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Taking Ibuprofen Every Day Could Extend Your Life by up to 12 YEARS
- Thread starter charlie
- Start date
burtlancast
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- Joined
- Jan 1, 2013
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- 3,263
Mmm..
Worms and flies are not exactly the kind of animals you would like to base yourself on for such a claim.
How difficult would it be to experiment on rats ?
Worms and flies are not exactly the kind of animals you would like to base yourself on for such a claim.
How difficult would it be to experiment on rats ?
Further studies led to the conclusion that ibuprofen inhibits uptake of tryptophan and other amino acids by the cell. Tryptophan is an amino acid that’s an essential building block of proteins, but also involved in the regulation of “the calming hormone,” serotonin, and it is vital for health across organisms.
The presence of i buprofen seems to disrupt the enzyme Tat2 permease, which helps a cell take in that oh-so-necessary tryptophan. However, lifespan for the yeast still saw a significant jump even when that enzyme was deactivated. (In these conditions, tryptophan levels were reduced but not to zero, since the yeast cell can make tryptophan internally.)
Furthermore, when the scientists stabilized the enzyme activity while exposing the yeast to ibuprofen, the yeast’s lifespan did not increase — meaning the ibuprofen was doing something else to boost the cell health when the tryptophan wasn’t.
Deactivating the permease, which rapidly takes in amino acids like tryptophan, has an unexpected effect on cell aging. “Ibuprofen slows the transport of amino acids, and the protein synthesis slows down,” Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to increased longevity across all the species. After yeast, the same bump was shown in fruit flies and worms.
This study is the first to identify a potential new drug candidate to target aging: ibuprofen. According to Kennedy, if the drug had the same effect in humans, something that needs to be tested, it could mean a significant enhancement of healthy aging.
https://www.yahoo.com/health/this-drug- ... 14917.html
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Some scientists interpret 'anti aging' as 'slow metabolism'
The presence of i buprofen seems to disrupt the enzyme Tat2 permease, which helps a cell take in that oh-so-necessary tryptophan. However, lifespan for the yeast still saw a significant jump even when that enzyme was deactivated. (In these conditions, tryptophan levels were reduced but not to zero, since the yeast cell can make tryptophan internally.)
Furthermore, when the scientists stabilized the enzyme activity while exposing the yeast to ibuprofen, the yeast’s lifespan did not increase — meaning the ibuprofen was doing something else to boost the cell health when the tryptophan wasn’t.
Deactivating the permease, which rapidly takes in amino acids like tryptophan, has an unexpected effect on cell aging. “Ibuprofen slows the transport of amino acids, and the protein synthesis slows down,” Kennedy tells Yahoo Health. Slower protein synthesis equals slower aging — which equates to increased longevity across all the species. After yeast, the same bump was shown in fruit flies and worms.
This study is the first to identify a potential new drug candidate to target aging: ibuprofen. According to Kennedy, if the drug had the same effect in humans, something that needs to be tested, it could mean a significant enhancement of healthy aging.
https://www.yahoo.com/health/this-drug- ... 14917.html
-------
Some scientists interpret 'anti aging' as 'slow metabolism'
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