LeeLemonoil
Member
- Joined
- Sep 24, 2016
- Messages
- 4,265
At least according to Pieter Borger, a molecular biologist and specialist in genomics.
It don’t claim that his proposed mechanism of the potential „genotoxicy“ is valid. Just posting for discussion.
Pieter Borger is some sort of creationist, but his arguments are based on s cellular, genomic rationale. Taken from his Twitter account:
„The science facts are that RNA vaccins can potentially change your DNA. To understand how, we have to go a bit into genomics. Our genome contains about 50-60 thousand genes (~20 thousand protein-coding genes, the rest RNA genes). Together they make up about 25% of the genome.
13
222
344
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
In addition to that, our genome contains about 50% socalled transposable and transposed elements (TEs), including ERVs and LINEs. The latter function, among other things, as (epi)genetic switches to control when genetic programs are switched on and off.
2
59
195
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
Interestingly, ERVs and LINEs both posses genes for the enzymes "reverse transcriptase (RT)" and "integrase" (INT). The RT enzyme converts RNA into cDNA, whereas the INT enzyme can put cDNA back into the genome. They prefer doing this with viral-like RNA molecules.
2
65
185
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
Further, RNA vaccins use viruses as their genetic backbones. RNA vaccins contain viral RNAs. With thousands of copies of RT and INT genes in our genomes there is ample opportunity to put any viral RNA back into our DNA. So, RNA vaccins are potentially "genotoxic".
14
101
245
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
"Genotoxic" means that the "RNA-->cDNA-->genome integration" mechanism can lead to disturbed genetic control. In the long run, that may lead to genetic abberations and disease. It should be noted that RNA vaccins were not tested to exclude above described genotoxicy.
It don’t claim that his proposed mechanism of the potential „genotoxicy“ is valid. Just posting for discussion.
Pieter Borger is some sort of creationist, but his arguments are based on s cellular, genomic rationale. Taken from his Twitter account:
„The science facts are that RNA vaccins can potentially change your DNA. To understand how, we have to go a bit into genomics. Our genome contains about 50-60 thousand genes (~20 thousand protein-coding genes, the rest RNA genes). Together they make up about 25% of the genome.
13
222
344
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
In addition to that, our genome contains about 50% socalled transposable and transposed elements (TEs), including ERVs and LINEs. The latter function, among other things, as (epi)genetic switches to control when genetic programs are switched on and off.
2
59
195
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
Interestingly, ERVs and LINEs both posses genes for the enzymes "reverse transcriptase (RT)" and "integrase" (INT). The RT enzyme converts RNA into cDNA, whereas the INT enzyme can put cDNA back into the genome. They prefer doing this with viral-like RNA molecules.
2
65
185
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
Further, RNA vaccins use viruses as their genetic backbones. RNA vaccins contain viral RNAs. With thousands of copies of RT and INT genes in our genomes there is ample opportunity to put any viral RNA back into our DNA. So, RNA vaccins are potentially "genotoxic".
14
101
245
Pieter Borger
@BorgerPieter
·
17. Dez. 2020
"Genotoxic" means that the "RNA-->cDNA-->genome integration" mechanism can lead to disturbed genetic control. In the long run, that may lead to genetic abberations and disease. It should be noted that RNA vaccins were not tested to exclude above described genotoxicy.
