Irisin ameliorates male sexual dysfunction in SSRI-treated male rats

[Lokzo]

Sexual dysfunction is a common clinical condition due to different causes including the use of selective serotonin reuptake inhibitors (SSRI). Especially, SSRI paroxetine is known to cause numerous types of sexual dysfunction in men. There is growing interest in exercise as a non-pharmacological approach for the treatment of SSRI-induced sexual dysfunction. With these in mind, we investigated the effects of irisin, which is a recently detected exercise-linked hormone, on paroxetine-induced sexual dysfunction in male rats. Our findings showed that circulating irisin levels were lower in paroxetine-induced sexual dysfunction in male rats (20 mg/kg/day for 8 weeks by oral gavage than in vehicle-treated rats). In addition, results from sexual behavioral tests revealed that subcutaneous irisin perfusion (100 ng/kg/day via mini-osmotic pumps for 28 days) ameliorated sexual motivation and copulatory performance in sexually impaired male rats treated with paroxetine. The significantly reduced serum testosterone levels and α1-adrenoceptors (ADRA1A) and tyrosine hydroxylase gene (TH) expression levels in the nucleus accumbens (NAc) in paroxetine-induced sexually dysfunctioning male rats were markedly increased following irisin exposure. Similarly, the expression levels of ADRA1A and TH in the medial preoptic area (mPOA) significantly increased in male rats co-administered with paroxetine and irisin compared to the vehicle-treated male rats. These results demonstrate that irisin may be a therapeutic modality that mimics/supports the beneficial effects of exercise for improving SSRI-associated sexual dysfunction in men through increase in serum testosterone levels and increased expression of α1-adrenoceptors and TH in the NAc and mPOA associated with sexual motivation and copulatory behaviors.

Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats - PubMed

 

[aliml]

What Increases Irisin?​

1. Diet​

A high fat diet increases browning of tissue (by upregulation of UCP1). R

2. Exercise​

Irisin is dependent on muscle contraction and intensity of an exercise. R
So the more intense the exercise, the more irisin you'll produce. R
It is important to note that chronic exercise does not increase irisin levels well, but single bouts of exercise increase it significantly. So, this may explain why extensive marathon training may be detrimental to health. R
Also, it is important to know that the more fat you have, the higher your irisin levels can get after exercise. R
Irisin is also dependent of muscle mass. R
Exercise increases irisin more in lean women than lean men. R
From order of greatest irisin release to least:

• Resistance Exercise (High Intensity Strength Training, increases irisin more than endurance training) R R
• Endurance training (Increases irisin levels 2x more than aerobic exercise) R
• HIIT (High Intensity Interval Training, irisin levels increase after 6 hours for 13 hours.) R
• Acute aerobic exercise R
• Swimming (shown in rats) R
• Low Intensity Exercise R

3. Cold and Heat Thermogenesis​

• Cold vests, hats, etc
• Ice plunges
• Sauna
• Shivering R R
• Sweating

4. Hormones​

• Deficiency in Estrogen R
• Growth Hormone R R R
• Leptin R
• Myostatin Inhibition R

5. Supplements​

• CoQ10 (enhances UCP1 uncoupling to increase brown fat) R R
• Holy Basil (increased IGF1 and irisin if combined with resistance training) R

6. Drugs​

• Fenofibrate R R
• Metformin R R

7. Devices​

• Whole-Body Vibration R

The 9+ Benefits of Irisin And How To Increase It Naturally — MyBioHack | Unlock Your Maximus Potential

Irisin is an anti-obesity and anti-diabetes hormone that regulates fat tissue and blood sugar. Irisin is generated by exercise and acts as an insulin-sensitizing hormone. Irisin is so powerful that even moderately increased levels of circulating irisin potently increases energy expenditure, reduce

mybiohack.com

Other​

• Green Cardamom R
• Omega-3 fatty acids (EPA and DHA) R
• Carob R
• Taurine R