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A zinc deficiency increases the M2 macrophage phenotype (Th2) of the immune system, which is anti-inflammatory and inhibits nitric oxide synthesis, but it also increases polyamines and angiogenesis.
The M1 phenotype (Th1) creates nitric oxide to fight off infections and so on.
So basically M1 is fight and destroy and M2 is build. An imbalance in both leads to problems, as M1 dominance is seen with autoimmune diseases, infections, diabetes, etc., and M2 dominance is seen in cancer and tumor patients.
Modern diets and diseases: NO-zinc balance. Under Th1, zinc and nitrogen monoxide (NO) collectively protect against viruses, AIDS, autoimmunity, diab... - PubMed - NCBI
"Both Zn++ and Cu++ show a concentration-dependent inactivation of a protease essential for the proliferation of the AIDS virus HIV-1, while zinc can help prevent diabetes complications through its intracellular activation of the enzyme sorbitol dehydrogenase (SDH). A Zn++ deficiency can lead to a premature transition from efficient Th1-dependent cellular antiviral immune functions to Th2-dependent humoral immune functions."
"Disregulation of the Th1/Th2 balance is responsible for autoimmune disorders such as diabetes mellitus."
"Under Th2, levels of interleukin-4 (II-4), II-6, II-10, leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) are raised, while levels of II-2, Zn++, NO and other substances are lowered. This makes things easier for viruses like HIV-1 which multiply in Th2 cells but rarely, if ever, in Th1 cells."
"sufficiency of Zn++ and NO prevents a shift of the Th1/Th2 balance towards Th2 and thereby slows the proliferation of HIV, which it also does by inactivating the HIV protease"
"Zinc deficiency also promotes cancer. Under the influence of Th1 cells, zinc inhibits the growth of tumours by activating the endogenous tumour-suppressor endostatin, which inhibits angiogenesis."
It's not that zinc will make you M1 dominant, zinc will only prevent the proliferation of Th2 cells at the expense of Th1 cells. Zinc works synergistically with selenium (best form is selenomethionine thanks to Travis' research) to inhibit cancer growth.
The M1 phenotype (Th1) creates nitric oxide to fight off infections and so on.
So basically M1 is fight and destroy and M2 is build. An imbalance in both leads to problems, as M1 dominance is seen with autoimmune diseases, infections, diabetes, etc., and M2 dominance is seen in cancer and tumor patients.
Modern diets and diseases: NO-zinc balance. Under Th1, zinc and nitrogen monoxide (NO) collectively protect against viruses, AIDS, autoimmunity, diab... - PubMed - NCBI
"Both Zn++ and Cu++ show a concentration-dependent inactivation of a protease essential for the proliferation of the AIDS virus HIV-1, while zinc can help prevent diabetes complications through its intracellular activation of the enzyme sorbitol dehydrogenase (SDH). A Zn++ deficiency can lead to a premature transition from efficient Th1-dependent cellular antiviral immune functions to Th2-dependent humoral immune functions."
"Disregulation of the Th1/Th2 balance is responsible for autoimmune disorders such as diabetes mellitus."
"Under Th2, levels of interleukin-4 (II-4), II-6, II-10, leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) are raised, while levels of II-2, Zn++, NO and other substances are lowered. This makes things easier for viruses like HIV-1 which multiply in Th2 cells but rarely, if ever, in Th1 cells."
"sufficiency of Zn++ and NO prevents a shift of the Th1/Th2 balance towards Th2 and thereby slows the proliferation of HIV, which it also does by inactivating the HIV protease"
"Zinc deficiency also promotes cancer. Under the influence of Th1 cells, zinc inhibits the growth of tumours by activating the endogenous tumour-suppressor endostatin, which inhibits angiogenesis."
It's not that zinc will make you M1 dominant, zinc will only prevent the proliferation of Th2 cells at the expense of Th1 cells. Zinc works synergistically with selenium (best form is selenomethionine thanks to Travis' research) to inhibit cancer growth.