Amazoniac
Member
August 2010 Focus - Vitamin A: The Key to a Tolerant Immune System?: Allergy Research Group
"Vitamin A is the key to the gut making the right decisions. When you are deficient in vitamin A, you veer towards a type of effector T cell called TH17 and its production of IL-17—a proinflammatory cytokine, with propensity to causing autoimmune disease. In contrast, when your stores of vitamin A are sufficient, you’ll have enough peripheral naïve T cells converted to T regulatory cells (Tregs) to help maintain tolerance across the immune system. You will be able to quench ‘inappropriate inflammation’ derived from the effector T Cells: TH17, TH1 and TH2.7
The discovery of T cells that secrete IL-17 and other inflammatory cytokines is profoundly important. The TH17 subset is centrally involved in autoimmune disease and is important in host defense at mucosal surfaces.8
Tregs can help control excess IL-17, and retinoic acid is essential to promote Tregs. New research also implicates IL-17 in rheumatoid arthritis; IL-17 may drive the production of harmful auto-antibodies (antibodies to our own tissue) and may trigger and support an inflammatory cascade. We now have a fascinating and emerging area of clinical investigation: finding out if is possible to use vitamin A to actually convert T cells already polarized to an inflammatory subset, back to tolerance. This would allow a restorative use of this nutrient as opposed to preventative only."
"Effector T cells responsible for the adaptive immune responses can have a long life – sometimes years."
couestrogh, coubangh
"With adequate vitamin A our gut is less likely to be chronically inflamed by inappropriate T-cell conversion leading to a myriad of inflammatory diseases.13"
"This [overconsumption of carotenes] may, in fact, partially explain the results from 2 carotene intervention trials...These studies showed a higher incidence of lung cancer in smokers who consumed high doses of beta-carotene."
If someone knows how K2 affect them, please comment. As always, questions should be addressed to burtlancast.
"Vitamin A is the key to the gut making the right decisions. When you are deficient in vitamin A, you veer towards a type of effector T cell called TH17 and its production of IL-17—a proinflammatory cytokine, with propensity to causing autoimmune disease. In contrast, when your stores of vitamin A are sufficient, you’ll have enough peripheral naïve T cells converted to T regulatory cells (Tregs) to help maintain tolerance across the immune system. You will be able to quench ‘inappropriate inflammation’ derived from the effector T Cells: TH17, TH1 and TH2.7
The discovery of T cells that secrete IL-17 and other inflammatory cytokines is profoundly important. The TH17 subset is centrally involved in autoimmune disease and is important in host defense at mucosal surfaces.8
Tregs can help control excess IL-17, and retinoic acid is essential to promote Tregs. New research also implicates IL-17 in rheumatoid arthritis; IL-17 may drive the production of harmful auto-antibodies (antibodies to our own tissue) and may trigger and support an inflammatory cascade. We now have a fascinating and emerging area of clinical investigation: finding out if is possible to use vitamin A to actually convert T cells already polarized to an inflammatory subset, back to tolerance. This would allow a restorative use of this nutrient as opposed to preventative only."
"Effector T cells responsible for the adaptive immune responses can have a long life – sometimes years."
Which is probably why some people only have success with some diets after eliminating the problematic food groups completely for some time, hopefully correct nutrition and only then intruduce them later without problems (GAPS, no-starch diet, SCD, etc).
Some lords also mistakingly take copious amounts of vit D supplements to help their immune system fight the infection but they are probably worsening their situation by disrupting the Vit A/D balance even more; when it was a matter of gut integrity and proper signalling.
And the best way to achieve their balance seems to be eating and living intuitively; however some people are just too detached to make sensible choices, in that case it's safer to take a supplement that already have them somewhat balanced for you.
Some lords also mistakingly take copious amounts of vit D supplements to help their immune system fight the infection but they are probably worsening their situation by disrupting the Vit A/D balance even more; when it was a matter of gut integrity and proper signalling.
And the best way to achieve their balance seems to be eating and living intuitively; however some people are just too detached to make sensible choices, in that case it's safer to take a supplement that already have them somewhat balanced for you.
couestrogh, coubangh
"With adequate vitamin A our gut is less likely to be chronically inflamed by inappropriate T-cell conversion leading to a myriad of inflammatory diseases.13"
"This [overconsumption of carotenes] may, in fact, partially explain the results from 2 carotene intervention trials...These studies showed a higher incidence of lung cancer in smokers who consumed high doses of beta-carotene."
If someone knows how K2 affect them, please comment. As always, questions should be addressed to burtlancast.
