• tca300: I understand this is off topic from what you typically teach, but I was wondering if you have run across any information or learned on your own, things that help people grieve over lost loved ones, and or fear of losing others to death? Thank you!

    Ray Peat: It activates the “helplessness” reactions in the body, stress weakening your own life, and I think it can help to get out of that if you think of your life as a continuation of theirs—the same life, though with fewer bodies.

    Rest in Paradise, Raymond Peat  October 12, 1936 - November 24 2022

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free fatty acids

  1. J

    Free fatty acid suppression by Copper Nicotinate and Salicylates

    According to Ray’s work, lowering free fatty acids seems to be an essential factor in promoting proper health and regeneration, so I thought I’d post a few studies I found. Copper Nicotinate...
  2. haidut

    Lipolysis preferentially releases PUFA from adipose tissue

    ...compared to SFA and/or MUFA. This topic is considered highly controversial in Peat-land, mostly because of the dearth of studies dealing with it. I must have received hundreds of emails at this point criticizing Peat's stance on this issue and claiming that there is no evidence for...
  3. B

    I feel so lost - hair loss as a 26 year old (w/ pictures)

    I have been experiencing immense hair loss since May of this year. Both a receding hairline and intense shedding when I run my fingers through my hair. I have implemented everything under the sun from oysters, aspirin, oxtail, raw liver, methyl blue, cutting training, increasing protein, to...
  4. A

    When should I eat my fat,

    I have heard information about the negative effects of free fatty acids and also mixing carbs and fats causing insulin resistance via the randle cycle. My fat intake is 76 grams and my carb intake 450 grams. I normally have a big breakfast consisting of carbs fat and protein altogether with...
  5. P

    Evidence For Brain Sensing Of Circulating FFA

    A Fall in Plasma Free Fatty Acid (FFA) Level Activates the Hypothalamic-Pituitary-Adrenal Axis Independent of Plasma Glucose: Evidence for Brain Sensing of Circulating FFA Endocrinology. 2012 Aug; 153(8): 3587–3592. Published online 2012 Jun 1. doi: 10.1210/en.2012-1330 PMCID: PMC3404348...
  6. P

    Betaine Lowers FFA And Improve Insulin Sensitivity And Adiponectine Level In High Fat Fed Animal

    Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Endoplasmic reticulum (ER) stress plays a critical role in adipose tissue dysfunction and insulin resistance in a variety of experimental...
  7. P

    Low Carb Diet,FFAs, High Free Tryptophan, Serotonin ,fatigue

    Also the question of "does a high fat meal increase free fatty acid levels?" The answer is yes!it does. Low-Carbohydrate-High-Fat Diet: Can it Help Exercise Performance? Low-carbohydrate-high-fat (LCHF) diets have been used as a means of weight loss and control of symptoms in several...
  8. Drareg

    Inhibition Of Sperm Motility And Agglutination Of Sperm Cells By Free Fatty Acids In Whole Semen

    Interesting....... "The effects of a serial dilution of linoleic acid on human spermatozoa in whole semen was tested on 21 semen samples obtained from 11 normal volunteers. The minimal concentration of linoleic acid required to stop the movement of at least 75% of the moving sperm ranged from 1...
  9. Elchapchapchapo

    Haidut On Insulin Sensitivity / Insulin Resistance

    Insulin resistance is caused by elevated fatty acids (FFA)
  10. D

    Effects Of Exercise On The Fatty-acid Composition Of Blood And Tissue Lipids

    Effects of exercise on the fatty-acid composition of blood and tissue lipids. - PubMed - NCBI Abstract This article reviews the effects of acute and chronic exercise on the fatty-acid composition of animal and human tissues (plasma, skeletal muscle, heart, adipose tissue, liver, artery and...
  11. P

    A Central Role For JNK(inflammation) In Obesity And Insulin Resistance

    A central role for JNK in obesity and insulin resistance. - PubMed - NCBI Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal...
  12. P

    Inflammation Mediates Free Fatty Acid-induced Insulin Resistance

    JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. - PubMed - NCBI Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture...
  13. Bahaa El wazzan


    A low salt diet increases the free fatty acids, leading to insulin resistance, increasing free fatty acids in the blood, and contributing to atherosclerosis (Prada, et al., 2000; Mrnka, et al., 2000; Catanozi, et al., 2003; Garg, et al., 2011) Atherosclerosis is a disease in which plaque...
  14. P

    Is Insulin Resistance A Result Of Impaired Beta Oxidation Or Excessive Beta Oxidation?

    Peat's obviously a big believer that healthy glucose metabolism should be favored over beta oxidation, and that many factors, including PUFA, excessive lypolysis, serotonin, estrogen, cortisol, lactate, and inflammation all steer the body away from oxidative metabolism, leading to even more...
  15. P

    Biotin Decreases Serum Free Fatty Acids

    Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels. - PubMed - NCBI Several studies have shown that pharmacological concentrations of biotin decrease hyperlipidemia. The molecular mechanisms by which...
  16. P

    The Influence Of Free Fatty Acids On The Free Fraction Of Thyroid Hormones In Serum As Estimated By

    http://www.ncbi.nlm.nih.gov/pubmed/3661050 Thyroid hormones are displaced from their binding proteins in serum during nonthyroidal somatic illness, and FFA have been claimed to contribute. It seems mandatory to evaluate this effect using techniques for the measurements of serum free thyroid...
  17. haidut

    Free fatty acids (FFA) as the cause of insulin resistance

    Peat has said this many times, but I think it is nice to see some independent "verification" of that statement, especially given how often it is questioned here on the forum by some. These two studies by the same scientist seem to imply that chronic suppression of free fatty acid elevation...
  18. haidut

    Vitamin B3 Blocks FFA Elevation Caused By Caffeine

    Even though it is a logical finding knowing how niacinamide works, I still wanted to post this since it is one of the few studies looking at the combined effects of Peat substances like niacinamide and caffeine. I guess for simplicity you can assume that taking as much niacinamide as caffeine...
  19. J

    Sleep Loss Increases FFA

  20. haidut

    Elevated free fatty acid cause insulin resistance

    More evidence for the Peat camp that it is elevated free fatty acids (FFA), not sugar, that causes insulin resistance. This study actually looked at niacin, since it is known to induce insulin resistance. The study confirmed that the freely circulating fatty acids (but not fat levels in muscle)...