- May 7, 2013
Consumption of analgesics before a marathon and the incidence of cardiovascular, gastrointestinal and renal problems: a cohort study.
This incidence increased significantly with increasing analgesic dose. Nine respondents reported
temporary hospital admittance: three for temporary kidney failure (post-ibuprofen ingestion), four with bleeds (postaspirin ingestion) and two cardiac infarctions (postaspirin ingestion). None of the control reported hospital admittance.
Overall, the ‘drug-related’ incidence (defined as the percentage of respondents reporting AEs
out of the total number of respondents taking a particular analgesic) was highest with aspirin, followed by ibuprofen, and lowest with diclofenac in both subgroups (high and low doses of analgesics, table 1). At high doses, 10% of diclofenac users, 52% of ibuprofen users and 87% of aspirin users experienced AEs (table 1). Aspirin was associated with relatively numerous GI or kidney bleeds, compared with the other analgesics (reported by 49% of the ‘high-dose’ aspirin users).