dna

Finally, some common sense coming out of the bastion of "institutionalized" science - genetics. After spending more than a century proclaiming that DNA is the core concept driving life, heredity, health and longevity medicine has now lost all hope of producing anything useful with all these...

Yet another study (published by geneticists who have a vested interest to come up with results that say otherwise) according to which for the vast majority of diseases genes explain at most 5% of the cause. So, worded differently, more than 95% of the risk of developing a particular disease is...

I posted a few threads in the past about the nefarious goals of the companies selling DNA sequencing services under the guise of discover "your ancestors" or your "disease risk". And even if the privacy aspect was well thought out and actually implemented, the very tests are next to useless with...

One of the unquestionable dogmas of genetics (up until) today is that all mitochondrial DNA of a child is inherited strictly from the mother. This firmly entrenched belief is taught as an immutable truth in medical schools and is used to justify extensive genealogical genomic tests down the...

Yet another big hit against the genetic explanation. Not only is longevity not due to genes but it can also be largely controlled by whom you associate with. Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating The Key to a Long Life Has Little...

As I mentioned several times on Danny's podcasts, the genetic approach to curing disease has not really produced much for the last 80 years so little by little the industry is shifting its focus on metabolism. However, that shift won't happen overtly by admitting metabolism is key. Rather, it...

A few months ago, I posted about the fiasco of DNA testing for disease. Basically, the false positive rate is at least 40% when it comes to testing for specific disease. Genetic Tests From Companies Do Not Match, 40% Of Results Are False Positives As a confirmation of the above disaster, now we...

One of the more controversial of Ray's statements is that chronic stress is the underlying cause of many/most chronic conditions, especially autoimmune ones. In several of his articles he describes the role tissue damage under the influence of cortisol and estrogen play in creating an immune...

Another good study showing that our lifestyle choices directly affect our future children, despite what the morons in white coats keeps repeating. It has been known for years that dads in poorer health tend to beget more sickly children but the explanation had always been genetic - i.e. the dad...

Recently, I posted a news article on the truly Orwellian push for collecting as much DNA data from as many US citizens as possible. Genetic Testing Companies Sell Your DNA, All Promise Of Privacy Is Bunk There were some angry comments in that thread that I am being overly alarmist and that...

I am sure by now everybody has heard of the much-heralded approach of the so-called "personalized medicine" - a world in which every person will be treated uniquely based on the complete analysis of their genome/DNA. From specific drugs and dosage, to interventions like radiation, diet and...

I posted a few studied in the past that argued for the primal role of RNA (and not DNA) in evolution. Not The "selfish Gene"(DNA), But RNA Be The Driver Of Evolution The geneticists like to claim that DNA still rules supreme because it was the primordial molecule that started life and its...

I have known this from the very beginning as the sole business model of these companies is the accumulation of data, its analysis and sale to third-parties who can then target you with better ads for products and services. The uber-monster of this advertising nightmare would be a Facebook +...

After decades of denial that environmentally-driven traits can be inherited, more and more prominent geneticist are calling for a major revision to the Neo-Darwinian theory of evolution. There is nothing modern about the so-called Modern Evolutionary Synthesis, and it needs to be revised or...

Whats interesting here is it's showing cortisol demethylating dna? Lowering cortisol in certain circumstance might not be ideal? High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases "Childhood stress...

As Ray said, the official story on cancer and many other conditions thought to be genetic is slowly changing. The powers that be won't admit overnight that genetics has little (if anything) to do with cancer, but the evidence for metabolic dysfunction as a cause of cancer is slowly building up...

www.ncbi.nlm.nih.gov/pubmed/16870158 Abstract The activity of the nuclear enzyme poly(ADP-ribose)polymerase-1 (E.C.2.4.2.30), which is highly activated by DNA strand breaks, is associated with the pathophysiology of both acute as well as chronic inflammatory diseases. PARP-1 overactivation...

The study looked at coffee (750ml daily, which is about 3 cups), not caffeine, even though I suspect the benefits are mostly due to caffeine and the iron-reducing effects of chlorogenic acid. http://www.ncbi.nlm.nih.gov/pubmed/24740588

http://www.malaghan.org.nz/news-and-eve ... -observed/ It looks like scientists have observed mitochondrial DNA (mDNA) transfers from healthy to tumour cells in animals for the first time. I'm not sure if the spread of the tumour means that the mDNA spread as well to healthy cells, or if the...

Hi all, Ray Peat has talked about this in some of his articles, and mentioned some specific techniques one can use to combat aging. This article talks about the relationship between the levels of methylation, aging, and cancer. As you suspect, with time methylation increases the risk of...