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Choline Associated Hypersexuality In A 79-year-old Man

Discussion in 'Scientific Studies' started by Lokzo, Nov 30, 2018.

  1. Lokzo

    Lokzo Member

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  2. DaveFoster

    DaveFoster Member

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    I gave alpha GPC and ashwagandha to a friend, and he suffered from an extreme, uncontrollable surge in his libido. Cholinergic drugs in general can cause irritability and aggressive sexual impulses.
     
  3. Sourdoughbanana

    Sourdoughbanana Member

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    don't mind me as I'm discreetly ordering some for my GF
     
  4. Spondive

    Spondive Member

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    Lol
     
  5. OP
    Lokzo

    Lokzo Member

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    That is crazy.

    I will get a few friends to experiment with this (including myself).

    Any idea the mechanisms/pathway behind the irritability/aggressive sexual impulses?
     
  6. OP
    Lokzo

    Lokzo Member

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    Haha!!

    Please report back how that experiment goes (In G-rated detail) :tearsofjoy:
     
  7. Sourdoughbanana

    Sourdoughbanana Member

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    What a story. Note that 1200mg alpha GPC is about 500mg of choline or ~4 eggs per day (I don’t eat lots of meat), but those eggs are a good amount of arachidonic acid. Plus I’m not not too sure about dietary choline crossing the brain blood barrier
     
  8. DaveFoster

    DaveFoster Member

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    The actions of the hormone estrogen tie in very closely with the cholinergic system, where both tend to depress metabolism. Estrogen can cause hypersexuality and aggression, and activation of the cholinergic system increases the activity of estrogen. Acetylcholine itself can cause many of the textbook symptoms of the "fight-or-flight" response; it decreases the appetite and promotes a state of intense focus and feelings of capability, themselves supportive of the quest for food. Under the influence of acetylcholine, the salivary glands secrete saliva in preparation for a meal. Blockade of cholinergic receptors significantly increases the appetite.

    Histamine has many overlapping effects with estrogen, where histamine in particular increases wakefulness. For example, the drug "modafinil" treats narcolepsy, or excessive daytime sleepiness, and it has a histamine-like effect; it often causes an allergic reaction, specifically a rash as a side effect. Estrogen, acetylcholine and histamine all promote aggression, focus and wakefulness respectively, all components of a "type A" workaholic personality, and itself an archetype idealized in the West.
     
  9. Anders86

    Anders86 Member

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    Supplementing Choline seem to make people vulnerable to depression. There are tons of anecdotes in the nootropic communities of people experiences good effect at first but then experiencing anger and depression. I personally experienced this with Alpha GPC, CDP Choline and DMAE and I have MTHFR(more need of choline). I was on a Leangains diet, not optimal diet. I guess dose make the "poison", but I never did big dosages.
     
  10. Sourdoughbanana

    Sourdoughbanana Member

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    if you had a deficiency, and supplementing addressed the problem, then it makes sense that going overboard isn't going to help at all

    "more is less" should be a mantra when it comes to supplements
     
  11. Anders86

    Anders86 Member

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    There is also direct sideeffects with choline supplementation as Tmao production.

    I was taking dosages lower than recomended.
     
  12. Sourdoughbanana

    Sourdoughbanana Member

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    recommended doses are usually bunk and excessive so that you end up buying more and more often

    maybe you didn't have a need for acetylcholine in the first place, or very minimal
     
  13. Anders86

    Anders86 Member

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    I just Examine.com as dosing source.
     
  14. Sourdoughbanana

    Sourdoughbanana Member

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    yeah well Examine, that's the typical one-size-fit-all website.

    Tapering off the supplement when you don't feel the good effects anymore is paramount. I'm a pharmacist and people never listen when I say that their beloved pill from Amazon has cumulative effects over time, far more often than not, and that requires a degree of body awareness meaning cycling on and off is needed. I see this all the time with people who self medicate OTC. Even worse on forums when people self medicate nootropics, or much more potent pharmaceuticals and then blame Big Industry for the side effects. Granted, the recommended doses are insane for most people who "just want to feel better". This society is stuck in a never ending quest for the magic pill and then people are unhappy when stuff goes wrong.

    Anyone who pops pills MUST listen to their body and zoom out before making conclusions. The appeal to authority involving other "forum people" is unfortunately insufficient - always assume that people don't know what they're doing, and would much rather blame it on some bogeyman. The icing on the cake being steroid/hormone users who would never ever double check their own behavior.
     
  15. Anders86

    Anders86 Member

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    I see what you mean and I`m usually the careful one. Choline is a daily required nutrient, making it a bit more "careless" supplement compared to a steroid/hormone. I think we are saying the same thing though, that it is a supplement to take seriously. But even though it is a supplement to take seriously it is also a supplement with side effects. TMAO production, raises HGH, lipolysis and iron absorption. And there are probably more.
     
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