Prevention of Death in Endotoxin Shock by Glucose Administra

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Prevention of Death in Endotoxin Shock by Glucose Administration

Current interest has centered around the role of glucose metabolism in shock and trauma. The purpose of the present study was to determine the relationships of arterial blood glucose levels to hemodynamics, acid-base parameters and survival in dogs administered an LD70 E. coli endotoxin. In summary, results document progressively developing hypoglycemia in canine endotoxin shock. A positive correlation is shown to exist between endogenously maintained blood glucose levels and survival. Exogenously administered glucose which maintains blood glucose levels constant in dogs after endotoxin improves certain cardiovascular and metabolic parameters and prevents death.

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