Niacinamide Is Both A Serotonin And Tryptophan Antagonist

Discussion in 'Scientific Studies' started by haidut, Apr 23, 2014.

  1. haidut

    haidut Member

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    I know this was discussed to a degree in another thread, but this study goes a bit further claiming that as being one of neurokynurenines niacin / niacinamide antagonizes the effects in the brain of both serotonin precursors and serotonin itself.

    http://www.ncbi.nlm.nih.gov/pubmed/15206724

    "...The following NEKY have been studied: 1-kynurenine (KYN), 3-hydroxyKYN (3HKYN), kynurenic (KYNA), anthranilic (ANT), 3-hydroxyANT (3HANT), quinolinic (QUIN), picolinic (PICA), xanthurenic (XAN), nicotinic (NIC) acids, 3-indole-pyruvate (IPA), nicotinamide (NAM). NEKY antagonize the central effects of precursors of serotonin (tryptophan and 5-HTP), and tryptamine as well."

    So maybe taking some niacinamide with large meat meals would be a good method of mitigating the tryptophan damage, similar to the recommendation from Peat to eat gelatin with the meat.
     
  2. YuriA

    YuriA New Member

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  3. Vinero

    Vinero Member

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    How is 100 mg Nicotinamide excessive? We are talking about pharmacological doses here.
     
  4. pboy

    pboy Member

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    maybe niacin is a neurotransmitter stimulator, but if you exceed your methyl capactity the body is forced to produce less neurotransmitter. That's probably why small dose niacin increases catecholamine, because the body still can handle it methyl wise, but once you exceed or deplete your methyl supply, the catecholamine level has to drop cause it cant be supported anymore

    to really control what you wanted at the time...it would take a maters precision of a dose...im pretty sure with niacin going way over can be sedating
     
  5. Suikerbuik

    Suikerbuik Member

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    From the study:

    This study found that nicotinamide load reduced the
    methyl-group pool associated with increases in plasma
    serotonin and histamine levels. The present findings,
    together with earlier results showing that nicotinamide
    load increased plasma norepinephrine but decreased its
    methylated derivatives[7], suggest that excessive
    nicotinamide could inhibit the degradation of monoamine
    neurotransmitters presumably due to methyl-group pool
    depletion
     
  6. Jenn

    Jenn Member

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    Are you using niacinamide and nicotiamide interchangeably?
     
  7. kineticz

    kineticz Member

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    So does niacinamide increase norepiphrene?
     
  8. docall18

    docall18 Member

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    So does Niacinamide actually increase or decrease serotonin?
     
  9. Dopamine

    Dopamine Member

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    From what I understand this study was performed after overnight fasting ie probaly 10+ hours without food... Niacinamide helps impair lipolysis and encourages the oxidation of glucose. If there is no glucose available (as in a fasted state) then niacinamide could potentially cause a stress reaction. Headache, watery eyes etc... I have gotten this when I push my dosage too high too quickly and/or don't provide enough sugar.
     
  10. lampofred

    lampofred Member

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    Peat has said niacinamide is very different from nicotinamide and that only the niacinamide form is helpful.
     
  11. Dave Clark

    Dave Clark Member

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    I am confused, according to Wikipedia, nicotinamide and niacinamide are the same thing. Can somebody clear that up for me?
    Nicotinamide - Wikipedia
     
  12. Mjhl85

    Mjhl85 Member

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    actually he was referring to niacin vs niacinamide
     
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