The Influence Of Free Fatty Acids On The Free Fraction Of Thyroid Hormones In Serum As Estimated By

Discussion in 'Scientific Studies' started by paymanz, Sep 16, 2015.

  1. paymanz

    paymanz Member

    Jan 6, 2015

    Thyroid hormones are displaced from their binding proteins in serum during nonthyroidal somatic illness, and FFA have been claimed to contribute. It seems mandatory to evaluate this effect using techniques for the measurements of serum free thyroid hormones in which serum remains undiluted. We measured the effect of 7 common human FFA on the free fraction of T4, T3 and rT3 in serum from healthy subjects using an ultrafiltration technique by which serum is diluted only minimally. In addition we measured the effect of oleic acid on the free fractions of the iodothyronines in pooled serum from healthy subjects and in pooled serum from patients with nonthyroidal illness. All FFA tested were able to displace both T4, T3 and rT3, but to a varying degree, arachidonic and linoleic acid being the most potent ones. A 20% increase in the free fractions of T4, T3 and rT3, respectively, was obtained by adding between 1.7-3.3 mmol/l, 1.3-4.6 mmol/l and 1.0-2.4 mmol/l of the different FFA. A serum pool obtained from patients with nonthyroidal somatic illness was more sensitive to oleic acid than a serum pool obtained from healthy subjects, since 2-3 times less oleic acid was necessary to induce a 20% increase in the free fractions of thyroid hormones. It is concluded that FFA are able to displace both T4, T3 and rT3 from their serum binding proteins in healthy subjects as well as in patients with nonthyroidal illness. However, serum from patients with nonthyroidal illness was more sensitive to the displacing activity of oleic acid than serum from healthy subjects.
  2. burtlancast

    burtlancast Member

    Jan 1, 2013
    Ray right again.
  3. Giraffe

    Giraffe Member

    Jun 20, 2015
    I wondered what this free T3 and free T4 is actually about. Looked it up in Ray Peat's articles...

    Thyroid: Therapies, Confusion, and Fraud
  4. tara

    tara Member

    Mar 29, 2014
    I have wondered before, and this reminds me.
    If thyroxine (T4) is lipophilic, and I make chicken neck stock, is there more thyroxine in the watery stock, or in the floating fat, or in the scummy (emulsified?) part in between? What about the T3?
    I have been discarding the fat and a lot of the scum, and eating all the water-based stock. Am I throwing out the good stuff?