meatbag
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New discovery shows human cells can write RNA sequences into DNA
New discovery shows human cells can write RNA sequences into DNA--
"In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into DNA, a feat more common in viruses than eukaryotic cells."
Cells contain machinery that duplicates DNA into a new set that goes into a newly formed cell. That same class of machines, called polymerases, also build RNA messages, which are like notes copied from the central DNA repository of recipes, so they can be read more efficiently into proteins. But polymerases were thought to only work in one direction DNA into DNA or RNA. This prevents RNA messages from being rewritten back into the master recipe book of genomic DNA. Now, Thomas Jefferson University researchers provide the first evidence that RNA segments can be written back into DNA, which potentially challenges the central dogma in biology and could have wide implications affecting many fields of biology.
"Our research suggests that polymerase theta's main function is to act as a reverse transcriptase," says Dr. Pomerantz. "In healthy cells, the purpose of this molecule may be toward RNA-mediated DNA repair. In unhealthy cells, such as cancer cells, polymerase theta is highly expressed and promotes cancer cell growth and drug resistance. It will be exciting to further understand how polymerase theta's activity on RNA contributes to DNA repair and cancer-cell proliferation."
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Polθ reverse transcribes RNA and promotes RNA-templated DNA repair
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair | Science Advances--
"RP (11:35): Yeah, just out of thin air people like Fauci say “O, that isn’t how the cell works. The cell can’t integrate that into our genes, can’t reproduce that” (*). Just no evidence he’s right. For over 50 years we’ve known that our bodies have reverse transcriptase that can integrate it into our genome permanently. A group at Harvard and MIT published in-vitro research showing that in fact human cells can and do incorporate the vaccine RNA section into the genes of the cell."
ORN 4_19_21: mRNA Vaccine Dangers, Immunity, Nutrition
SARS-CoV-2 RNAreverse-transcribed and integrated into the human genome
https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1.full.pdf
