Histamine And His Role In Sleep/wake And AD(H)D

Discussion in 'Mind, Sleep, Stress' started by Kasper, Apr 28, 2014.

  1. Kasper

    Kasper Member

    Sep 11, 2013
    Wow, I've been studying histamine for some time, and it's quite interesting, but so hard ! Please correct me if I'm wrong, I'm kind of noob with biology and pubmed, and I'm sure I make mistakes all the time.

    Histamine in the hypothalamus seems to have some role in regulating sleep wake cycles. In rats it seems to be highest at one hour after the light went on, and lowest one hour after the lights turned off.

    I find this interesting as I feel dreamy during the day without medication. And this medication works by increasing histamine in the hypothalamus.
    It's been known that people with ADHD produces quite more brain waves (gamma and delta waves) that are associated with (deep) sleeping, during the day.
    I guess that maybe increasing histamine in the hypothalamus makes sure people mainly have alpha/beta brain waves that are more associated with feeling awake.

    But, if I read Ray Peat, he seem to think that histamine is little bit like estrogen. Maybe histamine in the brain and histamine from mast cells have really different functions ? I don't know. But I don't think it is bad thing to feel awake during the day ! :P