Niacinamide / Nicotinamide Has A Glycogen-sparing Effect

Discussion in 'Scientific Studies' started by haidut, Apr 10, 2014.

  1. haidut

    haidut Member

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    This may be one of its anti-stress mechanisms, in addition to its benzo similarities.

    http://www.ncbi.nlm.nih.gov/pubmed/2963642

    "...The inhibitory action of nicotinic acid, nicotinamide, N-nicotinoyl-gamma-aminobutyric acid, NAD, NADH, NADP, and NADPH on the rabbit skeletal muscle glycogen phosphorylase b has been studied. The inhibition is reversible and positively cooperative..."

    The enzyme "glycogen phosphorylase b" breaks down glycogen, and based on the above study niacin / niacinamide and their products NAD(P)(H) inhibit it in muscles, thus keeping glycogen levels high.
     
  2. Such_Saturation

    Such_Saturation Member

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    Do you think all the properties of this vitamin combined might make it unwise to take it without enough sugar?
     
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    haidut

    haidut Member

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    I have to say yes, and I suspect the same is true for thiamine (B1), biotin, and riboflavin (B2). Not sure about pyridoxine (B6).
     
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