PUFA promote torpor / hibernation, decrease lifespan

haidut

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Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly controlled amounts/seasons) and universally avoided by non-hibernating ones (when given the choice). Considering we humans have not yet turned into marmots (a hibernating animal) I think it would behoove us to follow the lead of our non-hibernating brethren if we want to keep our health. As far as a mechanism of action, it appears that PUFA interferes with the activity of the electron transport chain complex, specially complex I & II (dependent on CoQ10). In addition to this being a direct evidence of the metabolism-inhibition effects of PUFA, it also suggests that PUFA are powerful inducers of reactive oxygen species (ROS) generation (as another post of mine recently discussed) independently of their peroxidation potential. Perhaps surprisingly, the MUFA oleic acid apparently also promotes torpor when present in high amounts in the diet and in some cases it could fully compensate for the lack of PUFA in the diet when it comes to induction of torpor/hibernation. Yet another reason to not overindulge in all those overpriced (and often fake) imported olive oils sold at the local organic store. Finally, the study references evidence that maximum lifespan is inversely correlated to omega-3 cellular content despite the widely quoted "rate of living" theory of aging - i.e. organisms with higher PUFA tissue content have lower metabolism and shorter lifespan.

https://journals.physiology.org/doi/full/10.1152/ajpregu.00688.2007
"...To date, there has been no systematic experimental study on the effects of various ratios of n-6/n-3 uptake on hibernation or torpor patterns. However, positive effects of PUFA-enriched diets on the propensity for torpor, minimum body temperature, metabolic rate, and torpor bout duration were all caused by diets with increased linoleic acid content, that is, the major PUFA of the n-6 class (55). These positive effects of high dietary linoleic acid content, in particular, on torpor bout duration and torpor propensity, were observed in several genera of daily heterotherms (Peromyscus, Phodopus, Sminthopsis) and hibernators (Acrobates, Cynomys, Tamias, Spermophilus, Marmota) (55). There is also some evidence indicating that high amounts of dietary oleic acid (C18:1 n-9) can partly (31) or even fully (26) compensate for low n-6 intake and that this MUFA also leads to increased torpor bout duration and decreased body temperatures during hibernation."

"...Another effect of n-6 PUFA-enriched diets is increased torpor bout duration, which can be profound (e.g., 21, 29, 30, 72). Since torpor bout duration seems to be linked to energy turnover in the hibernating state (27, 29, 31), minimizing the lowest tolerated body temperature, and hence metabolism, by establishing high n-6/n-3 ratios in heart phospholipids would also explain their effect on the length of torpor bouts."

"...The translation and transcription of SERCA, as of all proteins, are sharply and acutely downregulated during entrance into torpor and only resumed during arousals. (10, 35, 77, 78). Degradation of proteins, on the other hand, is also decreased several-fold at low body temperatures but may not be entirely blocked (overview in Ref. 78). During torpor entrance, protein damage may be even increased because of the stress of severe changes in metabolism (78). "

"...An undisputed adverse effect of high PUFA content on membranes is their high susceptibility to peroxidation by radical oxygen species (ROS), which are generated during mitochondrial respiration (40, 46). Lipid peroxidation leads to deleterious products such as reactive aldehydes that cause damage to membranes as well as enzymes, and inhibit DNA and protein synthesis (overview in 40).Therefore, it has been argued that optimal levels of PUFA intake in hibernators result from a trade-off between their beneficial effects on cellular function during hypothermia, and peroxidation-related cellular damage (e.g., 24, 55). This trade-off is thought to be the underlying reason why some hibernators reduce torpor when provided with large amounts of PUFAs (56), or, when given the choice, do not simply maximize linoleic acid intake, but appear to ingest an “optimal,” intermediate amount (24)."

"...Specifically, high ratios of n-6 to n-3 PUFAs increase the activity of the Ca2+-Mg2+ pump in the sarcoplasmic reticulum of the heart (SERCA) and counteract Q10 effects on SERCA activity at low tissue temperatures."

"...In summary, our analysis supports the view that proper Ca2+ handling of cardiac myocytes is the crucial adaptation that separates hibernators and daily heterotherms from homeothermic mammals (3, 81). Further, we propose that the key to understanding the impact of PUFAs on hibernation is to recognize the opposing effects of n-6 and n-3 PUFAs on SERCA activity in cardiac membranes, and the risk of low n-6/n-3 ratios for cardiac arrest during hypothermia. One might be tempted to think that the effects of these essential fatty acids are quite specific and limited to the particular problem of maintaining cellular function at low body temperatures. Arguably however, this is not the case. For instance, we recently found that n-6 to n-3 PUFA ratios in skeletal muscle phospholipids are closely associated with (body-size corrected) differences in maximum running speed in mammals, an effect which may be also mediated via their effects on SERCA activity (64). Further, n-6 to n-3 PUFA ratios appear to be the only aspect of membrane fatty acid composition that is clearly associated with maximum life span across mammals (76). Thus, it seems that the ratio of n-6 to n-3 PUFAs in biological membranes may have important general physiological functions and can create crucial trade-offs that go far beyond their effect on seasonal adaptation and hibernation alone."
 

egoy

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What would be the best & fastest way to remove PUFA completely from body? I remember you did a thread showing that a fat-free diet would achieve this in 31 days but that is a little extreme I'd say and probably unhealthy too. Is there any way at all someone could achieve this more safely?
 

Missenger

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Based off what he eats lean, clean complete animal protein seem to be his answer, the same with Ray, with a tsp of refined coconut oil here or there depending on your allergy tolerance to facilitate weight/pufa loss.
 

OccamzRazer

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What would be the best & fastest way to remove PUFA completely from body? I remember you did a thread showing that a fat-free diet would achieve this in 31 days but that is a little extreme I'd say and probably unhealthy too. Is there any way at all someone could achieve this more safely?
You could swap out all dietary fats for the most saturated fats (MCT oil, hydrogenated coconut oil, suet, etc), while keeping fat intake low-moderate.

Sterculia oil may also help saturated fat displace PUFA in fat stores. I'd be curious to know what Haidut thinks about it.
 

egoy

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You could swap out all dietary fats for the most saturated fats (MCT oil, hydrogenated coconut oil, suet, etc), while keeping fat intake low-moderate.

Sterculia oil may also help saturated fat displace PUFA in fat stores. I'd be curious to know what Haidut thinks about it.
I was thinking about doing a 31 days coconut water fasting to deplete all PUFAs but it might be dangerous as other members said they got worse
 

OccamzRazer

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I was thinking about doing a 31 days coconut water fasting to deplete all PUFAs but it might be dangerous as other members said they got worse
Interesting...I've done a fast of just bone broth and occasional carrots and loved it, but n=1 of course.
 

Razvan

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I was thinking about doing a 31 days coconut water fasting to deplete all PUFAs but it might be dangerous as other members said they got worse
No. You will free up the pufas, will inhibit the thyroid and also making things even worse by not ingesting carbs.
Just take high amounts of vitamin E ,try to avoid pufas and starch and try to lower prolactin as much as you can,you will improve dopamine and you will lose safe amounts of weight with great metabolism without poisoning yourself with free fatty acids.
You could eat no-fat a period to help initially.
 

meatbag

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I was thinking about doing a 31 days coconut water fasting to deplete all PUFAs but it might be dangerous as other members said they got worse
If you can consume milk, skim milk, white sugar, coffee, orange juice, raw carrots, need extra salt baking soda, broth, cooked mushrooms are good. It works and it's totally worth it in my opinion, you will feel way way better. I got loaded up on pufa again awhile back and feel much better after doing the extremely low fat
 

Razvan

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Yes
If you can consume milk, skim milk, white sugar, coffee, orange juice, raw carrots, need extra salt baking soda, broth, cooked mushrooms are good. It works and it's totally worth it in my opinion, you will feel way way better. I got loaded up on pufa again awhile back and feel much better after doing the extremely low fat
Yes low fat can help ,but only for a period. Upping cholesterol after stopping low fat should give a lot of benefits.
 

baccheion

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Still wondering how this all interacts with apoE 4. Has anyone with apoE 4/3 mutation done the saturated fat Ray Peat diet? How'd it affect labs? OxLDL?
 
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