Mauritio
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- Feb 26, 2018
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In this study they injected endotoxin into the hand of healthy volunteers.
As it turned out, one dose of endotoxin lead to persistent constriction of the blood vessel that took up to 1 week to recover!
There's molecules like nitric oxide, serotonin , bradikinin ,arachidonic acid or CO2 that dilate the blood vessels in general .
So to test the dilation ability they injected bradikinin or arachidonic acid (both raise NO) shortly after endotoxin exposure.
Both failed to relaxed the endothelium and it took a week to fully recover that ability.
I don't know why the blood vessels endothelium takes such a long time to recover their ability to relax after endotoxin exposure.
But that might explain why some individuals in later stages of their life or in bad health (high endotoxin) don't even respond to viagra anymore: the constant endotoxin exposure makes them "immune" to nitric oxid's vasodilation and causes "endothelial stunning" as the authors called it.
Maybe the endotoxin lowers CO2 too much . So there's no proper relaxation possible anymore.
I originally stumbled upon this ,because i think there's a connection between endotoxin and varicose veins . But wouldn't varicose veins have too much dilation and therefore profit from endotoxins constriction ?
(Endothelial "stunning" following a brief exposure to endotoxin: a mechanism to link infection and infarction? - PubMed)
As it turned out, one dose of endotoxin lead to persistent constriction of the blood vessel that took up to 1 week to recover!
There's molecules like nitric oxide, serotonin , bradikinin ,arachidonic acid or CO2 that dilate the blood vessels in general .
So to test the dilation ability they injected bradikinin or arachidonic acid (both raise NO) shortly after endotoxin exposure.
Both failed to relaxed the endothelium and it took a week to fully recover that ability.
I don't know why the blood vessels endothelium takes such a long time to recover their ability to relax after endotoxin exposure.
But that might explain why some individuals in later stages of their life or in bad health (high endotoxin) don't even respond to viagra anymore: the constant endotoxin exposure makes them "immune" to nitric oxid's vasodilation and causes "endothelial stunning" as the authors called it.
Maybe the endotoxin lowers CO2 too much . So there's no proper relaxation possible anymore.
I originally stumbled upon this ,because i think there's a connection between endotoxin and varicose veins . But wouldn't varicose veins have too much dilation and therefore profit from endotoxins constriction ?
(Endothelial "stunning" following a brief exposure to endotoxin: a mechanism to link infection and infarction? - PubMed)
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