steroidogenesis

  1. fever257

    Next attempt to cure PFS.

    Hello, I'm inquiring about a hormonal issue engendered by an 8-9 month long course of finasteride. Around 2 years after taking finasteride, I took human chloronic gonadotropin(earlier this year) which increased my male hormones, but also massively spiked my estrogen, to the point where I have...
  2. cupofcoffee

    Growth hormone and thyroid hormones stimulate liver 5 alpha-reductase

    https://pubmed.ncbi.nlm.nih.gov/2172247/ not sure if this study was posted
  3. Mauritio

    The skin as a steroidogenic organ

    Here's a collection of studies on the skin as a steroidogenic organ mainly to show that hormones like pregnenolone have a different metabolization topically, compared to orally. "The cutaneous steroidogenic system can also have systemic effects, which are emphasized by significant skin...
  4. haidut

    Low energy production (glucose metabolism) may cause andropause

    As many of my readers know, aging men can also experience the equivalent of menopause and doctors informally call that state "andropause". Its official name is age-related hypogonadism and most of that hypogonadism is of the "secondary" type - i.e. the gonads appears to be in fine shape but for...
  5. haidut

    New Human Trial With An NAD Precursor

    I just wanted to post this here, as it seems interest in raising NAD is high among pharma companies. While nicotinamide riboside is the most popular precursor used in the Western world, nicotinamide mononucleotide (NMN) is another one that has been used clinically. This clinical trial below...
  6. haidut

    PUFA Inhibit Progesterone Production And Thus Drive/cause Menopause

    Peat wrote in a few of his articles that menopause is largely driven by a deficiency of progesterone and mentioned several anecdotes of women in their 50s and 60s getting their periods back after supplementing with large doses progesterone. In one of his articles he said that PUFA and estrogen...
  7. H

    Cholesterogenesis To Steroidogenesis: Role Of B2 In The Biosynthesis Of D

    Cholesterogenesis to Steroidogenesis: Role of B2 in the Biosynthesis of D From Cholesterogenesis to Steroidogenesis: Role of Riboflavin and Flavoenzymes in the Biosynthesis of Vitamin D From Cholesterogenesis to Steroidogenesis: Role of Riboflavin and Flavoenzymes in the Biosynthesis of...
  8. haidut

    Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

    I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...
  9. P

    Effect Of Various Salt Intake On Male Rats Fertility , T , FSH , LH

    Reproductive parameters and oxidative stress status of male rats fed with low and high salt diet Abstract BACKGROUND: Deficiency of minerals and micronutrients has been reported to impair the process of spermatogenesis. Historically, salt has been used by women on their husbands to increase...
  10. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
  11. haidut

    Nitrates / Nitrites Inhibit Androgen Synthesis By Raising NO

    Ray had a separate newsletter and a radio show on the dangers of NO precursors like dietary nitrates / nitrites and supplements like arginine. It is a bit ironic that quite a few bodybuilders out there pay a lot of money for the so-called NO boosters and in reality get the exact opposite effect...
  12. Dopamine

    Testicular Steroidogenesis Decreased By Heat (Problem With Hot Baths?)

    Testicular steroidogenesis is decreased by hyperthermia in old rats. - PubMed - NCBI "Hyperthermia significantly decreased the testicular testosterone level in old male rats and significantly lowered the StAR protein level. These data imply that frequent hot baths might impair testicular...
  13. haidut

    PPI Drugs (anti GERD) Powerfully Inhibit Steroidogenesis

    I have always been suspicious of PPI drugs. There are many reasons for it, including the falsified clinical trial data to conceal increased risk of gastric cancer, the idiotic premise that gastric acid increases with age, the kidney failure side effects, and the calcium/magnesium depletion being...
  14. haidut

    Recovering Steroidogenesis Inhibited By Alcohol And Drugs

    As many of you know, drugs like Finasteride are really bad not only because they cause a variety of CNS effects as a result of inhibiting 5-AR, but also because they systemically inhibit the entire steroid synthesis cascade. Toxins and alcohol do the same and currently there is no approved...
  15. Koveras

    Apigenin Increases Steroidogenesis

    "Previous studies reported that the age-related decline in testosterone biosynthesis is associated with a decrease in the steroidogenic acute regulatory (StAR) protein which regulates the rate-limiting step of testosterone biosynthesis. To explore the possibility of delaying this decline using a...
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