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Omega 7's Antiinflammatory Action On Ulcerative Colitis Patients


Jan 6, 2015
palmitoleic acid , a type of fatty acid in butter and animal fat(ruminant),

Effect of Cis-palmitoleic acid (an omega-7 fatty acid) supplementation on inflammation and expression of HNF4γ, HNF4α and IL-6 in patients with ulc... - PubMed - NCBI


Cis-palmitoleic acid (Omega-7 fatty acid) is a monounsaturated fatty acid (MUFA) associated with anti-inflammatory process through specific protein interactions such as HNF4 gamma and HNF4 alpha , these two genes are related to the immune response in ulcerative colitis (UC) they may act as a mediator of anti- inflammatory action. The aim of this study was to evaluate the effect of Cis- palmitoleic acid supplementation on inflammatory activity and the expression of genes HNF4 gamma , HNF4 alpha and IL-6 in the colonic mucosa of patients with active UC.

A double-blind, randomized, placebo-controlled pilot study was conducted in 20 patients with UC. A dose of 720 mg/day of Cis-palmitoleic acid was orally administered during 8 weeks and Mayo Clinic score was used for the assessment of clinical activity in UC before and after treatment with Cis-palmitoleic acid and placebo.

A total of 20 patients with UC were randomized to receive Cis-palmitoleic acid or placebo. Significant changes in the biochemical markers of inflammation were found in UC patients before and after treatment with Cis-palmitoleic acid vs placebo such as total protein (P=0.02), hs-CRP (P=0.04) and ESR (P<0.05). The gene expression of HNF4γ and HNF4 alpha were found to be increased in the Cis-palmitoleic acid group compared to placebo group (P=0.05 and P=0.07 respectively) as well as significant reduction upon IL-6 expression in the Cis-palmitoleic acid group (P=0.005).

Cis-palmitoleic acid as co- adjuvant therapy for 8 weeks seems to decrease the inflammatory activity through the increased expression of HNF4 alpha and HNF4 gamma in patients with UC.


Feb 26, 2018
isnt palmitic acid also good for diabetes prevention ? think i have read a great article on that some time ago..

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