Erythrose, A Sugar Similar To Glucose, Which Makes Cancer Cells Respire And Therefore Die, Studies

[TreasureVibe]

Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma
Abstract 4548: Erythrose kill cancer cell in vitro and inhibit tumor growth in vivo
Beat Cancer Save Life: Money - Develop Erythrose to Treat Cancer
Cancer Die with Erythrose - Erythrose Defeat Cancer

Summary of Erythrose Beat Cancer Erythrose (C4H8O4) is a sugar, 2/3 of glucose (C6H12O6). Not only erythrose has similar structure as glucose, but also it can be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960). Erythrose-4-phosphate is in our body. (participates in Pentose Phosphate Pathway) Low toxicity: Erythrose’s mirror, erythrulose, toxicity is very low (NICNAS, Australia 2008). Cancer cell lines (lung, brain, breast, etc) die with ~4mM erythrose in 24hrs. Blood glucose reaches ~8 mM after meal, people with diabetes can tolerate 30mM for days. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested. Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible Although erythrose is a sugar and existed in our body. Before proper testing, it should not be used for any one. It could be very dangerous without proper administration. The solution is very simple to understand. High school education is enough to understand. You just need common sense and logical think to understand that this is the only way we can beat cancer and save life. In general, it costs $1 billion to develop a drug. I have tried to raise fund. I have not got. I do not give up. But I can not deliver what I want without money. Life is priceless for everyone. Unfortunately, there is price tag I cannot afford. What is Cancer? According to National Cancer Institutes: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cell’s Life: cells >> divide >> differentiate to functional cell >> die. Cancer cells are our cells of our body. Cancer is a disease of undifferentiated dividing cells. Make cancer cell differentiate. Cancer is stopped!!! How Cell Survive? (Cellular Respiration)

All cells of our body need energy to survive. There are two major energy processes, respiration and fermentation. Most cells in our body have the abilities of both fermentation and respiration. Glucose is major universal fuel of our body. In respiration, with oxygen participation, the cell converts glucose to carbon dioxide and water.In fermentation, without oxygen participation, the cell converts glucose to lactate. What is the difference between differentiated cell and cancer?(Heiden, et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029 (2009))

Since 1920’s, eighty years ago, people have known that normal cells mainly depend on respiration, while cancer cells mainly depend on fermentation. Not all cells mainly depending on fermentation divide. But all cells mainly depending on respiration do not divide. There are many and various reasons of cancer, genes, pathways, etc. The most profound, obvious, and significant difference is that differentiated cells (normal cells) mainly depend on respiration; while cancer cells mainly depend on fermentation. Dr. Warburg first reported this in 1920's. Not all cells, mainly powered by fermentation, divide. All cells, mainly powered by respiration, do not divide. Increasing cancer cell respiration will stop cancer cell dividing. How to increase cell respiration? Increasing mitochondria respiration. In human cell, respiration is in mitochondria. Mitochondria respiration is suppressed in cancer and other dividing cells. Cell division could be the reason of mitochondria suppression. Increasing non-mitochondria respiration. Aerobic bacteria without mitochondria have non-mitochondria respiration ability. Cancer cell has high oxidative stress, which has advantage to use non-mitochondrial respiration. Giving proper substance to cancer cell will destroy cancer. What does cancer like? Because cancer mainly depends on fermentation, cancer cells take more sugar than normal cell. Cancer likes sugar. PET Scan is based on this. What will happen if we give cancer a sugar, cancer has to use it for respiration? The sugar is erythrose. What is Erythrose?

Erythrose is a sugar, has 2/3 weight of glucose and similar structure. Erythrose is used for respiration. Feed rat radioactive erythrose, the radioactivity appears in respiratory carbon dioxide, in glucose or liver glycogen, and in urinary excretion (Batt et al. 1960). The final products are carbon dioxide and water. Erythrose-4-phosphate is in our body, participates in Pentose Phosphate Pathway In human health effects assessment with erythrulose, an isomer of erythrose, in rat, acute oral LD50 >2 g/kg bw, low toxicity; rat, repeat dose oral toxicity – 28 days, No Observed Effect Level (NOEL) is 1g/kg bw/day. It is non mutagenic to bacterial reverse mutation (NICNAS Australia, 2008). Cell Culture with Erythrose Cancer cell lines (lung, brain, breast, etc.) die with ~4mM (500mg/L) erythrose in 24 hrs. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.

Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible. Cancer cells die with enough erythrose, the concentration is well below similar small molecules our body can tolerate. Using Erythrose treat cancer is doable, and will be workable.

Basic Biology of Cancer: Erythrose vs. Cancer


Abstract
In general, mutations in oncogenes and tumor suppressor genes are believed to represent the fundamental cause of carcinogenesis. Mitochondrial deficiency (Warburg effect) may be a direct or indirect consequence of these mutations. Accordingly, tumor cells depend on glycolysis rather than mitochondrial oxidative metabolism as energy source for their survival and proliferation. Targeting this kind of metabolism could offer a possibility for cancer treatment. Erythrose was used as an alternative energy source to test its inhibitory effect on several tumor cell lines in vitro and in vivo.

Cancer cell lines (breast BT474 and MCF-7, brain U87mg, pancreas Panc-1, HEL, LL-2 Lewis lung, and colorectal CT26 and SW480 lines) were grown in DMEM + 10% FBS media with different concentrations of D-erythrose and cell growth was tested with the Trypan blue assay. In general, 70% of cancer cells did not survive after 24 hrs of culture with 500mg/L D-erythrose. Addition of ZnCl2 (40µM) doubled the cancer killing effect at 400mg/L D-erythrose. In addition, LL-2 Lewis lung cells were subcutaneously introduced into the immunocompetent C57BL/6 mice. After allowing tumor growth to 2.7±0.4mm wide diameters, a daily subcutaneous injection beside the tumor with D-erythrose (∼1g/kg bw) was administered for 25 days; controls received a PBS injection instead. Tumor growth in erythrose-treated mice was inhibited more than 90% by weight.

We hypothesize that the administration of erythrose leads to CO2 production from oxidation in cytosol or mitochondria. Carbonic acid is formed from CO2 and water, accelerated by carbonic anhydrase (a zinc enzyme), which can convert lactate to lactic acid, and cause intracellular acidosis and cancer death since cancer cells have increased lactate production.
Abstract 4548: Erythrose kill cancer cell in vitro and inhibit tumor growth in vivo

I stumbled upon this substance by chance in this video:



Uploader's channel with explanatory videos: endingcancer

It was first extracted from rhubarb, source: Erythrose - Wikipedia
Ray Peat wrote about the anti cancer benefits of rhubarb and health benefits in general in these 2 articles because it contains anthraquinones: Heart and hormones
Cascara, energy, cancer and the FDA's laxative abuse.

2015 article on rhubarb showing other anti-cancer constituents: RHUBARB can save your life: Ingredient in plant kills half of cancer cells in 48 hours

The idea is simple, cancer cells crave glucose. They will therefore take erythrose, a natural compound nearly similar to glucose. This will cause conversion of lactate to lactic acid, causing intracellular acidosis, killing the cancer cell. Cancer cells without mitochondria or functional mitochondria can respire through the cytosol. From one of the explanatory videos:

How to increase respiration?
- In human cells, respiration mainly occurs in mitochondria. Mitochondria are dysfunctional or defect in all cancer cells. Mitochondria are controlled by the genetic code from both the mitochondria and the nucleus. Increasing respiration in the mitochondria will be harder than diamond.
- Many aerobic bacteria have no mitochondria, but have respiration - Cytosolic Respiration.
Human cells also have Cytosolic Respiration.
- Increasing Cytosolic Respiration will initiate cell differentiation of dividing cell.

The best way to increase Respiration
- What does cancer like? Because cancer mainly depends on fermentation, the cancer cell takes more sugar than the normal cell. Cancer likes sugar. PET scan is based on this. What will happen if we give cancer a sugar, that cancer has to use for respiration? In the Cytosol likely.
- The sugar is Tetrose. Among tetrose, erythrose is the strongest anti-cancer agent.
- Erythrose initializes cell differentiation, and causes cancer cell death.

Erythrose
- Erythrose (C4H8O4) is a monosaccharide - a sugar.
* 2/3 of weight of glucose (C6H12O6 the universal fuel of our body)
*Erythrose has a very similar structure (line or circle) as glucose.
- Not only does Erythrose have a similar structure to glucose, but it can also be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960).
- Erythrose-4-phosphate is in our body. (participates in the Pentose Phosphate Pathway)
- Erythrose's mirror, erythrulose, has very low toxicity (NICNAS, Australia 2008).

Erythrose, Our body & Cell Differentiation
- Erythrose-4-phosphate is in our body. In cell culture viability study, up to 30 mM erythrose, it has (sic) very similar to glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have similar cell division and ratio of living cells and dead cells as with glucose. It indicates that erythrose will have no or (sic) side effect as high sugar (diabetic).
- The cells cultured with erythrose have morphology change, which indicates that erythrose initializes cell differentiation.

Erythrose vs. Cancer
- Cancer cell lines die in vitro
* ~4mM (500mg/L) kill ~70% in 24 hours in 1g/L glucose DMEM media
* ~3mM (400mg/L) + 10 µM zinc kills ~80% + 40 µm zinc kills >90% MCF-7
- Works for all different cell lines tested
* LL2 (mouse lung cancer), MCF-7 (human breast cancer), SW480 (human colorectal cancer), CT26 (mouse colon cancer), U89mg (human brain cancer), Panc-1 (human pancreas cancer), HEL (Human Erythroleukemia), etc.
- Inhibits/shrinks tumour in vivo
~1g/kg bw/day subcutanously inhibits >90% tumor (LL2) growth in 25 days I can get better results than this.
- Experiments were done in 3 independent labs
- There are many types of cells in our body. How human body reacts to erythrose needs further study, especially, to high concentration, with which cancer die.

Source

Opinions?









@haidut

 

[haidut]

Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma
Abstract 4548: Erythrose kill cancer cell in vitro and inhibit tumor growth in vivo
Beat Cancer Save Life: Money - Develop Erythrose to Treat Cancer
Cancer Die with Erythrose - Erythrose Defeat Cancer

Summary of Erythrose Beat Cancer Erythrose (C4H8O4) is a sugar, 2/3 of glucose (C6H12O6). Not only erythrose has similar structure as glucose, but also it can be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960). Erythrose-4-phosphate is in our body. (participates in Pentose Phosphate Pathway) Low toxicity: Erythrose’s mirror, erythrulose, toxicity is very low (NICNAS, Australia 2008). Cancer cell lines (lung, brain, breast, etc) die with ~4mM erythrose in 24hrs. Blood glucose reaches ~8 mM after meal, people with diabetes can tolerate 30mM for days. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested. Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible Although erythrose is a sugar and existed in our body. Before proper testing, it should not be used for any one. It could be very dangerous without proper administration. The solution is very simple to understand. High school education is enough to understand. You just need common sense and logical think to understand that this is the only way we can beat cancer and save life. In general, it costs $1 billion to develop a drug. I have tried to raise fund. I have not got. I do not give up. But I can not deliver what I want without money. Life is priceless for everyone. Unfortunately, there is price tag I cannot afford. What is Cancer? According to National Cancer Institutes: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cell’s Life: cells >> divide >> differentiate to functional cell >> die. Cancer cells are our cells of our body. Cancer is a disease of undifferentiated dividing cells. Make cancer cell differentiate. Cancer is stopped!!! How Cell Survive? (Cellular Respiration)

All cells of our body need energy to survive. There are two major energy processes, respiration and fermentation. Most cells in our body have the abilities of both fermentation and respiration. Glucose is major universal fuel of our body. In respiration, with oxygen participation, the cell converts glucose to carbon dioxide and water.In fermentation, without oxygen participation, the cell converts glucose to lactate. What is the difference between differentiated cell and cancer?(Heiden, et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science 324, 1029 (2009))

Since 1920’s, eighty years ago, people have known that normal cells mainly depend on respiration, while cancer cells mainly depend on fermentation. Not all cells mainly depending on fermentation divide. But all cells mainly depending on respiration do not divide. There are many and various reasons of cancer, genes, pathways, etc. The most profound, obvious, and significant difference is that differentiated cells (normal cells) mainly depend on respiration; while cancer cells mainly depend on fermentation. Dr. Warburg first reported this in 1920's. Not all cells, mainly powered by fermentation, divide. All cells, mainly powered by respiration, do not divide. Increasing cancer cell respiration will stop cancer cell dividing. How to increase cell respiration? Increasing mitochondria respiration. In human cell, respiration is in mitochondria. Mitochondria respiration is suppressed in cancer and other dividing cells. Cell division could be the reason of mitochondria suppression. Increasing non-mitochondria respiration. Aerobic bacteria without mitochondria have non-mitochondria respiration ability. Cancer cell has high oxidative stress, which has advantage to use non-mitochondrial respiration. Giving proper substance to cancer cell will destroy cancer. What does cancer like? Because cancer mainly depends on fermentation, cancer cells take more sugar than normal cell. Cancer likes sugar. PET Scan is based on this. What will happen if we give cancer a sugar, cancer has to use it for respiration? The sugar is erythrose. What is Erythrose?

Erythrose is a sugar, has 2/3 weight of glucose and similar structure. Erythrose is used for respiration. Feed rat radioactive erythrose, the radioactivity appears in respiratory carbon dioxide, in glucose or liver glycogen, and in urinary excretion (Batt et al. 1960). The final products are carbon dioxide and water. Erythrose-4-phosphate is in our body, participates in Pentose Phosphate Pathway In human health effects assessment with erythrulose, an isomer of erythrose, in rat, acute oral LD50 >2 g/kg bw, low toxicity; rat, repeat dose oral toxicity – 28 days, No Observed Effect Level (NOEL) is 1g/kg bw/day. It is non mutagenic to bacterial reverse mutation (NICNAS Australia, 2008). Cell Culture with Erythrose Cancer cell lines (lung, brain, breast, etc.) die with ~4mM (500mg/L) erythrose in 24 hrs. For normal cell lines viability, up to 30mM erythrose, it has similar result as glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have been tested.

Erythrose is very similar to glucose for our cells, but kills cancer. Energy is essential for all cells in our body. Technology can deliver the 4mM erythrose to anywhere in our body. Cancer will be destroyed. The side effects could be as short-term diabetes, manageable and reversible. Cancer cells die with enough erythrose, the concentration is well below similar small molecules our body can tolerate. Using Erythrose treat cancer is doable, and will be workable.

Basic Biology of Cancer: Erythrose vs. Cancer


Abstract
In general, mutations in oncogenes and tumor suppressor genes are believed to represent the fundamental cause of carcinogenesis. Mitochondrial deficiency (Warburg effect) may be a direct or indirect consequence of these mutations. Accordingly, tumor cells depend on glycolysis rather than mitochondrial oxidative metabolism as energy source for their survival and proliferation. Targeting this kind of metabolism could offer a possibility for cancer treatment. Erythrose was used as an alternative energy source to test its inhibitory effect on several tumor cell lines in vitro and in vivo.

Cancer cell lines (breast BT474 and MCF-7, brain U87mg, pancreas Panc-1, HEL, LL-2 Lewis lung, and colorectal CT26 and SW480 lines) were grown in DMEM + 10% FBS media with different concentrations of D-erythrose and cell growth was tested with the Trypan blue assay. In general, 70% of cancer cells did not survive after 24 hrs of culture with 500mg/L D-erythrose. Addition of ZnCl2 (40µM) doubled the cancer killing effect at 400mg/L D-erythrose. In addition, LL-2 Lewis lung cells were subcutaneously introduced into the immunocompetent C57BL/6 mice. After allowing tumor growth to 2.7±0.4mm wide diameters, a daily subcutaneous injection beside the tumor with D-erythrose (∼1g/kg bw) was administered for 25 days; controls received a PBS injection instead. Tumor growth in erythrose-treated mice was inhibited more than 90% by weight.

We hypothesize that the administration of erythrose leads to CO2 production from oxidation in cytosol or mitochondria. Carbonic acid is formed from CO2 and water, accelerated by carbonic anhydrase (a zinc enzyme), which can convert lactate to lactic acid, and cause intracellular acidosis and cancer death since cancer cells have increased lactate production.
Abstract 4548: Erythrose kill cancer cell in vitro and inhibit tumor growth in vivo

I stumbled upon this substance by chance in this video:



Uploader's channel with explanatory videos: endingcancer

It was first extracted from rhubarb, source: Erythrose - Wikipedia
Ray Peat wrote about the anti cancer benefits of rhubarb and health benefits in general in these 2 articles because it contains anthraquinones: Heart and hormones
Cascara, energy, cancer and the FDA's laxative abuse.

2015 article on rhubarb showing other anti-cancer constituents: RHUBARB can save your life: Ingredient in plant kills half of cancer cells in 48 hours

The idea is simple, cancer cells crave glucose. They will therefore take erythrose, a natural compound nearly similar to glucose. This will cause conversion of lactate to lactic acid, causing intracellular acidosis, killing the cancer cell. Cancer cells without mitochondria or functional mitochondria can respire through the cytosol. From one of the explanatory videos:

How to increase respiration?
- In human cells, respiration mainly occurs in mitochondria. Mitochondria are dysfunctional or defect in all cancer cells. Mitochondria are controlled by the genetic code from both the mitochondria and the nucleus. Increasing respiration in the mitochondria will be harder than diamond.
- Many aerobic bacteria have no mitochondria, but have respiration - Cytosolic Respiration.
Human cells also have Cytosolic Respiration.
- Increasing Cytosolic Respiration will initiate cell differentiation of dividing cell.

The best way to increase Respiration
- What does cancer like? Because cancer mainly depends on fermentation, the cancer cell takes more sugar than the normal cell. Cancer likes sugar. PET scan is based on this. What will happen if we give cancer a sugar, that cancer has to use for respiration? In the Cytosol likely.
- The sugar is Tetrose. Among tetrose, erythrose is the strongest anti-cancer agent.
- Erythrose initializes cell differentiation, and causes cancer cell death.

Erythrose
- Erythrose (C4H8O4) is a monosaccharide - a sugar.
* 2/3 of weight of glucose (C6H12O6 the universal fuel of our body)
*Erythrose has a very similar structure (line or circle) as glucose.
- Not only does Erythrose have a similar structure to glucose, but it can also be used for respiration as glucose, to be converted to CO2 and H2O (Batt et al. 1960).
- Erythrose-4-phosphate is in our body. (participates in the Pentose Phosphate Pathway)
- Erythrose's mirror, erythrulose, has very low toxicity (NICNAS, Australia 2008).

Erythrose, Our body & Cell Differentiation
- Erythrose-4-phosphate is in our body. In cell culture viability study, up to 30 mM erythrose, it has (sic) very similar to glucose. Human umbilical vein endothelial cell (HUVEC) and Human Dermal Fibroblasts (HDF) have similar cell division and ratio of living cells and dead cells as with glucose. It indicates that erythrose will have no or (sic) side effect as high sugar (diabetic).
- The cells cultured with erythrose have morphology change, which indicates that erythrose initializes cell differentiation.

Erythrose vs. Cancer
- Cancer cell lines die in vitro
* ~4mM (500mg/L) kill ~70% in 24 hours in 1g/L glucose DMEM media
* ~3mM (400mg/L) + 10 µM zinc kills ~80% + 40 µm zinc kills >90% MCF-7
- Works for all different cell lines tested
* LL2 (mouse lung cancer), MCF-7 (human breast cancer), SW480 (human colorectal cancer), CT26 (mouse colon cancer), U89mg (human brain cancer), Panc-1 (human pancreas cancer), HEL (Human Erythroleukemia), etc.
- Inhibits/shrinks tumour in vivo
~1g/kg bw/day subcutanously inhibits >90% tumor (LL2) growth in 25 days I can get better results than this.
- Experiments were done in 3 independent labs
- There are many types of cells in our body. How human body reacts to erythrose needs further study, especially, to high concentration, with which cancer die.

Source

Opinions?









@haidut

Regular sucrose and trehalose are non-reducing sugars and as such are good as food for both healthy people and ones with cancer. Cancer cells actually prefer fat as fuel and "waste" glucose by converting a lot of it into lactic acid and whatever gets through the Krebs cycle goes into the fatty acid synthase (FAS) cycle. Then the cancer cells oxidize that fat. Inhibitors of FAS or LDH (enzyme generating lactate) are promising targets for cancer treatment, as are inhibitors of PDK (enzyme that blocks PDH). We have discussed this before on the forum. There is probably no need for more exotic sugars in the diet but if these do not feed into the lactic acid and FAS cycle then they would be good to try.
Yet Another Study Calls For Inhibiting Fat Oxidation As A Treatment For Cancer
Inhibiting Lipolysis May Treat / Cure Cancer
Cancer Is A State Of Chronic Stress With Elevated Lipolysis And Ketogenesis
Thiamine Acts Similarly To DCA And May Be Helpful In Cancer

 

[TreasureVibe]

Regular sucrose and trehalose are non-reducing sugars and as such are good as food for both healthy people and ones with cancer. Cancer cells actually prefer fat as fuel and "waste" glucose by converting a lot of it into lactic acid and whatever gets through the Krebs cycle goes into the fatty acid synthase (FAS) cycle. Then the cancer cells oxidize that fat. Inhibitors of FAS or LDH (enzyme generating lactate) are promising targets for cancer treatment, as are inhibitors of PDK (enzyme that blocks PDH). We have discussed this before on the forum. There is probably no need for more exotic sugars in the diet but if these do not feed into the lactic acid and FAS cycle then they would be good to try.
Yet Another Study Calls For Inhibiting Fat Oxidation As A Treatment For Cancer
Inhibiting Lipolysis May Treat / Cure Cancer
Cancer Is A State Of Chronic Stress With Elevated Lipolysis And Ketogenesis
Thiamine Acts Similarly To DCA And May Be Helpful In Cancer

Thanks Haidut. Could you please comment on Naessen's conclusion that cancer cells are deficient in nitrogen and that sating them with nitrogen made them dissolve? And that tumors have a "nitrogen trap"? And what do you know of the role of nitrogen in general in metabolism and cancer? You once spoke about nitrous oxide being helpful in depression so you should be open to it.
From Naessens his works:
N.B. : Clinical observations using a lymphograph revealed that the lymph of a person afflicted with a degenerative disease is both thick and stagnant. It does not flow freely. This observation raised the hypothesis that the lack of fluidity in the lymph can be a biological precursor to degenerative diseases.

2. It brings nitrogen to the organism as an active ingredient. Nitrogen is a fundamental element to the creation of living matter : it is also an essential element to cellular repair. It is carried to the blood stream by the lymphatic circulation.

Where cancer is present (uncontrolled immature cell division) immature cells reach a critical mass that requires nitrogen to develop. These cells then secrete a substance which paralyses the immune system so that they can then get their required nitrogen from healthy cells.

A vicious cycle then is established which supports the growth of cancerous cells while the immune system is unable to act.

By bringing nitrogen to the immature cells, 714X stops the secretion of the paralyzing factor by the immature cells thus allowing the immune system to recover its natural functions.

Thnx.

 

[haidut]

Thanks Haidut. Could you please comment on Naessen's conclusion that cancer cells are deficient in nitrogen and that sating them with nitrogen made them dissolve? And that tumors have a "nitrogen trap"? And what do you know of the role of nitrogen in general in metabolism and cancer? You once spoke about nitrous oxide being helpful in depression so you should be open to it.
From Naessens his works:
N.B. : Clinical observations using a lymphograph revealed that the lymph of a person afflicted with a degenerative disease is both thick and stagnant. It does not flow freely. This observation raised the hypothesis that the lack of fluidity in the lymph can be a biological precursor to degenerative diseases.

2. It brings nitrogen to the organism as an active ingredient. Nitrogen is a fundamental element to the creation of living matter : it is also an essential element to cellular repair. It is carried to the blood stream by the lymphatic circulation.

Where cancer is present (uncontrolled immature cell division) immature cells reach a critical mass that requires nitrogen to develop. These cells then secrete a substance which paralyses the immune system so that they can then get their required nitrogen from healthy cells.

A vicious cycle then is established which supports the growth of cancerous cells while the immune system is unable to act.

By bringing nitrogen to the immature cells, 714X stops the secretion of the paralyzing factor by the immature cells thus allowing the immune system to recover its natural functions.

Thnx.

I think cancer cells are "nitrogen traps" simply due to their high proliferation and growth rates. Since I do not believe that there such an entity as "cancer" cell which is somehow fundamentally different from a regular cell, I don't think the approach should be to bring more nitrogen to the cell but rather simply restoring the optimal environment for cell function. That means reduction of the stress mediators, increasing supply of glucose, decreasing supply of fat and opposing learned helplessness would be the main things I'd try. Improving steroid balance with higher doses pregnenolone/progesterone, adding some DHEA/T/DHT can serve as a strong signal that "things are OK" so that the cell quorum reverses its decision to grow. If you look at some of the studies on limiting lipolysis you will see that in some studies simply providing a hefty dose of niacinamide to reduce lipolysis made the tumors disappear completely. Even terminal stage cancers in the liver and possibly pancreas. My guess is that addressing excessive lipolysis, lactate, hormonal imbalance, and serotonin can probably shut down any tumor and possibly resolve it completely over time.

 

[TreasureVibe]

I think cancer cells are "nitrogen traps" simply due to their high proliferation and growth rates. Since I do not believe that there such an entity as "cancer" cell which is somehow fundamentally different from a regular cell, I don't think the approach should be to bring more nitrogen to the cell but rather simply restoring the optimal environment for cell function. That means reduction of the stress mediators, increasing supply of glucose, decreasing supply of fat and opposing learned helplessness would be the main things I'd try. Improving steroid balance with higher doses pregnenolone/progesterone, adding some DHEA/T/DHT can serve as a strong signal that "things are OK" so that the cell quorum reverses its decision to grow. If you look at some of the studies on limiting lipolysis you will see that in some studies simply providing a hefty dose of niacinamide to reduce lipolysis made the tumors disappear completely. Even terminal stage cancers in the liver and possibly pancreas. My guess is that addressing excessive lipolysis, lactate, hormonal imbalance, and serotonin can probably shut down any tumor and possibly resolve it completely over time.

Hmm, but Naessens spoke of regular immature cells, (note: regular, so they were not fundamentally different from regular cells just like you mentioned), that would form a ''critical mass" (the beginning stage of a tumor, a lump or lesion or a pre-stage of that, presumably, with critical he means the point of where the process of actual tumor formation i.e. cancer cells ''oneness'' starts), and then from that point on starts to try to become a new entity on its own, a ''tumor'', which the cancerous cells require excess nitrogen to do so, (more than normal cells require, which normally require nitrogen too), and in order to get that excess nitrogen, they start collectively secreting a substance that paralyzes the immune system and gives them the ability to steal nitrogen from healthy cells. You could say this is the first point of where cancer cells operate collectively as "one", if you don't count the cumulation of the immature cells.

I mean, it's not really different from your rendition, it fits in perfectly, only Naessens had the tools to see things we can't see, like the cancerogenic K factor (CKF or CLF). Naessens magnified an early/the beginning stage of a tumor, on such a tiny scale, which is why it is still yet unknown to mainstream research. Naessens rendition doesn't disagree with your rendition, he only analyzed the beginning stage of a tumor on a scale that is not used in mainstream science yet. Naessens argued for actual malignancy.

What you are arguing is that a tumor is not an entity of its own physiologically, but rather a collection of dysfunctional cells. Naessens argued that the collection of multiple immature cells really "becomes one" i.e. a tumor, an actual entity of its own, and seeks to do that. And it does this through the use of excess nitrogen.

Why not make use of that knowledge and try to seek to incorporate it into the current idea of treating cancer here, through dietary and perhaps supplemental means? All that Naessens gave to treat his cancer patients was nitrogenated camphor.

Why not be open minded to both ''dysfunctional cancer'' (Ray Peat style) and ''malignant cancer'' (Naessens style)? This could explain all the confusion about wether cancer feeds with fat or with sugar too. Perhaps it depends on wether it is a dysfunctional mass, or a malignant mass.

With malignancy I think the best way to describe it, is the formation of an entity which functions on its own, presumably only with 2 functions i.e. feeding and growing, but nevertheless independent from the host. Metabolic correction will not make it go away (with the current knowledge on metabolic correction Ray Peat style).

Where as with dysfunctional cancer, you could argue that it feeds and grows uncontrollably, but is more easily resolved through metabolic correction and has less the characteristic of ''a will of its own'' through laymen's eyes, in order words it is less able to be influenced by the current means like the RP metabolic supplements and drugs, more resistant.

Soft and hard cancer. Soft cancer dissolves easily through metabolic RP means, while hard cancer does not. Both have the ability to divide uncontrollably and even set foot in other tissue, where as a benign tumor does not, which defines the distinction between them and a benign tumor.

You might even say, nitrogen-poor cancer/tumor and nitrogen-rich cancer/tumor.

Look at how a plant with nitrogen toxicity looks like:
https://www.growweedeasy.com/wp-content/uploads/2010/10/nitrogen-toxicity-cannabis.jpg

This crusty hardness.

Now look at a nitrogen deficient plant:

https://www.growweedeasy.com/wp-content/uploads/2010/10/nitrogen-deficiency-wilted-leaf.jpg

Thin, yellow, weakish.

The source of the second picture even states

"If new leaves aren't getting enough nitrogen, the plant will start to "steal" nitrogen from the older, lower leaves, so that it can give it to newer leaves. This is what causes the yellowing and wilting of a nitrogen deficiency."

Source

How can you not see the analogue with cancer? Are you really sure there is no role for nitrogen in the pathology as Naessens described?

Cancer tumors have a distinctive nitrogen trap, this has been well described in literature throughout the ages.

Perhaps ''cancer always comes back'' because this secretion of CKF is not dealt with through enough nitrogen to the cancer cells, so the immune system is always paralyzed to an extent of clearing cancer completely.

I'm saying, why not both?

 

[haidut]

Hmm, but Naessens spoke of regular immature cells, (note: regular, so they were not fundamentally different from regular cells just like you mentioned), that would form a ''critical mass" (the beginning stage of a tumor, a lump or lesion or a pre-stage of that, presumably, with critical he means the point of where the process of actual tumor formation i.e. cancer cells ''oneness'' starts), and then from that point on starts to try to become a new entity on its own, a ''tumor'', which the cancerous cells require excess nitrogen to do so, (more than normal cells require, which normally require nitrogen too), and in order to get that excess nitrogen, they start collectively secreting a substance that paralyzes the immune system and gives them the ability to steal nitrogen from healthy cells. You could say this is the first point of where cancer cells operate collectively as "one", if you don't count the cumulation of the immature cells.

I mean, it's not really different from your rendition, it fits in perfectly, only Naessens had the tools to see things we can't see, like the cancerogenic K factor (CKF or CLF). Naessens magnified an early/the beginning stage of a tumor, on such a tiny scale, which is why it is still yet unknown to mainstream research. Naessens rendition doesn't disagree with your rendition, he only analyzed the beginning stage of a tumor on a scale that is not yet used in mainstream science yet. Naessens argued for actual malignancy.

What you are arguing is that a tumor is not an entity of its own physiologically, but rather a collection of dysfunctional cells. Naessens argued that the collection of multiple immature cells really "becomes one" i.e. a tumor, an actual entity of its own, and seeks to do that. And it does this through the use of excess nitrogen.

Why not make use of that knowledge and try to seek to incorporate it into the current idea of treating cancer here, through dietary and perhaps supplemental means? All that Naessens gave to treat his cancer patients was nitrogenated camphor.

Why not be open minded to both ''dysfunctional cancer'' (Ray Peat style) and ''malignant cancer'' (Naessens style)? This could explain all the confusion about wether cancer feeds with fat or with sugar too. Perhaps it depends on wether it is a dysfunctional mass, or a malignant mass.

With malignancy I think the best way to describe it, is the formation of an entity which functions on its own, presumably only with 2 functions i.e. feeding and growing, but nevertheless independent from the host. Metabolic correction will not make it go away (with the current knowledge on metabolic correction Ray Peat style).

Where as with dysfunctional cancer, you could argue that it feeds and grows uncontrollably, but is more easily resolved through metabolic correction and has less the characteristic of ''a will of its own''.

Soft and hard cancer. Soft cancer dissolves easily through metabolic RP means, while hard cancer does not. Both have the ability to divide uncontrollably and even set foot in other tissue, where as a benign tumor does not, which defines the distinction between them and a benign tumor.

Peat spoke about cancer being a sort of "ad-hoc" organ - regular cells acting weirdly due to poor environmental conditions. If you search for his article where he explains that I think his explanation would be thousand times better than I can offer. One of the most illustrating examples he gives is the one of a salamander who never develops cancer no matter how many tumor grafts are transplanted on it. So, something in the salamander makes those well-developed tumors consisting of fully "cancerous" cells to completely differentiate and turn into normal salamander tissue. The salamander does not dissolve or destroys the transplanted tumors, it does not kill "cancer" cells. It simply "tells" them to become normal tissue again. The high capacity of the salamader to regenerate is probably due to the extremely high CO2 levels under which it lives. There is nothing genetically superior about it to allow such abilities to form. Small children have the same abilities and since their gene do not change much over time, the only plausible explanation remaining for the increased disease (and especially cancer) with aging is the universal decline in metabolism. That decline disturbs the ability of the organism to follow its morphogenetic field, and that field guides the proper differentiation of all organs. If the field cannot be followed properly, cancer and all sorts of other degenerative disease follow.

 

[TreasureVibe]

Peat spoke about cancer being a sort of "ad-hoc" organ - regular cells acting weirdly due to poor environmental conditions. If you search for his article where he explains that I think his explanation would be thousand times better than I can offer. One of the most illustrating examples he gives is the one of a salamander who never develops cancer no matter how many tumor grafts are transplanted on it. So, something in the salamander makes those well-developed tumors consisting of fully "cancerous" cells to completely differentiate and turn into normal salamander tissue. The salamander does not dissolve or destroys the transplanted tumors, it does not kill "cancer" cells. It simply "tells" them to become normal tissue again. The high capacity of the salamader to regenerate is probably due to the extremely high CO2 levels under which it lives. There is nothing genetically superior about it to allow such abilities to form. Small children have the same abilities and since their gene do not change much over time, the only plausible explanation remaining for the increased disease (and especially cancer) with aging is the universal decline in metabolism. That decline disturbs the ability of the organism to follow its morphogenetic field, and that field guides the proper differentiation of all organs. If the field cannot be followed properly, cancer and all sorts of other degenerative disease follow.

In the case of niacinamide-resistant cancer:

It starts with a lesion. The lesion is "hard", which means resistant to metabolic means like niacinamide to soften it up fully and differentiate to normal cells again. Even when a tumor is completely shrunk 100%, the lesion stays. This is why so many cases are described as "the cancer (tumor) always comes back)". The lesion is hard, because of nitrogen that the immature cells originally collected. Paradoxically, just like the calcium paradox of Ray Peat, feeding the lesion with alot of nitrogen will soften the lesion, so that it becomes susceptible to metabolic agents again, like niacinamide, and they will subsequently therefore differentiate.

Does the salamander happen to be rich in nitrogen? Or does it have a distinctive or large nitrogen metabolism?

Cancer patients injected with Tumorex, aka l-arginine recall feeling that their tumors softened up, became soft again. Arginine is among more used for mobilization of nitrogen and is a nitrogen donor itself.

What do you think?

I'm not saying one or the other, I'm saying, why not incorporate the two with eachother? For the best chance of success in treatment of the patient.

Salamander Has Algae Living Inside Its Cells
2011

That spotted salamanders and algae live in symbiosis was first noted in the 19th century, and in the 20th century researchers worked out the relationship’s mutual benefits. Salamander eggs provide a nitrogen-rich environment for algae to grow; algae oxygenate the embryos, which develop deformities without them.

Algae invade spotted salamander embryos early in their development, when individuals are just beginning to take shape inside their eggs, as the brain folds up and tissue layers-to-be first organize themselves. As an embryo develops, algae suffuses its body, but most becomes concentrated along its gut and alimentary canal.
https://www.wired.com/2011/04/symbiotic-salamander/

The unique relationship between spotted salamanders and green algae was first documented over a century ago, when it was first noticed that the green tinge of the salamanders' eggs was actually due to tiny algae. Until just a few years ago, most assumed that the green algae was simply living on the outside of the eggs, with the developing salamanders providing the algae with nitrogen, and the algae increasing the concentration of oxygen, helping the embryos grow.
Spotted Salamanders And Green Algae Have A Strange Symbiotic Relationship

Again, nitrogen is implied in the salamander too. In the birth, algae, salamanders are rich in nitrogen.

 

[TreasureVibe]

I might add that Ray Peat even supports the somatid (small micro organism) theory of Naessens, even if he is not aware of it:
The ability to recruit normal cells into a damaged area, the "cancer field," the way normal organs do, shows that tumors can be thought of as organ-like structures, and that knowledge of the organizing principles of normal organs might improve our knowledge of tumors. The idea that cancer is primarily a problem of organization isn't new: Johannes Muller, in the 19th century, and J.W. Orr, and D.W. Smithers, in the 1940s and 1950s, and many others, have suggested that something outside of the individual cell could cause the disorganization.

As well as what I just wrote down, the hardness of cancer:
Something that everyone knows about tumors is that they are harder than the normal tissues in which they appear--they can be identified as lumps. Like the failing heart, they become harder than normal, and like the failing heart, the hardening can proceed to calcification.
The Cancer Matrix

So we have calcification of the lesion/lump, why not nitrogenation? It would resonate with Ray Peat's brilliant calcium paradox, if Naessens' saturating of the cancer cells with nitrogen is the same principle, but then instead of calcium, nitrogen.

"Nitridation" is a heat treating process that diffuses nitrogen into the surface of a metal to create a case-hardened surface. Source: Nitriding - Wikipedia

 

[haidut]

I might add that Ray Peat even supports the somatid (small micro organism) theory of Naessens, even if he is not aware of it:
The ability to recruit normal cells into a damaged area, the "cancer field," the way normal organs do, shows that tumors can be thought of as organ-like structures, and that knowledge of the organizing principles of normal organs might improve our knowledge of tumors. The idea that cancer is primarily a problem of organization isn't new: Johannes Muller, in the 19th century, and J.W. Orr, and D.W. Smithers, in the 1940s and 1950s, and many others, have suggested that something outside of the individual cell could cause the disorganization.

As well as what I just wrote down, the hardness of cancer:
Something that everyone knows about tumors is that they are harder than the normal tissues in which they appear--they can be identified as lumps. Like the failing heart, they become harder than normal, and like the failing heart, the hardening can proceed to calcification.
The Cancer Matrix

So we have calcification of the lesion/lump, why not nitrogenation? It would resonate with Ray Peat's brilliant calcium paradox, if Naessens' saturating of the cancer cells with nitrogen is the same principle, but then instead of calcium, nitrogen.

"Nitridation" is a heat treating process that diffuses nitrogen into the surface of a metal to create a case-hardened surface. Source: Nitriding - Wikipedia

I think the hardness is just fibrosis, which goes back to my link about serotonin and the 5-HT2B "receptor". So, opposing serotonin seems like a more systemic/general way of opposing cancer than supplying nitrogen to specific cells/region. Also, I am really not very keen on the idea of giving cancer cell arginine. One of the most promising recent experiments is with the arginine depleting amino acid L-NAME, and it deprives the tumor of arginine and thus NO. Supplementing glycine seems to do something very similar. So, until I see very serious evidence that arginine is therapeutic I would not supplement with it, especially in people with cancer. Btw, one of methylene blue's primary anti-cancer effects is scavenging NO and inhibiting its de-novo synthesis. Yet another reason to be wary of arginine, as it is the main precursor of NO.

 

[TreasureVibe]

I think the hardness is just fibrosis, which goes back to my link about serotonin and the 5-HT2B "receptor". So, opposing serotonin seems like a more systemic/general way of opposing cancer than supplying nitrogen to specific cells/region. Also, I am really not very keen on the idea of giving cancer cell arginine. One of the most promising recent experiments is with the arginine depleting amino acid L-NAME, and it deprives the tumor of arginine and thus NO. Supplementing glycine seems to do something very similar. So, until I see very serious evidence that arginine is therapeutic I would not supplement with it, especially in people with cancer. Btw, one of methylene blue's primary anti-cancer effects is scavenging NO and inhibiting its de-novo synthesis. Yet another reason to be wary of arginine, as it is the main precursor of NO.

How would one supplement nitrogen without the addition of cancer growth supporting substances like amino acids and without creating NO in the body?

Glycine is used in fermentation btw, and contains nitrogen too.

History and etymology[edit]
Glycine was discovered in 1820 by the French chemist Henri Braconnot when he hydrolyzed gelatin by boiling it with sulfuric acid.[6] He originally called it "sugar of gelatin",[7][8] but the French chemist Jean-Baptiste Boussingault showed that it contained nitrogen.[9]
Source: Glycine - Wikipedia

It was actually called "nitro-glucaric acid" (glucaric meaning glucose) by the French chemist Boussingault.
Source: One Thousand Experiments in Chemistry
Because glycine is made out of gelatine reacting with nitric acid. Something Naessens did too with his injectable solution.

 

[haidut]

How would one supplement nitrogen without the addition of cancer growth supporting substances like amino acids and without creating NO in the body?

Glycine is used in fermentation btw, and contains nitrogen too.

History and etymology[edit]
Glycine was discovered in 1820 by the French chemist Henri Braconnot when he hydrolyzed gelatin by boiling it with sulfuric acid.[6] He originally called it "sugar of gelatin",[7][8] but the French chemist Jean-Baptiste Boussingault showed that it contained nitrogen.[9]
Source: Glycine - Wikipedia

It was actually called "nitro-glucaric acid" (glucaric meaning glucose) by the French chemist Boussingault.
Source: One Thousand Experiments in Chemistry
Because glycine is made out of gelatine reacting with nitric acid. Something Naessens did too with his injectable solution.

Glycine does contain nitrogen but inhibits iNOS and lowers NO. Arginine seems to directly promote tumor growth. I think in advanced cancer cases where all ingested protein is quickly turned into ammonia, the best approach would be to supplement with keto-acids as they would combine with the high ammonia cancer patients have and help synthesize protein. Not sure if you have heard of Peat's famous "potato protein soup" but that is the rationale behind it.
Cancer patients overwhelmingly have negative nitrogen balance due to elevated cortisol, and administering steroids like T, DHT or synthetic AAS like oxandrolone has been shown to reverse that negative balance so if potato protein soup is not an option administering these steroids can reverse the catabolic state and allow regular protein to be eaten.
Some links on arginine and cancer.
Conditionally Essential Amino Acids: Glycine And Arginine
Arginine Depletion May Be A Viable Approach For Cancer
Glycine May Treat Lung, Brain And Other Cancers
https://www.cell.com/cell-reports/pdf/S2211-1247(16)31799-5.pdf

 

[TreasureVibe]

Glycine does contain nitrogen but inhibits iNOS and lowers NO. Arginine seems to directly promote tumor growth. I think in advanced cancer cases where all ingested protein is quickly turned into ammonia, the best approach would be to supplement with keto-acids as they would combine with the high ammonia cancer patients have and help synthesize protein. Not sure if you have heard of Peat's famous "potato protein soup" but that is the rationale behind it.
Cancer patients overwhelmingly have negative nitrogen balance due to elevated cortisol, and administering steroids like T, DHT or synthetic AAS like oxandrolone has been shown to reverse that negative balance so if potato protein soup is not an option administering these steroids can reverse the catabolic state and allow regular protein to be eaten.
Some links on arginine and cancer.
Conditionally Essential Amino Acids: Glycine And Arginine
Arginine Depletion May Be A Viable Approach For Cancer
Glycine May Treat Lung, Brain And Other Cancers
https://www.cell.com/cell-reports/pdf/S2211-1247(16)31799-5.pdf

Yes thanks for the recommendations, but the rationale you're maintaining is that nitrogen is a balance that must be corrected through systemic measures, are there no ways for direct nitrogen supplementation that does not involve amino acids/protein?
Would for example, nitrogenated camphor, or nitrogenated *insert random terpenoid name here* increase NO when taken orally or injected?

Proteins and amino acids contribute to cancer growth and maintenance of tumor life as far as I am aware, and that is something you would like to avoid.

How about nitrogenated coffee?

 

[TreasureVibe]

All cancer treatment, by natural or by conventional means, feels like a work-around, not addressing the root cause but rather symptoms. Even "root causes" spelled out today by both alternative and mainstream experts, are so meaningless. "oxidation" "metabolic dysfunction". It is just the lid of the surface we're scratching. I'm not disagreeing that those are a more general actual definition of what we're seeing from the surface and that addressing those can even lead to curing of cancer, but it doesn't encompass the process of what's actually going down beneath those general phrasings.

Is it really that the body has no natural protective measure against metabolic dysfunction?

@haidut if you drink nitrogenated coffee, will the nitrogen actually get in your blood, or will it come in the blood but go through conversion first and then get converted back to nitrogen, and if you drink nitrogenated coffee, will the nitrogen raise NO in your blood and body?
What are the gases that constitute a cell? Oxygen, nitrogen, carbon? Hydrogen? What happens to a cell when it gets deprived of one of these gases? Cancer is among more,
a problem of (cell) respiration after all, and nitrogen is part of the air we breathe.
Thnx.

 

[TreasureVibe]

Erythrose was historically first extracted from rhubarb, and rhubarb appears to contain another strong anti-cancer substance scientists have found. So rhubarb might be a good anti-cancer food.

RHUBARB can save your life: Ingredient in plant kills half of cancer cells in 48 hours

The anti-cancer substance is called Parietin, or Physcion and is the orange pigment of rhubarb.

Rhubarb also contains another anti-cancer substance, which is popular among Peaters, called emodin:

Rhubarb | Food for Breast Cancer

Rhubarb also contains oxalates though. Oxalates are a carcinogen.