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Does Ray Peat Actually Say Here That High LDL Can Be Bad?

Discussion in 'Cholesterol' started by Mufasa, Apr 13, 2018.

  1. Mufasa

    Mufasa Member

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    From: Cholesterol, longevity, intelligence, and health.
    So in an ideal situation, LDL is low because it is constantly turned into pregnenolone through the action of thyroid and using vitamin A. But when LDL is high and there are a lot of free radicals (for example, because of a high PUFA burden), than high LDL can cause the formation of cholesterol deposits in arteries, which increase the risk of CVD.

    Do I understand this correctly? @haidut

    I'm asking this because my girlfriend wants me to inform her father about cholesterol (who has high BP and athersclerosis).
    I'm afraid that if I explain him the benefits about cholesterol.
    He may stop his cholesterol lowering medication.
    But if he then for example continues eating french fries, fried in sunflower oil, his risk of dying of CVD may actually become higher.
     
  2. Mito

    Mito Member

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    I found this video helpful to understand LDL and PUFA’s role in CVD.

     
  3. Birdie

    Birdie Member

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    Thank you.
     
  4. OP
    Mufasa

    Mufasa Member

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    Thanks for the video @Mito.

    It is interesting, he believes that LDL in high amounts is contributing to atherosclerosis.
    Mainly because if you have more LDL, than the body can use than it will stay too long in the blood.
    And since the membrane of LDL consist of PUFA's, and the blood is high in things that could oxidize that PUFA,
    at some point the LDL will be damaged which initiates the process atherosclerosis.

    I wonder if PUFA's effect of lowering LDL, is because it brings LDL from the blood to your arteries.
     
  5. Mito

    Mito Member

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    A healthy metabolism (thyroid) should keep LDL receptor activity high. I’d assume a low PUFA diet would reduce the amount of PUFA in the LDL membrane further reducing the chance of oxidation.

    It’s because PUFA esterifies cholestrol so it moves from the blood to other tissues (including arteries).

    You might like this podcast as it explains the ideas in detail. https://chrismasterjohnphd.com/2017/03/19/what-to-do-about-high-cholesterol/

    I’d also suggest reading some of @Travis posts about CVD. He believes adequate Vitamin C is crucial to prevent the arterial damage in the first place so you don’t have to worry so much about the LDL particles repairing the damage and getting oxidized (at least that’s my understanding of his thoughts). Here is one of his posts on the subject.
    The Relationship Between Serum Level Of Manganese And Severity Of Coronary Atherosclerosis
     
  6. haidut

    haidut Member

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    Your arteries, liver and muscles, thus causing NAFLD and other issues.
     
  7. Travis

    Travis Member

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    Not quite! I see the vitamin C as doing two things: increasing procollagen synthesis and lowering Lp(a), both of which it's been shown to do. Most fundamentally, it repairs the damage nearly as fast as it can be created while keeping the artery wall with a high zeta potential—nothing will bind to it. The liver downregualtes Lp(a) because it knows it's will not be needed, an adhesive protein (Lp(a)) which is the 'backup plan' for keeping arterial wall the in the absence of vitamin C.

    This is the Pauling explanation and it fully complies with all evidence that I've seen; but since it's not really concerned about what causes the damage in the first place, is does not actually contradict all of the others (just some of them): High high blood pressure, ω−6 fatty acids, and reactive nitrogen species can still all be risk factors under the Pauling paradigm: an explanation more concerned more about the molecular mechanics of post-damage events.

    A person could accept the Pauling explanation while adding to it, perhaps forming a ω−6-Pauling chimera hypothesis which goes further to explain the whole event.
     
  8. benaoao

    benaoao Member

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    This podcast from Masterjohn is pretty much the best recap on cholesterol, in a layman way, free from dogma and bias. Very very good. As a pharmacist myself, I wish we had lectures from this man.

    Quoting what could be helpful for anyone with a total cholesterol / HDL ratio over 4 (3 being my target as well)

    Regarding inflammation, I’d also think of chronical acidity from the diet - debated elsewhere in this forum (the topic about Salt - sulfur aminos - phosphate in junk food - low potassium low magnesium diets)

    I wouldn’t take lipids too lightly, this basic test is paramount.
     
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