gilson dantas
Member
@Mittir
Sorry for the simplicity of this question:
Suppose a body under stress, I mean, with the presence of estrogen and unsaturated fats in their tissues. And of course, the thyroid is impaired [low]. Now suppose this person use pregnenolone [as supplement].
The question is: if the metabolism is under stress, promoting production of estrogen, why the body will not use this "raw material" [pregnenolone] for the manufacture of more estrogen?
Yes, we know that pregnenolone is a protective hormone and estrogen is toxic, a stress hormone. They are antagonistic.
But in the metabolic sequence of manufacture of the steroidal hormones, pregnenolone is also precursor of estrogen.
Why will not happen that metabolic conversion [pregnenolone-stress hormones]? What are the metabolic impairments - generally speaking - for that malefic conversion does not occur?
Sorry for the simplicity of this question:
Suppose a body under stress, I mean, with the presence of estrogen and unsaturated fats in their tissues. And of course, the thyroid is impaired [low]. Now suppose this person use pregnenolone [as supplement].
The question is: if the metabolism is under stress, promoting production of estrogen, why the body will not use this "raw material" [pregnenolone] for the manufacture of more estrogen?
Yes, we know that pregnenolone is a protective hormone and estrogen is toxic, a stress hormone. They are antagonistic.
But in the metabolic sequence of manufacture of the steroidal hormones, pregnenolone is also precursor of estrogen.
Why will not happen that metabolic conversion [pregnenolone-stress hormones]? What are the metabolic impairments - generally speaking - for that malefic conversion does not occur?