Telmisartan Withdrawal

[Peatness]

Other thing that help against serotonin and hypertension are niacinamide, ferulic acid, vitamin E.
steamed potato with japanese soysauce and lot's of salt is what I like for upping sodium.

Thank you.

 

[youngsinatra]

For how long have you been taking telmisartan?
Have you reached the max dose of 80mg yet?

 

[Peatness]

For how long have you been taking telmisartan?
Have you reached the max dose of 80mg yet?

It was nearly 2 years at 40mg/60mg

 

[PeskyPeater]

I would recommend from TCM the GABAergic: Atractylodes macrocephala - Bai Zhu
with Ziziphus jujuba which help regulate blood pressure and decrease serotonin overactivity and improve sleep.

 

[Peatness]

Telmisartan-induced lichen planus eruption manifested on vitiliginous skin - PubMed

Telmisartan-induced lichen planus eruption manifested on vitiliginous skin

pubmed.ncbi.nlm.nih.gov

 

[yerrag]

I would recommend from TCM the GABAergic: Atractylodes macrocephala - Bai Zhu
with Ziziphus jujuba which help regulate blood pressure and decrease serotonin overactivity and improve sleep.

Why do you recommend them? Because they worked for you? And if so, what was your context?

 

[PeskyPeater]

Why do you recommend them? Because they worked for you? And if so, what was your context?

I have researched them and other TCM herbs for a hypothyroid friend, with insomnia, leaky gut, PTSD, PCOS.
Those two herbs together can increase the action of GABA and increase the metabolism of serotonin and or excessive dopamine for better sleep. Also useful with withdrawal from drugs, and improve gut function

 

[yerrag]

I have researched them and other TCM herbs for a hypothyroid friend, with insomnia, leaky gut, PTSD, PCOS.
Those two herbs together can increase the action of GABA and increase the metabolism of serotonin and or excessive dopamine for better sleep. Also useful with withdrawal from drugs, and improve gut function

Thanks.

 

[Peatness]

Increased serum creatine kinase due to hypocalcemia in vitamin D deficiency

Increased serum creatine kinase due to hypocalcemia in vitamin D deficiency - PubMed

An 8-year-old boy with vitamin D-deficiency rickets, increased serum creatine kinase (CK), and hypocalcemia is described. At 5 years of age, he was evaluated because of recurrent tonic seizures. He had growth retardation, microcephaly, quadriplegia, mental retardation, and epilepsy. Muscle...

pubmed.ncbi.nlm.nih.gov

 

[Peatness]

Could telmisartan lower vitamin D and suppress the immune system? Just tested vitamin D and for the first time in 10 years my levels are low - 26 ng/mL

Telmisartan (MPKB)

Telmisartan Nuclear receptors and ligands are a class of proteins found within the interior of cells that are responsible for sensing the presence of hormones and certain other molecules. A unique property of nuclear receptors which differentiate them from other classes of receptors is their...

mpkb.org

 

[Peatness]

Taurine and the renal system

Taurine participates in a number of different physiologic and biologic processes in the kidney, often reflected by urinary excretion patterns. The kidney is key to aspects of taurine body pool size and homeostasis. This review will examine the renal-taurine ...

www.ncbi.nlm.nih.gov

Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons - PubMed

Glutamate-induced excitotoxicity has been implicated as an important mechanism underlying a variety of brain injuries and neurodegenerative diseases. Previously we have shown that taurine has protective effects against glutamate-induced neuronal injury in cultured neurons. Here we propose that...

pubmed.ncbi.nlm.nih.gov

The potential health benefits of taurine in cardiovascular disease

Taurine (2-aminoethanesulphonic acid), a sulphur-containing amino acid, is found in most mammalian tissues. Although it can be synthesized endogenously, the major source of taurine is from the diet. Taurine was found to exhibit diverse biological actions, ...

www.ncbi.nlm.nih.gov

The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial - Diabetology & Metabolic Syndrome

Background Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes. Dietary supplementation with taurine may attenuate oxidative stress and inflammatory responses in T2DM as well as...

dmsjournal.biomedcentral.com

 

[youngsinatra]

Could telmisartan lower vitamin D and suppress the immune system? Just tested vitamin D and for the first time in 10 years my levels are low - 26 ng/mL

Telmisartan (MPKB)

Telmisartan Nuclear receptors and ligands are a class of proteins found within the interior of cells that are responsible for sensing the presence of hormones and certain other molecules. A unique property of nuclear receptors which differentiate them from other classes of receptors is their...

mpkb.org

Do you supplement vitamin D?

Your levels are actually not that bad in my opinion!

 

[Peatness]

Do you supplement vitamin D?

Your levels are actually not that bad in my opinion!

Yes I do. That's the lowest level I've had in nearly 10 years. Although 26 is not that low It's unusually low for me. ddjd posted this quote about t3 by Dr Peat today. Note that he suggests a level of around 50ng/ml

"It’s anabolic generally, but especially for protein synthesis, and by lowering stress hormones it can shift body composition toward muscle and bone. Chronically underweight people are the most likely to gain weight. If calcium and vitamin D are deficient, protein metabolism becomes catabolic, with a shift toward fat synthesis. Low fat milk, about two quarts/day, and keeping serum vitamin D around 50 ng/ml, helps to prevent excess fat deposition." Ray Peat, PhD

If I didn't have any symptoms I wouldn't worry to much of that level. I'm hoping for a hot summer.

 

[youngsinatra]

Yes I do. That's the lowest level I've had in nearly 10 years. Although 26 is not that low It's unusually low for me. ddjd posted this quote about t3 by Dr Peat today. Note that he suggests a level of around 50ng/ml

"It’s anabolic generally, but especially for protein synthesis, and by lowering stress hormones it can shift body composition toward muscle and bone. Chronically underweight people are the most likely to gain weight. If calcium and vitamin D are deficient, protein metabolism becomes catabolic, with a shift toward fat synthesis. Low fat milk, about two quarts/day, and keeping serum vitamin D around 50 ng/ml, helps to prevent excess fat deposition." Ray Peat, PhD

If I didn't have any symptoms I wouldn't worry to much of that level. I'm hoping for a hot summer.

How much vitamin D do you take on a daily basis?
Was your vitamin D level in the desired range beforehand?

 

[Peatness]

How much vitamin D do you take on a daily basis?
Was your vitamin D level in the desired range beforehand?

Around 5000 sometimes 10,000 daily. My previous test was 38ng and the one before that was 45ng

 

[youngsinatra]

I couldn’t find any literature on telmisartan‘s effect on vitamin D homeostasis, sadly.

Around 5000 sometimes 10,000 daily. My previous test was 38ng and the one before that was 45ng

Wow so you actually take quite a bit of vitamin D.
Really strange that this intake does not lead to higher vitamin D levels.

I think there are lots of factors that can cause a sort of vitamin D resistance - such as seen in some cases of EBV-infection for example.

 

[youngsinatra]

From personal experience with friends and family members I can say that some of them respond relatively poorly to vitamin D supplementation at maintenance doses, but respond well to an short-term initial high-dose saturation phase, followed by normal supplemental dosages afterwards.

Maybe something to try out! :)

 

[Peatness]

From personal experience with friends and family members I can say that some of them respond relatively poorly to vitamin D supplementation at maintenance doses, but respond well to an short-term initial high-dose saturation phase, followed by normal supplemental dosages afterwards.

Maybe something to try out! :)

That's just it - I have always maintained higher levels at those doses - Why the sudden dramatic decrease - is it telmisartan or something else? I'm just trying to understand what changed. It could be reduced sun exposure last summer. Could injury lower the levels? These are questions I am toying around we. Meanwhile I'm supplementing extra. Telmisartan tanks zinc levels so it could be telmisartan

 

[Peatness]

The vitamin D receptor (VDR) binds zinc, and the activity of vitamin D dependent genes in cells is influenced by intracellular zinc concentrations. Zinc help vitamin D to work inside the cells. It is also important to ensure that the calcium from foods or supplements is used in your bones.

The relationship of serum vitamin D and Zinc in a nationally representative sample of Iranian children and adolescents: The CASPIAN-III study

Background: Vitamin D (VitD) deficiency is a common worldwide problem. Some previous studies have shown that both Zinc (Zn) and VitD deficiency are prevalent in Iran. This study aimed to assess the relationship of serum Zn and vitamin D levels in a nationally ...

www.ncbi.nlm.nih.gov

 

[youngsinatra]

Where can I read about telmisartan inducing zinc deficiency?