Came across the NIH Interventions Testing Program. Pretty interesting info. Interventions Testing Program (ITP)
Interventions shown to extend lifespan in UM-HET3 mice include;
Aspirin – Increased lifespan in males but not females (Strong et al., 2008).
Rapamycin – Increased mean and maximal lifespan in both males and females when initiated at 20 months of age (Harrison et al., 2009) and when initiated at 9 months of age (Miller et al., 2011). Females responded more robustly than males at equivalent doses; when ~ equal blood levels were achieved, response was also about equivalent in females and males (Miller et al., 2013).
17αEstradiol – Increased lifespan in males but not females, at 4.8 ppm dose (Harrison et al., 2013) and 14.4 ppm dose (Strong et al., 2016).
Acarbose (starch blocker) – Increased lifespan in both males and females, but the effects were greater in males, when initiated at 4 months of age (Harrison et al., 2013), but only males responded when initiated at 16 months of age (Strong et al., 2016).
NDGA (nordihydroguaiaretic acid) – Increased mean lifespan in males but not females (Strong et al., 2008), even at doses that gave equivalent blood levels in males and females (Harrison et al., 2013).
Protandim (herbal blend)® – Increased lifespan in males but not females (Strong et al., 2016).
Glycine – Started at 9 months. Increased lifespan in males and females (Miller et al., 2019).
Any idea why 17αEstradiol would increase lifespan in male mice? 20% weight loss was reported as well. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
Interventions shown to extend lifespan in UM-HET3 mice include;
Aspirin – Increased lifespan in males but not females (Strong et al., 2008).
Rapamycin – Increased mean and maximal lifespan in both males and females when initiated at 20 months of age (Harrison et al., 2009) and when initiated at 9 months of age (Miller et al., 2011). Females responded more robustly than males at equivalent doses; when ~ equal blood levels were achieved, response was also about equivalent in females and males (Miller et al., 2013).
17αEstradiol – Increased lifespan in males but not females, at 4.8 ppm dose (Harrison et al., 2013) and 14.4 ppm dose (Strong et al., 2016).
Acarbose (starch blocker) – Increased lifespan in both males and females, but the effects were greater in males, when initiated at 4 months of age (Harrison et al., 2013), but only males responded when initiated at 16 months of age (Strong et al., 2016).
NDGA (nordihydroguaiaretic acid) – Increased mean lifespan in males but not females (Strong et al., 2008), even at doses that gave equivalent blood levels in males and females (Harrison et al., 2013).
Protandim (herbal blend)® – Increased lifespan in males but not females (Strong et al., 2016).
Glycine – Started at 9 months. Increased lifespan in males and females (Miller et al., 2019).
Any idea why 17αEstradiol would increase lifespan in male mice? 20% weight loss was reported as well. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
