"histamine degradation can be supported by the administration of vitamin C (133) and vitamin B-6, which leads to an increase in DAO activity (14, 135)."
Histamine and histamine intolerance
Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem 1996;25:189–213.
The Antihistamine Action of Ascorbic Acid
The antihistamine action of ascorbic acid. - PubMed - NCBI
J Nutr. 1980 Apr;110(4):662-8.
Histamine and ascorbic acid in human blood.
Clemetson CA.
Abstract
Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acid level decreases. When the ascorbic acid level falls below 0.7 mg/100 ml, there is a highly significant increase in the blood histamine level. Oral administration of ascorbic acid (1 g daily for 3 days) to 11 selected volunteers resulted in a reduction of the blood histamine level in every instance.
Histamine and ascorbic acid in human blood. - PubMed - NCBI
J Am Coll Nutr. 1992 Apr;11(2):172-6.
Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis.
Johnston CS1, Martin LJ, Cai X.
Author information
Abstract
Renewed interest in the antihistamine action of ascorbic acid has emerged with the recently recognized immunosuppressive role of histamine. We examined the antihistamine effect of acute and chronic vitamin C (VC) administration and its effect on neutrophil chemotaxis in healthy men and women. In the chronic study, 10 subjects ingested a placebo during weeks 1, 2, 5 and 6, and 2 g/day of VC during weeks 3 and 4. Fasting blood samples were collected after the initial 2-week period (baseline) and at the end of weeks 4 and 6. Plasma ascorbate rose significantly following VC administration compared to baseline and withdrawal values. Neutrophil chemotaxis rose 19% (NS) during VC administration, and fell 30% after VC withdrawal, but these changes were not correlated to plasma ascorbate levels (r = 0.01). Chemotaxis was inversely correlated to blood histamine (r = -0.32, p = 0.045), and, compared to baseline and withdrawal values, histamine levels were depressed 38% following VC supplementation. Blood histamine and neutrophil chemotaxis did not change 4 hours following a single 2 g dose of ascorbic acid, although plasma ascorbate rose 150%. These data indicate that VC may indirectly enhance chemotaxis by detoxifying histamine in vivo.
Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. - PubMed - NCBI
J Nutr. 1991 Jan;121(1):126-30.
Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs.
Johnston CS1, Huang SN.
Author information
Abstract
Histamine suppresses certain immune responses, including neutrophil chemotaxis. The present study examined whether the histamine-lowering effect of ascorbate was accompanied by enhanced chemotaxis in guinea pigs. Animals were fed low ascorbate, adequate or high ascorbate diets (0.5, 2.0 or 50 mg ascorbate.100 g body wt-1.d-1) for 4 wk. Mean liver ascorbate paralleled dietary intake, and these values differed significantly. Blood histamine was significantly depressed in the high ascorbate group compared to the adequate and low ascorbate groups, and liver ascorbate was inversely correlated to blood histamine levels (r = -0.64, P less than 0.001). The random migration of neutrophils was not significantly affected by vitamin dosage. Leukocyte chemotaxis was significantly impaired in low ascorbate animals compared to that of animals with adequate ascorbate nutriture. Leukocyte chemotaxis in high ascorbate animals did not differ significantly from that in the adequate or low ascorbate groups. Furthermore, chemotaxis was significantly lower when cells extracted from animals with adequate ascorbate nutriture were incubated in low ascorbate or high ascorbate serum rather than in autologous serum. These data suggest that the histamine-lowering effect of supplemental ascorbate does not appear to enhance leukocyte chemotaxis and that serum from guinea pigs fed low or high levels of ascorbate appears to contain factors that depress chemotaxis.
Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs. - PubMed - NCBI
Int J Vitam Nutr Res. 1981;51(3):266-73.
Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy.
Sharma SC, Molloy A, Walzman M, Bonnar J.
Abstract
Levels of total ascorbic acid and histamine in the peripheral venous blood of women during the third trimester of normal pregnancy have been estimated. The results suggest that ascorbic acid acts as a modulator to control the synthesis and/or release of histamine in the body. Low levels of ascorbic acid may be essential to stimulate the synthesis and/or release of histamine while in high concentrations it may function to inhibit the release and/or to enhance the breakdown of excessive quantities of histamine in the body. Substantial evidence is now available that histamine, perhaps its nascent variety, is essential for growth and repair processes in the body. It is possible that ascorbic acid in low concentrations acts to stimulate this variety of histamine while its high concentrations act to control the levels of histamine released from storage sites which contain preformed histamine.
Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy. - PubMed - NCBI
Histamine and histamine intolerance
Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem 1996;25:189–213.
The Antihistamine Action of Ascorbic Acid
The antihistamine action of ascorbic acid. - PubMed - NCBI
J Nutr. 1980 Apr;110(4):662-8.
Histamine and ascorbic acid in human blood.
Clemetson CA.
Abstract
Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acid level decreases. When the ascorbic acid level falls below 0.7 mg/100 ml, there is a highly significant increase in the blood histamine level. Oral administration of ascorbic acid (1 g daily for 3 days) to 11 selected volunteers resulted in a reduction of the blood histamine level in every instance.
Histamine and ascorbic acid in human blood. - PubMed - NCBI
J Am Coll Nutr. 1992 Apr;11(2):172-6.
Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis.
Johnston CS1, Martin LJ, Cai X.
Author information
Abstract
Renewed interest in the antihistamine action of ascorbic acid has emerged with the recently recognized immunosuppressive role of histamine. We examined the antihistamine effect of acute and chronic vitamin C (VC) administration and its effect on neutrophil chemotaxis in healthy men and women. In the chronic study, 10 subjects ingested a placebo during weeks 1, 2, 5 and 6, and 2 g/day of VC during weeks 3 and 4. Fasting blood samples were collected after the initial 2-week period (baseline) and at the end of weeks 4 and 6. Plasma ascorbate rose significantly following VC administration compared to baseline and withdrawal values. Neutrophil chemotaxis rose 19% (NS) during VC administration, and fell 30% after VC withdrawal, but these changes were not correlated to plasma ascorbate levels (r = 0.01). Chemotaxis was inversely correlated to blood histamine (r = -0.32, p = 0.045), and, compared to baseline and withdrawal values, histamine levels were depressed 38% following VC supplementation. Blood histamine and neutrophil chemotaxis did not change 4 hours following a single 2 g dose of ascorbic acid, although plasma ascorbate rose 150%. These data indicate that VC may indirectly enhance chemotaxis by detoxifying histamine in vivo.
Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. - PubMed - NCBI
J Nutr. 1991 Jan;121(1):126-30.
Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs.
Johnston CS1, Huang SN.
Author information
Abstract
Histamine suppresses certain immune responses, including neutrophil chemotaxis. The present study examined whether the histamine-lowering effect of ascorbate was accompanied by enhanced chemotaxis in guinea pigs. Animals were fed low ascorbate, adequate or high ascorbate diets (0.5, 2.0 or 50 mg ascorbate.100 g body wt-1.d-1) for 4 wk. Mean liver ascorbate paralleled dietary intake, and these values differed significantly. Blood histamine was significantly depressed in the high ascorbate group compared to the adequate and low ascorbate groups, and liver ascorbate was inversely correlated to blood histamine levels (r = -0.64, P less than 0.001). The random migration of neutrophils was not significantly affected by vitamin dosage. Leukocyte chemotaxis was significantly impaired in low ascorbate animals compared to that of animals with adequate ascorbate nutriture. Leukocyte chemotaxis in high ascorbate animals did not differ significantly from that in the adequate or low ascorbate groups. Furthermore, chemotaxis was significantly lower when cells extracted from animals with adequate ascorbate nutriture were incubated in low ascorbate or high ascorbate serum rather than in autologous serum. These data suggest that the histamine-lowering effect of supplemental ascorbate does not appear to enhance leukocyte chemotaxis and that serum from guinea pigs fed low or high levels of ascorbate appears to contain factors that depress chemotaxis.
Effect of ascorbic acid nutriture on blood histamine and neutrophil chemotaxis in guinea pigs. - PubMed - NCBI
Int J Vitam Nutr Res. 1981;51(3):266-73.
Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy.
Sharma SC, Molloy A, Walzman M, Bonnar J.
Abstract
Levels of total ascorbic acid and histamine in the peripheral venous blood of women during the third trimester of normal pregnancy have been estimated. The results suggest that ascorbic acid acts as a modulator to control the synthesis and/or release of histamine in the body. Low levels of ascorbic acid may be essential to stimulate the synthesis and/or release of histamine while in high concentrations it may function to inhibit the release and/or to enhance the breakdown of excessive quantities of histamine in the body. Substantial evidence is now available that histamine, perhaps its nascent variety, is essential for growth and repair processes in the body. It is possible that ascorbic acid in low concentrations acts to stimulate this variety of histamine while its high concentrations act to control the levels of histamine released from storage sites which contain preformed histamine.
Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy. - PubMed - NCBI
