My take away from speed reading it is that progesterone can do the same, no?
Pregnenolone may be making things worse for me for lack of T4?
"2c) If pregnenolone doesn’t deliver adequate cortisol, then either:
……(i) you may need to supplement with both pregnenolone and biotin, since biotin is a cofactor used by adrenal enzymes to synthesize cortisol from pregnenolone
……(ii) you may need to supplement with pregnenolone and thyroid hormones T4 and T3 concurrently, since your adrenal enzymes may just be sluggish, and your hypothalamus won’t allow you to increase your thyroid T4 levels [see next section re how to do this]
……(iii) if the ab"ove two options don’t work, then you can’t help pregnenolone synthesize into cortisol, and you need to supplement with either progesterone, 17 hydroxyprogesterone or cortisol (as hydrocortisone = man made bioidentical cortisol) because your adrenal enzymes will allow one of these to synthesize into cortisol.
Progesterone will do the same. If you look at the RP Email Exchange somebody asked Ray this exact question - his response:
"Addison's disease, with adrenal cortex degeneration, can cause cortisol deficiency, in which case progesterone would compensate, but doctors often tell people they "don't have enough cortisol" without proper confirmation. [Would pregnenolone correct this?] Pregnenolone should usually do it, but progesterone is more certain if the adrenals are really destroyed."
Preg and/or prog will correct a deficiency of cortisol, but when cortisol is normal, neither will increase it further.