Badger
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- Jan 23, 2017
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Just discovered this on a web site of Alan S. Green, MD. It's a substance used for anti-aging (I attached paper referred to in next paragraph):
"Rapamycin Medicine is an inchoate specialty in the world of Alternative Medicine. It is the application of the theory and research of Mikhail Blagosklonny to clinical medicine. This theory was first articulated in 2006 in "Aging and Immortality: Quasi-programmed Senescence and Its Pharamacologic Inhibition". Clinical treatment is based upon, "Koschei the Immortal and Anti-aging Drugs", 2014. Rapamycin is the cornerstone of treatment.
In order to better explain the practice, I need to define a few terms. I separate aging into "early aging" and "late aging". Early aging is considered a disease which affects people in the 60-99 year age group and late aging is perhaps a "natural process" which effects people in the 100 to 110 age group. Early aging is driven by TOR and late aging is driven by unknown factors. Lowering TOR is about treatment of "early aging".
The theory of treatment is to slow down aging and thus slow down the development of diseases of aging, in the 60-99 year time frame. In particular, treatment is aimed at specific disease of aging and not at healthy people.
The theory is that diseases of early aging are due to hyperactive TOR and reduction of hyperactive TOR will ameliorate these diseases. In particular, the theory is that in old people, TOR is set at too high a level, a level consistent with "growth and development" appropriate for youth; treatment is to lower TOR to "maintenance" level appropriate for old people.
In a 2014 paper, it was reported that rapamycin extended median lifespan in mice, 26% females and 23% males. This is equivalent to extending median human lifespan to 100. (Miller, Harrison et. al., "Rapamycin-mediated lifespan increase in mice...", 2014}"
"We have 5 disease targets: age-related obesity, atherosclerosis, hypertension, osteoporosis, benign prostate hyperplasia. These diseases are present for a decade or more before the crash; i,e. the heart attack, stroke, onset diabetes, broken bone or need for prostate surgery. These diseases cause symptoms, signs, and laboratory findings which allow us to monitor the effects of treatment. The usual minimum age of treatment is 60."
"On one of the most remote places on planet earth a lowly soil bacteria made a poison to target yeast.The chemical target of the poison was the command and control of the yeast cell, which turned out to be the command and control of every cell on planet earth, conserved for 2 billion years of evolution. In 1965 an expedition to the island brought home the soil sample and rapamycin was discovered and noted to be an anti-fungal agent. In 1991, rapamycin led to the discovery of TOR, target of rapamycin. The discovery of TOR increased understanding of cellular biology and disease by about 10 fold. The discovery of how the cell works led to the discovery of how aging works. The discovery of how aging works led to the Koschei formula, with rapamycin as the cornerstone of that formula. Based upon empirical medicine principles, I decided rapamycin 6 mg once a week would be an aggressive treatment and 3 mg once every 10 days would be a conservative treatment. I decided to go with aggressive treatment. January 2016, I began the rapamycin-based Koschei formula with intent to take it for one year; in what could euphemistically be called a "proof-of-concept" experiment. I didn't have to wait one year; by 4 months the results were miraculous. I lost 20 pounds, my waist-line went from 38 inches to 33. I bought a pair of size 32 jeans and didn't have to wear joggers no more. I could walk 5 miles a day and ride a bike up hills without any hint of angina. Creatinine went from elevated to normal and fasting blood sugar went down. I thought I was Lazarus back from the dead. It's now over 1 year and I feel great. I've also had no mouth sores, the most common clinical side-effect. For me, rapamycin is the world's greatest medicine."
Rapamycin Treatment for Age Related Diseases
"Rapamycin Medicine is an inchoate specialty in the world of Alternative Medicine. It is the application of the theory and research of Mikhail Blagosklonny to clinical medicine. This theory was first articulated in 2006 in "Aging and Immortality: Quasi-programmed Senescence and Its Pharamacologic Inhibition". Clinical treatment is based upon, "Koschei the Immortal and Anti-aging Drugs", 2014. Rapamycin is the cornerstone of treatment.
In order to better explain the practice, I need to define a few terms. I separate aging into "early aging" and "late aging". Early aging is considered a disease which affects people in the 60-99 year age group and late aging is perhaps a "natural process" which effects people in the 100 to 110 age group. Early aging is driven by TOR and late aging is driven by unknown factors. Lowering TOR is about treatment of "early aging".
The theory of treatment is to slow down aging and thus slow down the development of diseases of aging, in the 60-99 year time frame. In particular, treatment is aimed at specific disease of aging and not at healthy people.
The theory is that diseases of early aging are due to hyperactive TOR and reduction of hyperactive TOR will ameliorate these diseases. In particular, the theory is that in old people, TOR is set at too high a level, a level consistent with "growth and development" appropriate for youth; treatment is to lower TOR to "maintenance" level appropriate for old people.
In a 2014 paper, it was reported that rapamycin extended median lifespan in mice, 26% females and 23% males. This is equivalent to extending median human lifespan to 100. (Miller, Harrison et. al., "Rapamycin-mediated lifespan increase in mice...", 2014}"
"We have 5 disease targets: age-related obesity, atherosclerosis, hypertension, osteoporosis, benign prostate hyperplasia. These diseases are present for a decade or more before the crash; i,e. the heart attack, stroke, onset diabetes, broken bone or need for prostate surgery. These diseases cause symptoms, signs, and laboratory findings which allow us to monitor the effects of treatment. The usual minimum age of treatment is 60."
"On one of the most remote places on planet earth a lowly soil bacteria made a poison to target yeast.The chemical target of the poison was the command and control of the yeast cell, which turned out to be the command and control of every cell on planet earth, conserved for 2 billion years of evolution. In 1965 an expedition to the island brought home the soil sample and rapamycin was discovered and noted to be an anti-fungal agent. In 1991, rapamycin led to the discovery of TOR, target of rapamycin. The discovery of TOR increased understanding of cellular biology and disease by about 10 fold. The discovery of how the cell works led to the discovery of how aging works. The discovery of how aging works led to the Koschei formula, with rapamycin as the cornerstone of that formula. Based upon empirical medicine principles, I decided rapamycin 6 mg once a week would be an aggressive treatment and 3 mg once every 10 days would be a conservative treatment. I decided to go with aggressive treatment. January 2016, I began the rapamycin-based Koschei formula with intent to take it for one year; in what could euphemistically be called a "proof-of-concept" experiment. I didn't have to wait one year; by 4 months the results were miraculous. I lost 20 pounds, my waist-line went from 38 inches to 33. I bought a pair of size 32 jeans and didn't have to wear joggers no more. I could walk 5 miles a day and ride a bike up hills without any hint of angina. Creatinine went from elevated to normal and fasting blood sugar went down. I thought I was Lazarus back from the dead. It's now over 1 year and I feel great. I've also had no mouth sores, the most common clinical side-effect. For me, rapamycin is the world's greatest medicine."
Rapamycin Treatment for Age Related Diseases