What's Wrong With Second Generation AntiH Compared To Cypro Etc?

[Gametime]

Just got my cyproheptadine on prescription here in the Uk.. doing a bit of reading into them the dementia cases have put me off a bit.. and also why are these antiH's so in the shadow compared to most other Antihistamines's? (At least they are in the Uk)?


Also, What is wrong with a second Generation AntiH like ceterizine etc?? Why are these not peaty? I used to take these all the time a few years back and didn't see a problem with them?

 

[biggirlkisss]

i want to 60mg and it helped me so.

 

[HDD]

Just got my cyproheptadine on prescription here in the Uk.. doing a bit of reading into them the dementia cases have put me off a bit.. and also why are these antiH's so in the shadow compared to most other Antihistamines's? (At least they are in the Uk)?


Also, What is wrong with a second Generation AntiH like ceterizine etc?? Why are these not peaty? I used to take these all the time a few years back and didn't see a problem with them?

Ray Peat Email Advice Depository

 

[jyb]

Just got my cyproheptadine on prescription here in the Uk.. doing a bit of reading into them the dementia cases have put me off a bit..

Never heard of that. Sources?

 

[Gametime]

Never heard of that. Sources?

I actually did a lot of reading into it a few years ago and kind of decided not to take first generations ever.. I just did a simple google search on antihistamine dementia and just picked this one out:
Common anticholinergic drugs like Benadryl linked to increased dementia risk - Harvard Health Blog

 

[Gametime]

Also, if anyone can chime in on the apparent erectile dysfunction/low test side effects that can happen.. would they be permanent etc?

 

[jyb]

I actually did a lot of reading into it a few years ago and kind of decided not to take first generations ever.. I just did a simple google search on antihistamine dementia and just picked this one out:
Common anticholinergic drugs like Benadryl linked to increased dementia risk - Harvard Health Blog

Ah yes, the cholinergic debate. You can read that on this forum people think of anticholinergic as desirable.

 

[DaveFoster]

Ah yes, the cholinergic debate. You can read that on this forum people think of anticholinergic as desirable.

@haidut

Dr. Peat has said that anticholinergics have shown promise in treating some forms of dementia, but what do you think of the statistical link between anticholinergic antidepressants and dementia (even for patients who discontinued these up to 20 years prior to a diagnosis?)

 

[haidut]

@haidut

Dr. Peat has said that anticholinergics have shown promise in treating some forms of dementia, but what do you think of the statistical link between anticholinergic antidepressants and dementia (even for patients who discontinued these up to 20 years prior to a diagnosis?)

All of the adamantane derivatives approved for Alzheimer, and especially memantine, are powerful anticholinergics. So, given the direct intervention trials showing benefit of these drugs I would not put much weight on the epidemiological link. Maybe it was only specific drugs with other mechanisms of action causing this?