1. C

    Aging Of A 53 YO Male After 25yrs of Dutasteride 35yrs Oral Steroids + No Testosterone Or DHT

    On top of suppressing his natural testosterone production to nothing until age 51 by taking oral steroids, he suppressed his dht to about zero by taking a full dose of dutasteride. He added 125mg of testosterone at age 51 and used to take aromatase inhibitors when he was taking growth hormone...
  2. blackface

    Ordering from PureBulk to EU - avoiding customs

    Hello guys, I would like to order the DHEA powder from PureBulk website. The thing is that its not allowed in my country and my first package to EU was already seized ones. Now I want to try it again. But I have to figure it out how to do it. I want to obtain the DHEA powder and avoid customs...
  3. J

    Sourcing DHT gel for gyno?

    Hi, I’ve been doing research on topical DHT gel use to shrink gynecomastia in males. I came across this study and thought I will give it a try on my pre existing gyno which I have had since puberty. I’m 26 btw. Can anyone point me in the right direction for a source? Thanks
  4. Jonnie

    Experience with micronized T base?

    So I recently ordered some micronized T base from PPL (still hasnt arrived it’s been 5 weeks.) When and if it does arrive I’d like to test the stuff to check if it is what it’s supposed to be but it seems exceptionally hard to find a commercial lab in Holland that does tests. Anyone have any...
  5. Cameron

    11 keto steroids major human steroids in gonads

    Interesting article.. I was curious anyones good or bad experience with 11 keto dht? Human studies with supplementing it are lacking. An androgen found in fish but also produced by the gonads clearly and potently “Expression of...
  6. Lokzo

    Morning After Pill For Hormonal Re-Set In Men?!

  7. Mauritio

    Cistanche increases steroidogenic enzymes, lowers NO, helps osteoporosis and Alzheimer's

    I posted these studies in another thread, but I feel they deserve their own thread as they show that cistanche is helping the body on a systemic level. A few new studies on cistanche tubulosa: This one shows that cistanche increases biosynthesis of testosterone by increasing important...
  8. Lokzo

    Dihydrotestosterone In Amyotrophic Lateral Sclerosis—The Missing Link?

    Objective Testosterone has been postulated to be involved in ALS causation. Materials and methods CSF levels of free testosterone and dihydrotestosterone were measured in 13 ALS patients [7 males, 6 females] and 22 controls [12 males, 10 females]. Results CSF free testosterone levels did not...
  9. Gohan

    Topical Steroids

    Can you make steroids topically bio available (cream/oil/dmso)? Talking about things like Masteron/EQ/Tren etc? Do they have to be no ester? Whats their bioavailability compared to injectables like this? I know they are unhealthy, just wanna know.
  10. haidut

    PUFA Inhibit Progesterone Production And Thus Drive/cause Menopause

    Peat wrote in a few of his articles that menopause is largely driven by a deficiency of progesterone and mentioned several anecdotes of women in their 50s and 60s getting their periods back after supplementing with large doses progesterone. In one of his articles he said that PUFA and estrogen...
  11. haidut

    Acetaminophen (Tylenol) Depletes DHEA-S And Other Sulfated Steroids

    It is well-known that in animal studies acetaminophen has a potent anti-androgenic and feminizing effect. In some animal models it also reliably causes autism-like symptoms. Given its widespread use and heavy marketing by hospitals, especially to pregnant women (due to its lack of effect on...
  12. haidut

    Cells Have Memory, And Memories Of Past Conditions Affect Future Response

    This study looks at a concept that Peat has written a lot about and which has been largely ignored by mainstream medicine (in favor of genetic explanations) - epigenetic cell memory. The study only looked at muscle cells but there is no reason to believe the same mechanism is not present in...
  13. BigYellowLemon

    Effects Of Morphine Dependence And Withdrawal On Levels Of Neurosteroids In Rat Brain

    Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. - PubMed - NCBI It's a rat study but I think the results are applicable to humans. "The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG)...
  14. L

    The Regulation Of Steroid Action By Sulfation And Desulfation

    Nice state of the arte review about this overlooked but crucial mechansism of steroidal action:
  15. haidut

    Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

    I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...
  16. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men
  17. haidut

    Unsaturation = Estrogenic, Saturation = Androgenic

    Most people on the forum have read Peat's articles on PUFA and its great synergism with the estrogenic hormones. Peat has written that saturated fats have effects opposite to those of PUFA and there are studies showing feeding saturated fat increases androgen synthesis. I have been researching...
  18. S

    Hyperglycaemia Decreases All Adrenal Steroids Except DHEA-S By 47-66%

    Hyperglycaemia acutely decreases circulating dehydroepiandrosterone levels in healthy men. - PubMed - NCBI Over the past two decades, an abundant literature has focused on the adrenal androgens dehydroepiandrosterone sulphate (DHEAS) and dehydroepiandrosterone (DHEA) and their relation with...
  19. haidut

    Multiple Sclerosis (MS) Can Be Caused Quite Easily By Change In Hormones

    If you ask a neurologist she/he will tell you that nobody knows the cause of MS, and if you ask about the role of hormones the doctor will probably give you blank stare and flatly deny that they have a causative or therapeutic role (except for cortisol as acute treatment). Ray, on the other...
  20. haidut

    PPI Drugs (anti GERD) Powerfully Inhibit Steroidogenesis

    I have always been suspicious of PPI drugs. There are many reasons for it, including the falsified clinical trial data to conceal increased risk of gastric cancer, the idiotic premise that gastric acid increases with age, the kidney failure side effects, and the calcium/magnesium depletion being...
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