Beta Alanine Reduces Serotonin Levels In The Brain

Discussion in 'Scientific Studies' started by haidut, Sep 1, 2015.

Tags:
  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,831
    Gender:
    Male
    Location:
    USA / Europe
    Animal study, but worth reviewing. The dose of beta alanine was not that high (2.5g - 3g for a human) and the reduction of serotonin was probably the cause of the anxiolytic effect of beta alanine in rats, even though only levels of serotonin in hypothalamus were reduced.
    If someone has access to the full study, please forward along so I can take a better look.

    http://www.ncbi.nlm.nih.gov/pubmed/20099004

    "...In contrast, beta-alanine-supplemented diet decreased the concentration of 5-hydroxyindoleacetic acid, a major metabolite of serotonin, in the hypothalamus. Beta-alanine-supplemented diet also increased carnosine (beta-alanyl-L: -histidine) concentration in the cerebral cortex and hypothalamus, and brain-derived neurotrophic factor concentration in the hippocampus. These results suggested that taurine-supplemented diet had an antidepressant-like effect and beta-alanine-supplemented diet had an anxiolytic-like effect."

    Another study showing dopamine-sparing effects of beta alanine:
    http://www.ncbi.nlm.nih.gov/pubmed/99490
     
  2. aguilaroja

    aguilaroja Member

    Joined:
    Jul 24, 2013
    Messages:
    835
    A recent study observed beta-alanine supplementation reduced PTSD-like behavior in rats. However, if the action is to increase a nerve growth factor, BDNF, it may questionable whether this is an optimal metabolic function.

    http://www.ncbi.nlm.nih.gov/pubmed/25758106
    β-Alanine supplemented diets enhance behavioral resilience to stress exposure in an animal model of PTSD.
    Hoffman JR1, Ostfeld I, Stout JR, Harris RC, Kaplan Z, Cohen H.
    Amino Acids. 2015 Jun;47(6):1247-57. doi: 10.1007/s00726-015-1952-y. Epub 2015 Mar 11.
    "BA supplementation in rats increased brain carnosine concentrations and resulted in a reduction in PTSD-like behavior, which may be mediated in part by maintaining BDNF expression in the hippocampus."


    http://raypeat.com/articles/other/auton ... tems.shtml

    Endocrinology 2000 Mar;141(3):1059-72. An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the rat. Lara HE, Dissen GA, Leyton V, Paredes A, Fuenzalida H, Fiedler JL, Ojeda SR.
    "The results indicate that the hyperactivation of ovarian sympathetic nerves seen in EV-induced PCO is related to an overproduction of NGF and its low affinity receptor in the gland. They also suggest that activation of this neurotrophic-neurogenic regulatory loop is a component of the pathological process by which EV induces cyst formation and anovulation in rodents."

    http://raypeat.com/articles/aging/madcow.shtml

    "J Neural Transm. 2001;108(2):221-30. Difference in toxicity of beta-amyloid peptide with aging in relation to nerve growth factor content in rat brain. Fukuta T, Nitta A, Itoh A, Furukawa S, Nabeshima T. “NGF levels in the hippocampus were increased only in adult rats. These results suggest that Abeta is toxic only in the matured adult brain, and that the mechanism of toxicity is related to NGF synthesis."
     
  3. CoolTweetPete

    CoolTweetPete Member

    Joined:
    Aug 5, 2015
    Messages:
    727
    Occupation:
    Telecommunications / Health & Fitness
    Location:
    San Francisco
    Very interesting. Do you folks use Beta-Alanine / know of a good brand? I was using Natural Stacks BCAA's for a while but they're very pricey as they boast good sourcing.

    Would prefer to just take Beta Alanine at this point.

    http://www.naturalstacks.com/products/natural-bcaas
     
  4. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,831
    Gender:
    Male
    Location:
    USA / Europe
    Thanks, I thought about that as well. BDNF is elevated form endurance exercise and some types of stress. So, beta alanine may not be optimal for everybody. But Ray talks about it favorably in one of his articles and it also has proven ergogenic benefits (alone or in combination with baking soda, creatine, etc). Since caffeine lowers BDNF maybe it can be combined with beta alanine for extra ergogenic benefit and reduced jitteriness (beta alanine is a GABA agonist like taurine and glycine).
     
  5. cantstoppeating

    cantstoppeating Member

    Joined:
    Nov 11, 2014
    Messages:
    584
    BDNF is known to act like a "fertilizer" for neurons:

    http://www.cbass.com/Miracle-GroBrain.htm

    Aerobic exercise has shown to increase levels of BDNF, fascilitating memory formation and general learning. There's a book detailing how kids and adults could benefit from light aerobic exercise around studying for better retention and recall of material. BDNF seems to be a positive form of stress and something we want to occur.

    [​IMG]
     
  6. Tarmander

    Tarmander Member

    Joined:
    Apr 30, 2015
    Messages:
    3,117
    Gender:
    Male
    I have found something similar in my own studies. I believe I read an article not long ago that said elevated blood sugar levels can cause brain levels of BDNF to fall, and may be responsible for depression.
     
  7. nullredvector

    nullredvector Member

    Joined:
    Oct 17, 2013
    Messages:
    195
    Gender:
    Male
    Occupation:
    UPS
    Location:
    USA
    Beta alanine always comes up as elevated in my blood tests. Protective mechanis? Just a little bit supplementally gives me a flush
     
  8. Lokzo

    Lokzo Member

    Joined:
    Mar 26, 2016
    Messages:
    1,347
    Gender:
    Male
    Occupation:
    Naturopath
    Location:
    Melbourne
  9. Lokzo

    Lokzo Member

    Joined:
    Mar 26, 2016
    Messages:
    1,347
    Gender:
    Male
    Occupation:
    Naturopath
    Location:
    Melbourne
  10. Hans

    Hans Member

    Joined:
    Aug 24, 2017
    Messages:
    1,995
    Gender:
    Male
  11. Lokzo

    Lokzo Member

    Joined:
    Mar 26, 2016
    Messages:
    1,347
    Gender:
    Male
    Occupation:
    Naturopath
    Location:
    Melbourne
    Thank you.

    I am really enjoying Beta alanine. My workouts have improved at least 25%. My endurance is scary good and its only been like 5 days.
     
  12. BigChad

    BigChad Member

    Joined:
    Jun 28, 2019
    Messages:
    747
    Gender:
    Male
    What dosage, frequency. Are you using creatine or other aminos
     
  13. Lokzo

    Lokzo Member

    Joined:
    Mar 26, 2016
    Messages:
    1,347
    Gender:
    Male
    Occupation:
    Naturopath
    Location:
    Melbourne
    I've been loading Beta alanine, about 2 grams a day, split into two doses. I like it pre workout and then post workout or at night. Doesn't really matter tbh, just make sure there's some carbs nearby.

    I am also using Taurine on and off.

    No creatine, as that fks my 5-HT1A issue.
     
  14. BigChad

    BigChad Member

    Joined:
    Jun 28, 2019
    Messages:
    747
    Gender:
    Male
    What do you mean loading beta alanine? That dosage is normal/small?
    Why do you need carbs nearby beta alanine, does it lower blood sugar. Didn't know that.

    Whats your ht1a issue could you describe
     
Loading...