Does aspirin increase histamine release?

[dervmai]

"Aspirin enhanced histamine release from basophils via increased Syk kinase activation, and that the augmentation of histamine release by NSAIDs or FAs may be one possible cause of worsening symptoms in patients with chronic urticaria and FDEIA.""

"Aspirin augments IgE-mediated histamine release from human peripheral basophils via Syk kinase activation"

What does this mean? Aspirin increase histamine release? So should a person struggling with histamine avoid aspirin? This would suck as I really want to try aspirin.

 

[Morten]

"Aspirin enhanced histamine release from basophils via increased Syk kinase activation, and that the augmentation of histamine release by NSAIDs or FAs may be one possible cause of worsening symptoms in patients with chronic urticaria and FDEIA.""

"Aspirin augments IgE-mediated histamine release from human peripheral basophils via Syk kinase activation"

What does this mean? Aspirin increase histamine release? So should a person struggling with histamine avoid aspirin? This would suck as I really want to try aspirin.

Really curious too.....

 

[dervmai]

Really curious too.....

Can't seem to find much info on it. Hopefully someone here can chime in.