Dopamine agonists can treat anhedonia

[NewACC]

There always is. And happens often. Acting directly on receptors will mostly always cause up/down regulation. Withdrawal symptoms. Etc.

Even with indirect ways. It is a quite tricky thing.

If someone knows, please share it, but I haven't found one yet.

One thing that work wonders to rebalance dopaminergic system is avoiding completely porn, social media, netflix, computer screens in general. Difficult to apply these days but it works.

Sun and good human relationships work wonders as well. It is much easier to engage in rewarding activities if you are with other people.

Setting small, meaningful goals, help also. The meaningful part is very important. If you set a list of "todo" tasks that doesn't count. Has to be really meaningful for you, whatever it might be. If exercising is not meaningul for you setting goals of "lifting weights 3 times a week" won't work.

And takes time, short route is taking mucuna pruriens or adamantine or similar but those cause downregulation for many people.

I'm sorry, but you threw misinformation! Adamantane derivatives have always steadily increased the sensitivity to and, in principle, the transmission of dopamine itself. Amantadine, due to its dopamine-sensitizing properties, is the most talked about ADHD drug, surpassing or at least equal to methylphenidate and amphetamine

 

[NewACC]

There always is. And happens often. Acting directly on receptors will mostly always cause up/down regulation. Withdrawal symptoms. Etc.

Even with indirect ways. It is a quite tricky thing.

If someone knows, please share it, but I haven't found one yet.

One thing that work wonders to rebalance dopaminergic system is avoiding completely porn, social media, netflix, computer screens in general. Difficult to apply these days but it works.

Sun and good human relationships work wonders as well. It is much easier to engage in rewarding activities if you are with other people.

Setting small, meaningful goals, help also. The meaningful part is very important. If you set a list of "todo" tasks that doesn't count. Has to be really meaningful for you, whatever it might be. If exercising is not meaningul for you setting goals of "lifting weights 3 times a week" won't work.

And takes time, short route is taking mucuna pruriens or adamantine or similar but those cause downregulation for many people.

Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum - PubMed

Striatal glutamatergic inputs are known to participate in the modulation of dopaminergic transmission. Accordingly, the non-competitive N-methyl-D-aspartate receptor antagonists memantine and amantadine increase striatal dopamine levels, the latter being widely used in Parkinson's disease...

pubmed.ncbi.nlm.nih.gov

https://onlinelibrary.wiley.com/doi/10.1002/hup.1154