Saturated Fat More Stressful?

Diokine

Member
Joined
Mar 2, 2016
Messages
516
So they took healthy women and women who had a history of major depression, and fed them meals consisting of "eggs, turkey sausage, biscuits and gravy," with the difference between them being the saturated fat content. I noted the high saturated fat meal still contained 13.5 grams of oleic acid, which is pretty significant. They found these meals increased inflammatory markers after eating them. I'm not really surprised. One thing I found interesting is according to the charts, the saturated fat meals reduced inflammatory markers in women that stress prior in the day. The values associated with these markers are also barely statistically significant.

Conclusion; feed bad food to organism, organism responds with inflammation. Higher levels of saturated fat were associated with decreased inflammatory markers when the day included stressors, compared to no stress. The lower levels of inflammation in the high-oleic meal are probably related to something like lowering of inflammatory markers with intake of fish oil, essentially from the poisoning of the related metabolic pathways.
 

Giraffe

Member
Joined
Jun 20, 2015
Messages
2,955
The women received a test meal, and a couple of hours later blood samples were taken, inflammatory markers determined. The meals were high caloric, high fat, low protein and "designed to mimic common fast food meals."

Enough fat in both to trigger "metabolic endotoxemia". Possibly higher short term immune suppression in the higher PUFA meal.
That.

Related thread: Endotoxin And Fat Consumption
 

WestCoaster

Member
Joined
Aug 31, 2016
Messages
130
Location
Vancouver, BC
And herein lies the problem with the study that failed to remove all possible inflammatory markers. Eggs, turkey sausage, biscuits, and gravy, playing a game of "what doesn't belong here", should quickly identify that both biscuits and gravy are the odd ones out. Biscuits, a grainy or white flour product if you will, combined with gravy also usually made with white flour and often with milk, are both known to cause inflammation in many people by themselves. White flour products in itself are known to cause inflammation on their own, the same with dairy.

If they want to somehow group saturated fat in with inflammation, then they best not to add other known inflammatory foods in the process.
 

Mittir

Member
Joined
Feb 20, 2013
Messages
2,034
The women received a test meal, and a couple of hours later blood samples were taken, inflammatory markers determined. The meals were high caloric, high fat, low protein and "designed to mimic common fast food meals."

It is not clear to me that these are inflammatory markers. Quick google
search shows out of 4 markers 3 lowers nitric oxide synthesis.
Looks like they picked these 4 markers as inflammatory because
these compounds lower nitric oxide. In reference 16,
it is shown that in 12 week study high MUFA diet increased
nitric oxide synthase more than high SFA diet. There is
a inverse relationship between nitric oxide and SICAM-1.
In peaty world nitric oxide is not a good thing.


Atherosclerosis. 2010 Apr;209(2):533-8. doi: 10.1016/j.atherosclerosis.2009.09.023. Epub 2009 Sep 20.
Dietary fat differentially influences regulatory endothelial function during the postprandial state in patients with metabolic syndrome: from the LIPGENE study.
Perez-Martinez P1, Moreno-Conde M, Cruz-Teno C, Ruano J, Fuentes F, Delgado-Lista J, Garcia-Rios A,Marin C, Gomez-Luna MJ, Perez-Jimenez F, Roche HM, Lopez-Miranda J.
Author information

Abstract
OBJECTIVE:
To investigate whether endothelium-dependent vasomotor function and plasma levels of cellular adhesion molecules are affected by diets with different fat quantity and quality during the postprandial state in subjects with the metabolic syndrome (MetS).

METHODS:
Patients were randomly assigned to one of four isoenergetic diets distinct in fat quantity and quality: high-SFA (HSFA); high-MUFA (HMUFA) and two low-fat, high-complex carbohydrate (LFHCC) diets, supplemented with 1.24g/day of long chain n-3 PUFA (LC n-3 PUFA) or placebo for 12 weeks each. Flow-associated vasodilatation of the brachial artery and postprandial plasma levels of total nitrites, nitric oxide (NO) synthase, soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and P-selectin were assessed post-intervention.

RESULTS:
Post-intervention postprandial flow-associated vasodilatation was significantly higher after the HMUFA diet (P<0.05) compared to subjects adhering to the other three diets. Consistently, the postprandial NO synthase response significantly increased during the HMUFA compared with the HSFA and LFHCC (placebo) diets. Postprandial sICAM-1 levels were lower during the HMUFA than during the HSFA and LFHCC n-3 diets.

CONCLUSIONS:
Our data support the notion that the HMUFA diet improves postprandial endothelial cell function and decreases postprandial plasma sICAM-1 concentrations in patients with the MetS. These findings suggest that the postprandial state is important for understanding possible cardio-protective effects associated with the Mediterranean diet particularly in subject with the MetS.
 

thegiantess

Member
Thread starter
Joined
Nov 16, 2015
Messages
308
The women received a test meal, and a couple of hours later blood samples were taken, inflammatory markers determined. The meals were high caloric, high fat, low protein and "designed to mimic common fast food meals."


That.

Related thread: Endotoxin And Fat Consumption
Ooooh I forgot about that delightful thread. Went back through it and I think it explains a lot. Thanks!
 
Similar threads
Thread starter Title Forum Replies Date
Herbie Saturated fat protects alcoholics, so why not drink more? Alcohol, Tobacco, Drugs 14
_lppaiva Saturated Fat Is More Metabolically Harmful For The Human Liver Than Unsaturated Fats Or Sugars (?) Scientific Studies 5
Mito Saturated Fat Is More Metabolically Harmful For The Human Liver Than Unsaturated Fat Or Simple Sugar Articles & Scientific Studies 50
R Saturated Fat Intake Caused More Fat Gain Than PUFA Intake In Study? Ask For Help or Advice 12
ddjd why does saturated fat + carbs make me fat?? Ask For Help or Advice 53
J High Saturated Fat/Cholesterol Causes Clogged Pores/Sebaceous Filaments Skin 7
TheSir Saturated Fat Causes Heart Disease. If You Are Hypothyroid Fats 24
N Anti-Peat Saturated Fat TERRIBLE For Liver Health & Diabetes. Compared To PUFA Debate - Anti-Peat 140
M Ray Peat Is Fine With Up To 30% Of Calories From Saturated Fat Macros & Micros 47
J Saturated Fat And "Sludge Blood" Diet 14
Mito Dietary Saturated Fat And Heart Disease: A Narrative Review Articles & Scientific Studies 1
Julian Amazing "Croissant Diet" Experiment Results (Stearic Acid/Saturated Fat) Diet 603
_lppaiva Flow-mediated Dilatation Is Impaired By A High-Saturated Fat Diet But Not By A High-Carbohydrat Diet Scientific Studies 0
R #11: Testosterone, DHEA, PUFA, Libido, Aspirin, Progesterone, And Saturated Fat With Georgi Dinkov Danny Roddy 16
Razvan Saturated Fat Ask For Help or Advice 0
Mito Substituting Polyunsaturated Fat For Saturated Fat Miscellaneous Health Discussions 8
Hans Saturated Fat Diet Lowers Fasting Insulin And Can Aid With Fat Loss. Omega 6 Is Opposite Scientific Studies 1
DaveFoster Saturated Fat May Prevent Heart Failure Scientific Studies 0
AlphaCog Unsaturated Fat Protects Against Saturated Fat Induced Lipotoxicity Scientific Studies 17
Fractality Upper Limit On Saturated Fat Intake In A Single Meal And Over An Entire Day? Fats 8
Captain_Coconut Saturated Fat Allows Bacteria To Translocate Health 61
S Saturated Fat Deficiency Fats 25
haidut Saturated Fat (palmitate) Does NOT Activate TLR4 Scientific Studies 28
S Saturated Fat Improves My Verbal Fluency Ask For Help or Advice 45
A Article: "Dairy Fat May Be Saturated, But It's Not Unhealthy The Way Animal Fats Are." Dairy 1
D Improved Mental Clarity From Saturated Fat Testimonials 3
F Saturated Fat Does Not Clog The Arteries: Coronary Heart Disease Is A Chronic Inflammatory Condition Heart, Heart Rate, Blood Pressure 2
DrJ Attempt To Lose Fat Safely With Saturated Fat From Coconuts Experiments 10
Mito Saturated Fat Does Not Clog The Arteries: Coronary Heart Disease Is A Chronic In Ammatory Condition Articles & Scientific Studies 2
Colin Nordstrom De Novo Lipogenesis, Saturated Fat, And Estrogen Science 2
Dessert_All_Day The Skinny On Saturated Fat Articles & Scientific Studies 8
haidut Transdermal Delivery Of Saturated Fat Changes Systemic Fatty Acid Profile Scientific Studies 41
ShirtTieFitness Every 5% Increase Of Total Calories From Saturated Fat Associated With Higher Risk Of Mortality Fats 86
haidut CNN: Saturated Fat Does NOT Clog Your Arteries; Stress And Inflammation Do Scientific Studies 29
J Low Fat Vs Saturated Fat To Reduce PUFA Stored In Tissue: What Is The Best Strategy? Fats 6
R Saturated Fat Causing High Blood Sugar? Ask For Help or Advice 4
natedawggh New York Times Getting On The Saturated Fat Train! Scientific Studies 0
P High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despit Articles & Scientific Studies 2
haidut Fish oil (omega-3) damages liver, saturated fat protects it Scientific Studies 0
Y Here we go again: Saturated fat: guidelines to reduce coronary heart disease risk are still valid The Ray Peat Forum Lounge 3
haidut Saturated fat is getting (finally) vindicated Fats 1
P Saturated Fat And Massive Acne And Sebum Skin 13
charlie Coconut Oil, Skin Saturation, Unsaturated Fat to Saturated Coconut Oil 14
J What percentage of Saturated Fat intake is stored? Articles & Scientific Studies 24
charlie High intake of saturated fat, but not polyunsaturated fat... Articles & Scientific Studies 1
haidut PUFA Exacerbate, Saturated Fats (SFA) / Albumin / Calcium Ameliorate COVID-19 Scientific Studies 2
ken Gerald Pollack Experiment With Saturated Fats Fats 6
A Controversial Info Against Saturated Fats. Can Someone Help Making Sense Of This? Coconut Oil 11
P What Kind Of Carb Is Best When Eating Higher Saturated Fats Metabolism 3
berk Why You Stay Slimmer More Easily With Olive Oil Than With Saturated Fats Scientific Studies 116

Similar threads

Top