Nestito
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- Dec 3, 2016
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How do PUFAs lower cholesterol and why would high cholesterol be a sign of hypothyroidism (PUFA suppressed) if they lower it?
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Do PUFAs lower cholesterol?
PUFA only lowers blood levels of cholesterol not total body tissue cholesterol. PUFA's esterfy (join with a fatty acid) cholesterol. The liver perceives this as a decrease in "free" cholesterol (even though bound cholesterol increased in body tissues). When the liver thinks that its pool of free cholesterol is too small it upregulates LDL receptors which brings more cholesterol in from the blood, this lowers blood levels of cholesterol.How do PUFAs lower cholesterol and why would high cholesterol be a sign of hypothyroidism (PUFA suppressed) if they lower it?
PUFA only lowers blood levels of cholesterol not total body tissue cholesterol. PUFA's esterfy (join with a fatty acid) cholesterol. The liver perceives this as a decrease in "free" cholesterol (even though bound cholesterol increased in body tissues). When the liver thinks that its pool of free cholesterol is too small it upregulates LDL receptors which brings more cholesterol in from the blood, this lowers blood levels of cholesterol.
High cholesterol can be a sign of low metabolism because cholesterol should be used by the liver for making bile acids and also for hormone synthesis. If you are hypothyroid the rate of conversion to bile and hormones will be slow. This will slow LDL receptor activity and cholesterol will accumulate in the blood.