JeffLubell
Member
- Joined
- May 3, 2020
- Messages
- 5
I have just begun my exploration of Ray Peat's writings and would greatly appreciate input from forum members on some ideas I have put together on the potential of high-dose thiamine to be used as adjunctive therapy for COVID-19. My hypothesis is that by stimulating the production of carbon dioxide through the inhibition of carbonic anhydrase isoenzymes thiamine could help to counter the effects of reduced blood oxygen levels by increasing minute ventilation and increasing aerobic respiration. This could help more patients to cope with COVID-19 at home, reducing the burden on hospitals. This could be particularly useful in developing countries that have few ventilators and shortages of supplemental oxygen. It could also be useful in the U.S. in the fall when the coincident emergence of COVID-19 and flu are expected to increase pressure on hospitals.
As a carbonic anhydrase inhibitor, high-dose thiamine should also have a diuretic effect which could be helpful in addressing edema. Finally, thiamine plays an important role in strengthening the body's ability to fight disease and can be deficient in those with serious illness.
The working paper is here:
Operation Thiamine -- Reducing the Need for Hospitalization of Patients with COVID-19
When I shared this working paper through Twitter, several people responded by suggesting I review Ray Peat's article on Altitude and Mortality, which I found interesting and helpful. I have incorporated a brief discussion of the potential of carbonic anhydrase inhibitors to promote aerobic metabolism in the latest version of the working paper.
I have since reviewed several additional articles by Ray Peat and plan to spend more time reading additional articles as I work to strengthen outcomes for my daughter with Ehlers-Danlos Syndrome (EDS) and several related conditions. In fact, she was the reason I discovered high-dose thiamine in the first place, as we have been using it for about two months now to treat the neurological complications of EDS with good success so far. A discussion on the Ray Peat forum was helpful for understanding the potential carbonic anhydrase inhibitory properties of thiamine, so thank you!
It goes without saying that I cannot provide medical advice and the ideas discussed in the paper are just hypotheses. I am not a doctor or a medical professional. I would be very interested in feedback on the working paper as well as connections to researchers who may be willing to conduct research into this hypothesis if it is indeed promising. If these ideas are worth testing, it would be useful to do so quickly given the severity of the illness.
Thanks in advance for your feedback!
As a carbonic anhydrase inhibitor, high-dose thiamine should also have a diuretic effect which could be helpful in addressing edema. Finally, thiamine plays an important role in strengthening the body's ability to fight disease and can be deficient in those with serious illness.
The working paper is here:
Operation Thiamine -- Reducing the Need for Hospitalization of Patients with COVID-19
When I shared this working paper through Twitter, several people responded by suggesting I review Ray Peat's article on Altitude and Mortality, which I found interesting and helpful. I have incorporated a brief discussion of the potential of carbonic anhydrase inhibitors to promote aerobic metabolism in the latest version of the working paper.
I have since reviewed several additional articles by Ray Peat and plan to spend more time reading additional articles as I work to strengthen outcomes for my daughter with Ehlers-Danlos Syndrome (EDS) and several related conditions. In fact, she was the reason I discovered high-dose thiamine in the first place, as we have been using it for about two months now to treat the neurological complications of EDS with good success so far. A discussion on the Ray Peat forum was helpful for understanding the potential carbonic anhydrase inhibitory properties of thiamine, so thank you!
It goes without saying that I cannot provide medical advice and the ideas discussed in the paper are just hypotheses. I am not a doctor or a medical professional. I would be very interested in feedback on the working paper as well as connections to researchers who may be willing to conduct research into this hypothesis if it is indeed promising. If these ideas are worth testing, it would be useful to do so quickly given the severity of the illness.
Thanks in advance for your feedback!