Rapamycin

Badger

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Just discovered this on a web site of Alan S. Green, MD. It's a substance used for anti-aging (I attached paper referred to in next paragraph):

"Rapamycin Medicine is an inchoate specialty in the world of Alternative Medicine. It is the application of the theory and research of Mikhail Blagosklonny to clinical medicine. This theory was first articulated in 2006 in "Aging and Immortality: Quasi-programmed Senescence and Its Pharamacologic Inhibition". Clinical treatment is based upon, "Koschei the Immortal and Anti-aging Drugs", 2014. Rapamycin is the cornerstone of treatment.

In order to better explain the practice, I need to define a few terms. I separate aging into "early aging" and "late aging". Early aging is considered a disease which affects people in the 60-99 year age group and late aging is perhaps a "natural process" which effects people in the 100 to 110 age group. Early aging is driven by TOR and late aging is driven by unknown factors. Lowering TOR is about treatment of "early aging".

The theory of treatment is to slow down aging and thus slow down the development of diseases of aging, in the 60-99 year time frame. In particular, treatment is aimed at specific disease of aging and not at healthy people.

The theory is that diseases of early aging are due to hyperactive TOR and reduction of hyperactive TOR will ameliorate these diseases. In particular, the theory is that in old people, TOR is set at too high a level, a level consistent with "growth and development" appropriate for youth; treatment is to lower TOR to "maintenance" level appropriate for old people.

In a 2014 paper, it was reported that rapamycin extended median lifespan in mice, 26% females and 23% males. This is equivalent to extending median human lifespan to 100. (Miller, Harrison et. al., "Rapamycin-mediated lifespan increase in mice...", 2014}"

"We have 5 disease targets: age-related obesity, atherosclerosis, hypertension, osteoporosis, benign prostate hyperplasia. These diseases are present for a decade or more before the crash; i,e. the heart attack, stroke, onset diabetes, broken bone or need for prostate surgery. These diseases cause symptoms, signs, and laboratory findings which allow us to monitor the effects of treatment. The usual minimum age of treatment is 60."

"On one of the most remote places on planet earth a lowly soil bacteria made a poison to target yeast.The chemical target of the poison was the command and control of the yeast cell, which turned out to be the command and control of every cell on planet earth, conserved for 2 billion years of evolution. In 1965 an expedition to the island brought home the soil sample and rapamycin was discovered and noted to be an anti-fungal agent. In 1991, rapamycin led to the discovery of TOR, target of rapamycin. The discovery of TOR increased understanding of cellular biology and disease by about 10 fold. The discovery of how the cell works led to the discovery of how aging works. The discovery of how aging works led to the Koschei formula, with rapamycin as the cornerstone of that formula. Based upon empirical medicine principles, I decided rapamycin 6 mg once a week would be an aggressive treatment and 3 mg once every 10 days would be a conservative treatment. I decided to go with aggressive treatment. January 2016, I began the rapamycin-based Koschei formula with intent to take it for one year; in what could euphemistically be called a "proof-of-concept" experiment. I didn't have to wait one year; by 4 months the results were miraculous. I lost 20 pounds, my waist-line went from 38 inches to 33. I bought a pair of size 32 jeans and didn't have to wear joggers no more. I could walk 5 miles a day and ride a bike up hills without any hint of angina. Creatinine went from elevated to normal and fasting blood sugar went down. I thought I was Lazarus back from the dead. It's now over 1 year and I feel great. I've also had no mouth sores, the most common clinical side-effect. For me, rapamycin is the world's greatest medicine."

Rapamycin Treatment for Age Related Diseases
 

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Luann

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It is an inducer of autophagy, including mitophagy (getting rid of old mitochondria.)
 

Nikki

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What of it's effects on blood glucose levels and insulin resistance? Are these overcome with peatarian diet? Is anyone trialing this? I am ready to trial it on myself and 8-12 dogs if I can find a reliable source. I have a suspicion that my migraines are related to fungal infection and rather hoped that treatment with a safe anti-fungal might help. That said, I don't know that the low dose indicated in the above blurb is sufficient to cure a fungal infection. I am hoping it will help.

I'd be curious to know how gluten sensitives (not celiacs, but those who can handle gluten without serious effects) respond to treatment with this substance. Anyone else want to trial it along with me and compare notes?
 
OP
Badger

Badger

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Rapamycin is really all about anti-aging, it's not about curing conditions such as fungal infections. Plus it really should not be taken by anyone under 60. If you are under 60, you should look elsewhere. For rapamycin to work in anti-aging, it HAS to be taken in low doses infrequently, typically once a week High doses are extremely risky.

What of it's effects on blood glucose levels and insulin resistance? Are these overcome with peatarian diet? Is anyone trialing this? I am ready to trial it on myself and 8-12 dogs if I can find a reliable source. I have a suspicion that my migraines are related to fungal infection and rather hoped that treatment with a safe anti-fungal might help. That said, I don't know that the low dose indicated in the above blurb is sufficient to cure a fungal infection. I am hoping it will help.

I'd be curious to know how gluten sensitives (not celiacs, but those who can handle gluten without serious effects) respond to treatment with this substance. Anyone else want to trial it along with me and compare notes?
 

Nikki

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Thanks for the input, Badger.

Only parts of me are "under 60". I have not lived 60 years, but I have premature aging. I have more wrinkles, gray hair, and arthritis than all of my relatives who are 10-25 years older, so who's to say how "old' I am?

There is a link between sunlight and mTOR production. This may explain why people who work outdoors in sunny climates have more aged skin. I am not sure if mTOR is produced and creates effects locally, or if it has a systemic effect. Do you know? Maybe this is why I am more aged? I worked oudoors through my 20's and 30's.

From what I understand, the drug is reported to help cats with autoimmune oral disease regardless of age, so I think it has an important role in quieting an overactive immune system.

I will post here if I get a chance to trial it on some canines/felines.

I'd still love to hear from anyone who has tried it.

Best,
Nikki
 
OP
Badger

Badger

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I can't answer your question without certainty. Contact Dr. Alan Green, who is in Long Island, NY and a specialist in rapamycin therapy: https://www.rapamycintherapy.com/

He seems quite accessible, as he offers an email address you can send your questions. He's says here: "The usual minimum age of treatment is 60." He also says, as regards the goals for using rapamycin: "The office plan is to slow aging to slow development of diseases of aging. We have 5 disease targets: age-related obesity, atherosclerosis, hypertension, osteoporosis, benign prostate hyperplasia. These diseases are present for a decade or more before the crash; i,e. the heart attack, stroke, onset diabetes, broken bone or need for prostate surgery." If what you have is covered by any of these things, than rapamycin may be right for you. If not, such as aged skin, which I doubt it is, then, as I said, you are best off looking to something else. But maybe you can ask Dr. Green.

Thanks for the input, Badger.

Only parts of me are "under 60". I have not lived 60 years, but I have premature aging. I have more wrinkles, gray hair, and arthritis than all of my relatives who are 10-25 years older, so who's to say how "old' I am?

There is a link between sunlight and mTOR production. This may explain why people who work outdoors in sunny climates have more aged skin. I am not sure if mTOR is produced and creates effects locally, or if it has a systemic effect. Do you know? Maybe this is why I am more aged? I worked oudoors through my 20's and 30's.

From what I understand, the drug is reported to help cats with autoimmune oral disease regardless of age, so I think it has an important role in quieting an overactive immune system.

I will post here if I get a chance to trial it on some canines/felines.

I'd still love to hear from anyone who has tried it.

Best,
Nikki
 

Dave Clark

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What of it's effects on blood glucose levels and insulin resistance? Are these overcome with peatarian diet? Is anyone trialing this? I am ready to trial it on myself and 8-12 dogs if I can find a reliable source. I have a suspicion that my migraines are related to fungal infection and rather hoped that treatment with a safe anti-fungal might help. That said, I don't know that the low dose indicated in the above blurb is sufficient to cure a fungal infection. I am hoping it will help.

I'd be curious to know how gluten sensitives (not celiacs, but those who can handle gluten without serious effects) respond to treatment with this substance. Anyone else want to trial it along with me and compare notes?
Saw your post after looking at rapamycin. Regarding the fungal infection, I would recommend ozone therapy, which worked well for me when other modalities did not, if doing it at home, you want to get over 45 gamma setting to kill fungus. I am considering the rapamycin, I am over 60, and of the mentality that nothing ventured nothing gained, but I need to do some more research. If I do use it I will post my experiences on the forum. Also, another thing that I am a fan of recommending for people with migraines, is to go to an Atlas Orthogonal practitioner and have your atlas checked for alignment. Many people have had good results, especially people who have had previous incidents of head trauma like car accidents, sports injuries, etc., but anyone, and actually most people are out of alignment according to my practitioner and what I have read. The atlas, if you are not familiar, is the very first cervical disc at the bottom of your skull. There is plenty of info on line and on YT.
 

paymanz

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Wondering what ray would say about this drug.


At what dosage they use it as anti aging drug?
 

Mauritio

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You can't really argue with 25 percent life extension , that's not too bad. And if it helps stuff like blood sugar and arteriosclerosis I'm sure there is some anti cortisol/stress action going on .
If that's true than why would you not benefit from taking it if you are under 60 ? It would mean that only 60 years and older people are stressed...
 
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I would be worried about sarcopenia when using drugs to inhibit mTor. It's through this mechanism that glycine exerts some of its beneficial effects on tissue integrity:
Glycine Is Directly Anabolic AND Anticatabolic For The Muscle

And old people already have less muscle mass. If we inhibit mTor in those people, won't they get weaker and weaker? I read a a study that showed that oleic acid improved the anabolic response of old rats to amino- acids. Perhaps mTor is elevated in old people for the same reason that the blood pressure is high in some people( as an adaptive mechanism)?

Glycine, according to Ray, is very healthy, and there are studies showing how it is androgenic, anti- cortisol, anti- serotonin, etc. I would be surprised if a substance had all these good properties and were bad for longevity( by stimulating mTor).
 

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