hypogonadism

  1. joe

    Raising Testosterone with Enclomiphene

    Noob here. Does anyone have personal experience with Enclomiphene-citrate, treating hypogonadism? It seems like a relatively safe way to raise testosterone, but I have read so many mixed reviews and reported sides (raised E2, accelerated MPB, gyno) and would like to hear from people in this...
  2. haidut

    Raising DHT levels even only in the brain reverses systemic atherosclerosis

    As my readers know, I have been a fan of the strong, non-aromatizable androgen DHT for a long time. One of the first signs for me that DHT is beneficial was the uniform and relentless propaganda against that steroid by mainstream medical publications, despite the obvious (and increasing)...
    • haidut
    • Thread
    • atherosclerosis brain cvd dht dihydrotestosterone hypogonadism inflammation liver testosterone
    • Replies: 16
    • Forum: Scientific Studies
  3. TruffleGnocchi

    Advice wanted for TRT (not seeking medical advice)

    An older person I know has non-functioning testosterone production, zero production from balls. I got him some testosterone, different esters, will recommend using shorter esters daily but bought longer esters if he will insist on not doing daily injections. Also got him exemestene. My question...
    • TruffleGnocchi
    • Thread
    • aromatase aromatase inhbitor cancer esters estrogen exemestene hormone replacement therapy hypogonadism testosterone trt
    • Replies: 7
    • Forum: Hormones
  4. TruffleGnocchi

    Why is male HRT so easy, compared to female HRT?

    Hello everyone. I wanted to ask via a reply to this post: If Estrogen Is So Bad, Why Does It Immediately Help but cannot because of new account restriction, so I'm making this, I hope it's in the right topic. Why is it that a lot of older men just do Testosterone + AI or Testosterone only and...
    • TruffleGnocchi
    • Thread
    • anti-aging estrogen hormones hrt hypogonadism menopause perimenopause testerone vaginal discomfort womens health
    • Replies: 4
    • Forum: Thyroid and Hormones
  5. haidut

    Atherosclerosis linked to high estrogen/cortisol/serotonin, low androgens

    The findings of the study are not surprising, but I wanted to post it on the blog since it is one of the few studies I have seen that examined more than one of the "sickness" mediator levels in a major chronic conditions such as cardiovascular disease (CVD), and found all of them to be elevated...
    • haidut
    • Thread
    • 5-ht atherosclerosis cortisol cvd estrogen hypogonadism pulmonary disease serotonin
    • Replies: 0
    • Forum: Scientific Studies
  6. Doludolu

    Primary/Secondary hypogonadism. Natural testosterone boosting protocols. Clomid (clomiphene citrate)

    Hello, I wanted to ask about mainly primary, but more secondary hypogonadism, and there can be many causes. But situation-wise, I had that from teenage years, where both LH would be on the lower side, testosterone as well, estrogen as well. Then starting more healthy, testosterone-boosting...
    • Doludolu
    • Thread
    • clomid hypogonadism low t testosterone
    • Replies: 10
    • Forum: Male Issues
  7. haidut

    Low testosterone (T) may drive kidney and liver disease (NAFLD) in men

    As many of my readers know, the "normal" range for T has been changed multiple times over the last several decades and each new iteration shifts both the lower and upper limit of the "normal" range downwards. In other words, a male with serum T in the 300 range would be considered "healthy" by...
    • haidut
    • Thread
    • ckd diet hypogonadism kidney liver nafld stress testosterone
    • Replies: 0
    • Forum: Scientific Studies
  8. haidut

    Hypogonadism in older males due to low OXPHOS

    I suspect many readers will simply say "duh!", but believe or not the origin of age-related hypogonadism in males is still considered unknown. Most endocrinologists have discovered experimentally that treating their patients with SERM or AI drugs restores androgens to youthful levels, but the...
    • haidut
    • Thread
    • aging co2 hypogonadism male metabolism oxphos precursor testosterone
    • Replies: 9
    • Forum: Scientific Studies
  9. haidut

    Age-related steroid deficiency may be treatable with niacinamide

    The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...
    • haidut
    • Thread
    • aging androgen dry eye eye hypogonadism meibomian nad niacinamide nicotinamide nicotinamide mononucleotide nicotinamide riboside nmn nr steroidogenesis
    • Replies: 15
    • Forum: Scientific Studies
  10. haidut

    Fasting / stress decimate gonadal steroidogenesis, with no effect on blood cortisol

    A very interesting and very "controversial" (read: inconvenient truth) study, since it shows beyond reasonable doubt that even brief (4 days) fasting is a form of severe stress, at least when it comes to endocrine health. The study may also provide answers to various endocrine "mysteries"...
    • haidut
    • Thread
    • androgen atrophy cortisol fasting gonads hypogonadism stress
    • Replies: 15
    • Forum: Scientific Studies
  11. S

    Gluten free diet modulates my constipation and ED

    I randomly decided to not eat any wheat. Noticed nothing that day. The next day: No morning grog Morning wood (unusual for me) No daytime sleepiness Pooped 3 times that day Only had to wipe 2 or 3 times Erections are Enzyte-tier and on time My scrotum now hangs my balls. (My scrotum normally...
    • steel_reserve
    • Thread
    • circadian rhythm constipation erectile dysfunction gallstones gluten hypogonadism narcolepsy
    • Replies: 6
    • Forum: Experiments
  12. haidut

    Stress ups cortisol/estrogen/prolactin, drops DHT, causes male infertility and prostate issues

    If you try to discuss infertility with a fertility/reproductive specialist or an endocrinologist, and mention that chronic stress may be a factor in infertility, you will probably get laughed out of the room. This is not just speculation. This exact same thing happened to several friends and...
    • haidut
    • Thread
    • androgen aromatase cortisol dht estrogen fertility hypogonadism infertility prolactin stress
    • Replies: 0
    • Forum: Scientific Studies
  13. haidut

    Low DHT can cause hypogonadism symptoms even in eugonadal men

    Seemingly contradictory title, but the study findings are pretty clear. Namely, even in males with normal testosterone levels there is a direct inverse relationship between DHT levels and symptoms of hypogonadism such as sexual dysfunction and "aging male" syndrome. For every 10% increase in DHT...
    • haidut
    • Thread
    • aging androgen dht erectile dysfunction eugonadal hypogonadism sexual dysfunction
    • Replies: 1
    • Forum: Scientific Studies
  14. noqcks

    Solving my hormonal issues (with a SERM?)

    Im going to be honest. I have no ******* idea how the endocrine system works, which is why I'm reaching out for help. I've had gynocomastia since around 16 years of age and have never been able to rid myself of it. Additionally, I seem to have some interesting things going on with LH/FSH...
  15. S

    Kiwi modulates my secondary narcolepsy and hypogonadism symptoms

    All my life I have struggled with sleep attacks during the day. Going Peaty helped me avoid these attacks during the day (making me employable), but in the afternoon and evening they occur at least once. They occur enough that I really can't get involved with things outside of family...
  16. haidut

    Oral pregnenolone as hormone replacement therapy (HRT) in humans

    As many of my readers know, the first step in steroid synthesis is the so-called "side-chain cleavage", which converts cholesterol into pregnenolone (P5). That step is known as the rate-limiting step in the steroid cascade, and its function depends on the redox status and ATP levels. In other...
    • haidut
    • Thread
    • growth hormone hgh hrt hypogonadism oral p5 pregnenolone steroidopenia
    • Replies: 43
    • Forum: Scientific Studies
  17. haidut

    Low energy production (glucose metabolism) may cause andropause

    As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...
    • haidut
    • Thread
    • aging andropause energy glucose hypogonadism metabolism steroidogenesis testosterone
    • Replies: 0
    • Forum: Scientific Studies
  18. haidut

    Endotoxin Has A G.E.L.D.I.N.G Effect, Causes Obesity And Hypogonadism

    A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable...
    • haidut
    • Thread
    • castration diet endotoxin gelding high-fat hypogonadism inflammation leydig lps obesity tlr tlr4
    • Replies: 34
    • Forum: Scientific Studies
  19. haidut

    Endocrine Disruptors In Sunscreen Absorb Systemically And Persist For Days

    So much for the safety of sunscreen. Of course, the article immediately goes on the defensive and warns against stopping sunscreen. It even includes gems like "The sun is the real enemy here" and keeps repeating the mantra that it is all about risk-benefits analysis. Yet, even MSM is forced to...
    • haidut
    • Thread
    • absorb avobenzone birth defects ecamsule endocrine disruptor hypogonadism ingredients low testosterone octocrylene oxybenzone skin sunscreen systemic toxic transdermal
    • Replies: 6
    • Forum: Scientific Studies
  20. haidut

    CNN News - Running Lowers Testosterone In Males

    When news like this features on CNN, it is becoming obvious that something it not right with the official recommendations for regular (endurance) exercise as the best way to ward off CVD, cancer, brain diseases, osteoporosis, etc. The CNN piece also states that vitamin D supplements, weight...
    • haidut
    • Thread
    • concentric endurance exercise hypogonadism pufa running saturated fat sfa testosterone vitamin d vitamin d3 weight lifting young young males
    • Replies: 63
    • Forum: Scientific Studies
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