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Ketotifen?

Discussion in 'Pharmaceutical Drugs' started by rw39, Nov 6, 2016.

  1. rw39

    rw39 Member

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    anyone know if this is good or bad? Have some mast cell and histamine problems---looking into using this and maybe cypro
     
  2. haidut

    haidut Member

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    Ketotifen has some good properties and the one I like the most is that it is an endotoxin (TLR4) antagonist:
    TLR4 - Wikipedia

    The issue with it is that it seems to raise NO in some studies but if you feel well on it and the doctor thinks it is OK then it is probably at least as good as cypro in terms of anti-allergy effects. I don't think it has anti-serotonin effects though.
     
  3. Sucrates

    Sucrates Member

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  4. haidut

    haidut Member

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    No, I had not seen it so thanks for sharing. It does seem like ketotifen may inhibit serotonin liberation from platelets, which would make it a functional serotonin antagonist, for a lack of better term. But the concentrations used were really high - 1mM / L, which would require ingesting grams of ketotifen per dose to reach that level. Obviously not something you want to do. I don't know if ketotifen has the same effect in the lower doses used clinically.
     
  5. Sucrates

    Sucrates Member

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    Yeah, it seems given that and the effect on NO ,that cypro would be a better choice. There are some other studies with ketotifen and anxiety, which is why I went digging for a link to serotonin.
     
  6. Waynish

    Waynish Member

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    Anyone find a good source to order from?
     
  7. HDD

    HDD Member

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  8. Mossy

    Mossy Member

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  9. thomas00

    thomas00 Member

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    I took it for a couple of months more than a year or so ago. The dose was the same as in the IBS study you can search for.

    It made me really cranky the first day. After that I didn't notice much. No side effects at all beyond that.

    Cypro has been better.

    If you're in Australia it's available from compounding pharmacies.
     
  10. Mossy

    Mossy Member

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    Thanks for sharing, thomas00.

    Yeah, I did see the thread about it helping poor digestion, which is my objective in taking it.

    When you say Cypro has been better, is that for the IBS/poor digestion, or just overall sense of well-being? Which reminds me, I did read in the other threads that ketotifen should help with PTSD.
     
  11. HDD

    HDD Member

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    I purchased it for someone else and he hasn’t taken any of it yet. Sorry I don’t have any feedback.
     
  12. Mossy

    Mossy Member

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    No problem. Thanks for responding.
     
  13. thomas00

    thomas00 Member

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    It's been more effective for IBS and mood. Ketotifen didn't seem to do much for either.
     
  14. Mossy

    Mossy Member

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    Ok, that helps, as I attempt to narrow down what to try. Thanks.
     
  15. debored13

    debored13 Member

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    tlr4 antagonists that are non toxic relatively are the main tho f I’m looking for right now. Me/cfs is chronic “low level” sepsis. Unfortunately LDN increases acth and even though it’s tlr4 antagonist it also is somewhat steroid like and increases blood pressure a lot sometimes.

    Do you really think that the NO increase from ketotifen would present problems ? I’ve heard nothing but good things about it so far. One person with mast cell issues that lead to hospitalization for anaphylaxis said high dose ketotifen was the only thing that kept him stable.
     
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