GorillaHead
Member
Check this study out guys
“Using a specific, sensitive gas chromatography-tandem mass spectrometry method, we detected high levels of glucuronidated testosterone (T) and dihydrotestosterone (DHT) in small intestinal content of mice of both sexes, whereas in the distal intestine we observed remarkably high levels of free DHT, exceeding serum levels by >20-fold. Similarly, in young adult men high levels of unconjugated DHT, >70-fold higher than in serum, were detected in feces. In contrast to mice with a normal GM composition, germ-free mice had high levels of glucuronidated T and DHT, but very low free DHT levels, in the distal intestine. These findings demonstrate that the GM is involved in intestinal metabolism and deglucuronidation of DHT and T, resulting in extremely high free levels of the most potent androgen, DHT, in the colonic content of young and healthy mice and men.”
If my review of this is correct. Deglucuronidation will lead to active dht.
High androgens are found in areas of high bacteria.
So perhaps the hairloss is due to bacteria from the gut. The endotoxin from the gut. Or the bacteria on the skin penetrating defenses because after all the hair follicle is an opening into the skin
The gut microbiota is a major regulator of androgen metabolism in intestinal contents
Androgens exert important effects both in androgen-responsive tissues and in the intestinal tract. To determine the impact of the gut microbiota (GM) on intestinal androgen metabolism, we measured unconjugated (free) and glucuronidated androgen levels ...
www.ncbi.nlm.nih.gov
“Using a specific, sensitive gas chromatography-tandem mass spectrometry method, we detected high levels of glucuronidated testosterone (T) and dihydrotestosterone (DHT) in small intestinal content of mice of both sexes, whereas in the distal intestine we observed remarkably high levels of free DHT, exceeding serum levels by >20-fold. Similarly, in young adult men high levels of unconjugated DHT, >70-fold higher than in serum, were detected in feces. In contrast to mice with a normal GM composition, germ-free mice had high levels of glucuronidated T and DHT, but very low free DHT levels, in the distal intestine. These findings demonstrate that the GM is involved in intestinal metabolism and deglucuronidation of DHT and T, resulting in extremely high free levels of the most potent androgen, DHT, in the colonic content of young and healthy mice and men.”
If my review of this is correct. Deglucuronidation will lead to active dht.
High androgens are found in areas of high bacteria.
So perhaps the hairloss is due to bacteria from the gut. The endotoxin from the gut. Or the bacteria on the skin penetrating defenses because after all the hair follicle is an opening into the skin