Aspirin may prevent and treat COVID-19

haidut

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I may get banned from social media for making a post with such a title, but I am simply reporting on what the study discovered. Namely, even a low-dose aspirin used mostly for ischemic attack (heart or brain) prevention reduced risks of SARS-CoV-2 infection by almost 30%, while also shortening the duration of infection by several days. The study did not look at whether aspirin would prevent COVID-19 exacerbations or deaths, but prior studies have already provided such evidence, so the overall picture on aspirin seems pretty clear. Namely, it is a dirt-cheap, globally available intervention, capable of preventing and treating COVID-19 while also significantly reducing the (already tiny) risk of dying of COVID-19.

FEBS Press
Low doses of aspirin may have a potential beneficial effect on COVID-19
"...The researchers analyzed data of 10,477 persons who had been tested for COVID-19 during the first COVID-19 wave in Israel from February 1, 2020 to June 30, 2020. Aspirin use to avoid the development of cardiovascular diseases in healthy individuals was associated with a 29% lower likelihood of COVID-19 infection, as compared to aspirin non-users. The proportion of patients treated with aspirin was significantly lower among the COVID-19-positive individuals, as compared to the COVID-19-negative ones. And those subjects who had been treated with aspirin were less associated with the likelihood of COVID-19 infection than those who were not. Moreover, the group observed that the conversion time of SARS-CoV-2 PCR test results from positive to negative among aspirin-using COVID-positive patients was significantly shorter, and the disease duration was two-three days shorter, depending upon the patients' pre-existing conditions."

Aspirin use may decrease ventilation, ICU admission and death in COVID-19 patients
"...Over 400 patients admitted from March to July 2020 to hospitals around the United States, including those at GW Hospital, the University of Maryland Medical Center, Wake Forest Baptist Medical Center and Northeast Georgia Health System, were included in the study. After adjusting for demographics and comorbidities, aspirin use was associated with a decreased risk of mechanical ventilation (44% reduction), ICU admission (43% reduction), and in-hospital mortality (47% reduction). There were no differences in major bleeding or overt thrombosis between aspirin users and non-aspirin users. Preliminary findings were first published as a preprint in fall 2020. Since then, other studies have confirmed the impact aspirin can have on both preventing infection and reducing risk for severe COVID-19 and death. Chow hopes that this study leads to more research on whether a causal relationship exists between aspirin use and reduced lung injury in COVID-19 patients. "Aspirin is low cost, easily accessible and millions are already using it to treat their health conditions," said Chow. "Finding this association is a huge win for those looking to reduce risk from some of the most devastating effects of COVID-19."
 

J.R.K

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A very validating study for everything Dr Peat has said about Aspirin Haidut. I know that Aspirin inhibits both Cox and Lox, so do you feel this anti inflammatory effect is the reason for its anti viral characteristic? Whereby the reduction in inflammation will allow the organisms innate immune system to then take over and identify infected cells and dispose of the virus and the infected cell.
Perhaps this is how the anti inflammatories that are used in treating COVID-19 are all so effective including the antibiotic erythromycin. If we can calm the inflammatory response the chances of the mere presence of the virus manifesting into COVID-19 might be greatly diminished, this would explain why some develop full on respitory failure while others might only have asymptomatic symptoms.
No need to respond to this, I just had an a ha moment where some of the pieces came together and needed a place to write it down.
But I am trying to figure out if ACE inhibitors are a good thing or a bad thing for this virus. I know ACE 2 is part of the angiotensin renin system which I believe is an inflammatory system where aldosterone comes from, and ACE 2 is how the virus gains access to the cells and uses the serotonin pathway to get into the lungs, and reap the whirlwind from there. I understand that Losartan raises ACE 1 and this is anti inflammatory. But I am missing the pieces as to how both fit into this scenario.
Any light that anyone could provide on this would be much appreciated,
Thanks again Haidut and all those that are in this forum,for all your tireless efforts to enlighten us who are just emerging from the dark place most of humanity sits in right now and allows us the opportunity to make informed choices on how to try to discover the actual root cause of our problems, rather than having just our symptoms treated.
 
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