens, thyroid and food components. It's just that berberine could inhibit complex I and prevent proper glucose oxidation.@Hans doesnt aspirin also boost AMPK but just not to the same extent as berberine
what about anthocyanins? (grapeseed extract which reduce iron levels)A lot of things boost AMPK, including androgens, thyroid and food components. It's just that berberine could inhibit complex I and prevent proper glucose oxidation.
Most of these compounds found in small doses in food aren't such as big problem, but once they are isolated and can be taken in large doses, then their risk for side effects increases.what about anthocyanins? (grapeseed extract which reduce iron levels)
i also heard there is an inverse relationship between mtor and ampk? most things that boost mtor lower ampk and vice versa? i think that was on the examine website but not sureA lot of things boost AMPK, including androgens, thyroid and food components. It's just that berberine could inhibit complex I and prevent proper glucose oxidation.
Most of these compounds found in small doses in food aren't such as big problem, but once they are isolated and can be taken in large doses, then their risk for side effects increases.
I'd say it's more complex than that. Thyroid can increase both mTOR and AMPK, so looking at either one alone is too reductionist.i also heard there is an inverse relationship between mtor and ampk? most things that boost mtor lower ampk and vice versa? i think that was on the examine website but not sure
Berberine has many health boosting effects one of which is to get rid of artherosclerosis....I've read it inhibits beta oxidation. (also can prevent MUFA creation in body)
it could also decrease intestinal barrier permeability to some substances.
but it's effects on blood sugar level is questionable.