AspiringSage
Member
I suspect that readers of this forum are already suspicious of statins. It is always handy to have more evidence for discussion. In this study, they administered atorvastatin 40mg daily to adults without known atherosclerotic cardiovascular disease or type 2 diabetes for ten weeks. The primary outcomes were measured insulin resistance and insulin secretion at baseline, two week intervals and conclusion of the study. The secondary outcomes were measured fasting glucose and glucose tolerance tests.
Statins Are Associated With Increased Insulin Resistance and Secretion
“Effect of Atorvastatin on Body Weight and Concentrations of Lipids, Glucose, and Insulin
Statin therapy reduced total cholesterol by 37%, LDL-C by 53%, and triglycerides by 28% (Table IV in the Data Supplement). There was no change in body weight.
Effect of Atorvastatin on Insulin Resistance
Statin treatment significantly increased insulin resistance, a co-primary outcome. Across the entire study population, the median insulin resistance (ie, SSPG) increased from 130 to 139 mg/dL (P=0.01) while the median percent increase in insulin resistance was 8% (IQR, −10% to 32%; Table; Figure 2A, Figure I in the Data Supplement). Steady-state plasma insulin decreased by 5%, but there was no significant correlation between the change in steady-state plasma insulin and the change in insulin resistance”
“Conclusions:
In individuals without type 2 diabetes, high-intensity atorvastatin for 10 weeks increases insulin resistance and insulin secretion. Over time, the risk of new-onset diabetes with statin use may increase in individuals who become more insulin resistant but are unable to maintain compensatory increases in insulin secretion.”
Citation:
Fahim Abbasi, Cindy Lamendola, et all. Statins Are Associated With Increased Insulin Resistance and Secretion, Arteriosclerosis, Thrombosis, and Vascular Biology, 2021;41:2786–2797, Originally Published 26 Aug 2021
Statins Are Associated With Increased Insulin Resistance and Secretion
“Effect of Atorvastatin on Body Weight and Concentrations of Lipids, Glucose, and Insulin
Statin therapy reduced total cholesterol by 37%, LDL-C by 53%, and triglycerides by 28% (Table IV in the Data Supplement). There was no change in body weight.
Effect of Atorvastatin on Insulin Resistance
Statin treatment significantly increased insulin resistance, a co-primary outcome. Across the entire study population, the median insulin resistance (ie, SSPG) increased from 130 to 139 mg/dL (P=0.01) while the median percent increase in insulin resistance was 8% (IQR, −10% to 32%; Table; Figure 2A, Figure I in the Data Supplement). Steady-state plasma insulin decreased by 5%, but there was no significant correlation between the change in steady-state plasma insulin and the change in insulin resistance”
“Conclusions:
In individuals without type 2 diabetes, high-intensity atorvastatin for 10 weeks increases insulin resistance and insulin secretion. Over time, the risk of new-onset diabetes with statin use may increase in individuals who become more insulin resistant but are unable to maintain compensatory increases in insulin secretion.”
Citation:
Fahim Abbasi, Cindy Lamendola, et all. Statins Are Associated With Increased Insulin Resistance and Secretion, Arteriosclerosis, Thrombosis, and Vascular Biology, 2021;41:2786–2797, Originally Published 26 Aug 2021