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PUFA Inhibit Progesterone Production And Thus Drive/cause Menopause

Discussion in 'Scientific Studies' started by haidut, Mar 14, 2018.

  1. haidut

    haidut Member

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    Peat wrote in a few of his articles that menopause is largely driven by a deficiency of progesterone and mentioned several anecdotes of women in their 50s and 60s getting their periods back after supplementing with large doses progesterone. In one of his articles he said that PUFA and estrogen are the main drivers of ovarian "failure" and that opposing estrogen increases reproductive lifespan.
    This study below shows that PUFA (in this case EPA and its metabolites) directly inhibits progesterone production in the ovaries, and once again the magnitude of the effects was dependent on the unsaturation level of the fatty acid. As usual, saturated fatty acids did not have detrimental effects.
    One statement from the study that drew my attention is that PUFA may be able to bind to the LH receptor and behave as antagonist. This would have the effects of raising serum LH and FSH, and this rise in LH/FSH has been observed in both menopausal women and men with "andropause". Thus, the decline in steroidogenesis may be at least partly due to PUFA antagonizing the gonadotropin receptors in the testicles and ovaries, which makes them insensitive to the pituitary signals (LH/FSH) to produce steroids. Thus, depleting PUFA may be able to restore steroidogenesis without other pharmacological interventions or maybe even thyroid supplement.

    https://www.ncbi.nlm.nih.gov/pubmed/1335585
    "...Based upon the observed reduction in serum concentrations of progesterone and duration of the estrous cycle it is apparent that injection of methyl 12,13-diHEPE directly into the ovarian artery was more effective than methyl EPA in altering luteal function in ewes. Responses of luteal slices to LH and 8-Br-cAMP after in vitro exposure to 12,13-dill EPE and docosatetraenoic acid provided further further insight regarding the site of action of these unsaturated fatty adds. Kaltenbach et al. (20) have demonstrated that LH enhances secretion of progesterone from ovine luteal tissue in vitro. Cyclic AMP has been shown to activate cholesterol esterase and therefore appears to be an important point of regulation of steroidogenesis (21). Data from the in vitro study suggest that the suppressive effect of 12,13-diHEPE on luteal function may be exerted at the level of the plasma membrane and not at a distal intracellular site beyond the production of cAMP. This proposed site of action of 12,13-diHEPE is supported by results of the study in which luteal tissue was incubated with this labeled fatty acid. These latter data revealed that the majority of the isotopically labeled fatty acid was associated with the plasma membrane of luteal cells. However, the possibility that 12,13-diHEPE also acts at other sites within the cell cannot be entirely excluded. Arachidic acid, 12,13-diHEPE and EPA are of equal chain length but 12,13- diHEPE and EPA are polyunsaturated and characterized by the presence of five double bonds. Thus, it appears that the ability of 12,13-diHEPE and EPA to attenuate progesterone secretion and(or) cause premature luteal regression was dependent in part upon their unsaturation. However, the greater effectiveness of 12,13-dill EPE compared with EPA in suppressing luteal function may be attributed to either the position of the third double bond and(or) the hydroxyl groups located at carbons 12 and 13 of the molecule. The observed in vivo effects of methyl 12,13-diHEPE and methyl EPA on ovine corpus luteum function are similar to those evoked by methyl sterculic acid, a 19 carbon cyclopropenoid fatty acid of plant origin. Administration of this fatty acid to nonpregnant ewes reduced serum concentrations of progesterone and caused premature luteal regression (15).

    "...The existing data suggest that 12,13-diHEPE interferes with the ability of the luteal cell to respond to LH. The precise mode of action of 12,13-diHEPE in accomplishing this feat is unknown. However, it is speculated that 12,13-diHEPE may interact directly with the LH receptor making it inaccessible to the ligand. Cortell et al. (22) reported that methyl sterculic acid suppressed ovine luteal function by interfering with the synthesis and(or) recycling of the LH receptors. Alternatively, 12,13-diHEPE may be incorporated into the luteal plasma membrane, resulting in reduced membrane fluidity. Such a change in membrane characteristics could hinder LH receptor associated G-protein mobility and hence subsequent activation of adenylate cyclase. Indeed, a liquid to gel phase transition has been shown to occur in rat luteal cell membranes early in luteal regression (23). Such changes in the state of the plasma membrane have been shown to affect the mobility of membrane proteins (24). The results of this study indicate that natural fatty acids of unique structure exist that may be useful agents for regulating the life span of the corpus luteum in various mammalian species."
     
  2. Vinero

    Vinero Member

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    Ray said in one interview that EFA deficient animals stay in the puberty stage for most of their life, producing large amounts of progesterone and testosterone.
     
  3. Lucha

    Lucha Member

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  4. jandrade1997

    jandrade1997 Member

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    Very interesting. I recall a podcast a while back where Peat says that dementia is directly related to LH, and that animals without LH never became demented. Wouldn’t the fact that EPA antagonizes the LH receptor suggest that it should be helpful for dementia, even if degenerative in other ways?
     
  5. ImprovingDaily

    ImprovingDaily Member

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    "One statement from the study that drew my attention is that PUFA may be able to bind to the LH receptor and behave as antagonist. This would have the effects of raising serum LH and FSH, and this rise in LH/FSH has been observed in both menopausal women and men with "andropause".

    LH antagonism would lead to an increase in LH production, probably from the LH not sensing the LH present due to EPA and other fatty acids antagonizing the receptor. This leads to more LH accumulating. So I'd say no, EPA isn't helping, it's actually directly hurting.
     
  6. jandrade1997

    jandrade1997 Member

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    Well yes, it leads to a compensatory increases in LH by blocking its effects at the cell. This is similar to how anti-serotonin drugs can lead to increased serum serotonin, due to blocking serotonin receptors/response.
     
  7. ImprovingDaily

    ImprovingDaily Member

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    Right, but I still think it's detrimental to have an excess of LH. The body doesn't sense it but I think it still probably does some sort of damage. Im thinking of it like insulin resistance, the insulin is there, the body's just not sensing it for whatever reason.

    Idk enough about this, I was just quoting what Haidut said and explaining it the way I understood it. I could be wrong. Anyone else wanna chime in?
     
  8. benaoao

    benaoao Member

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    Damn, another kick in the nuts from animal fats.

    LH going medium to high range is a sign of desensitized pituitary IMO.
     
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