yerrag

Member
Joined
Mar 29, 2016
Messages
10,883
Location
Manila
Fish collagen should be safely free of glysophates.
It would depend on what fish it is where it's extracted from. What if it's farm-raised tilapia?
 

Soren

Member
Forum Supporter
Joined
Apr 5, 2016
Messages
1,648
Looks like serine is more problematic, and whether glycine can be an issue depends on methyl donor availability

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine and glycine can be interconverted and either might be used for nucleotide synthesis and one-carbon metabolism, we show that exogenous glycine cannot replace serine to support cancer cell proliferation. Cancer cells selectively consumed exogenous serine, which was converted to intracellular glycine and one-carbon units for building nucleotides. Restriction of exogenous glycine or depletion of the glycine cleavage system did not impede proliferation. In the absence of serine, uptake of exogenous glycine was unable to support nucleotide synthesis. Indeed, higher concentrations of glycine inhibited proliferation. Under these conditions, glycine was converted to serine, a reaction that would deplete the one-carbon pool. Providing one-carbon units by adding formate rescued nucleotide synthesis and growth of glycine-fed cells. We conclude that nucleotide synthesis and cancer cell proliferation are supported by serine—rather than glycine—consumption.

Based on this do you think it is safer for one to take just pure glycine instead of collagen as collagen contains Serine?
 

yerrag

Member
Joined
Mar 29, 2016
Messages
10,883
Location
Manila
What I don't understand about this is that glycine along with cysteine is used to make glutathione. As discussed here Blocking Cystine, And Thus Glutathione (GSH) Synthesis, Kills Cancer Stem Cells cancer cells use glutathione to protect themselves.
Isn't glycine going to push the body towards a more reduced state? If this is the case how is it protective against cancer?
If you think the only thing glycine is used for is to make glutathione (and it isn't), and that the only use for glutathione is to protect cancer cells, then stopping glycine intake is like a doctor telling people to stop eating high purine foods just because it will increase uric acid production, as if uric acid is what's causing gout (overlooking the fact that uric acid is a protective anti-oxidant that is increased when the body needs it, and that the gout is caused by high ecf acidity, which causes uric acid to precipitate and cause joint pain and inflammation).

I'm not a fan of studies that make conclusions that are sweeping where the context is narrow and does not describe all contexts. How the body decides to use its resources to protect itself, when to produce ROS to kill a foreign entity, and when not to, and when to produce anti-oxidants to counter oxidative stresses, is best left to the body, and our job is to ensure our body is in a state of balance, or homeostasis. This can be done by providing the body with the nutrition, including clean air and sunshine, and by limiting exposure to toxins and pathogens. Being in a good mental state also helps.

Most, or all, studies are done in isolation and do not represent the real world, try as hard as these studies do. Their conclusions are helpful only if we understand well how the body works. The body, when healthy, can shift from be running on oxidative mode, where oxidative stress can occur, but it has anti-oxidants ready to stop the oxidative stresses that can damage tissues.

Selenium (and glycine as well) for example, is needed to produce glutathione to make glutathione peroxide to keep the body from producing too much hydrogen peroxide that is needed to produce thyroid. If selenium is deficient, this could lead to tissue damage in the thyroid gland. In this example, glutathione is needed. And glycine is needed.

So, restricting glycine because a study says it is bad (for a very narrow context) could lead to another pathology.

Even if that context applies, where glutathione can be used by cancer cells to protect itself, would restricting glycine be helpful if it causes the body to be weaker, and if that happens, would it be strong enough to produce the natural killer cells to destroy the cancer?
 

Similar threads

Back
Top Bottom