managing
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- Jun 19, 2014
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I have tried both cyproheptadine and ketotifen for managing (overheating, excessive sweating, high pulse, anxiety, etc) and found them to be surprisingly different, given their chemical similarity.
I've taken 500mcg of Cyproheptadine twice a day. The Ketotifen was less than 100mcg also twice/day. Harder to determine exact dose because I was using very small portions of 1mg tablets. I found that 500mcg of Ketotifen knocked me out thoroughly and left me with a "hungover feeling" the next day.
I would summarize the differences (for me) thusly:
-I found K to be much more anxiolytic than C
-I found C to cause more constipation
-I found K to be much more sedative than C, even at the smaller doses
-I found both K and C to decrease my appetite unexpectedly, although K was a stronger affect than C
-I experienced low blood sugar/aggressive episodes on C around its 8 hr half life during daytime
-I note a slight improvement in hearing with both C and K, with K perhaps being greater than C (i have an unexplained moderate to severe hearing loss)
The last two were rather surprising.
This study: Effect of Ketotifen and Cyproheptadine on Appetite and Weight Changes in Mice noted that varying doses of each resulted in significant weight gain OR loss. Hard to rationalize from murine doses, but perhaps the lower end dosages are analgous to the doses I've used. They even used a combination of both K and C (and found weight loss at the only combined dose they tried).
Secondarily, the only notable difference I can find between the known actions of the two is that K is a phosphodiesterase inhibitor (and thus, I would presume, enhances cAMP production). I wonder if this explains anything about why I react differently to the two. Particularly in regard to anxiolytic and hearing effects.
Which makes me wonder if the acid sphingomyelinase inhibition of something like Clemastine could be even better?
I've taken 500mcg of Cyproheptadine twice a day. The Ketotifen was less than 100mcg also twice/day. Harder to determine exact dose because I was using very small portions of 1mg tablets. I found that 500mcg of Ketotifen knocked me out thoroughly and left me with a "hungover feeling" the next day.
I would summarize the differences (for me) thusly:
-I found K to be much more anxiolytic than C
-I found C to cause more constipation
-I found K to be much more sedative than C, even at the smaller doses
-I found both K and C to decrease my appetite unexpectedly, although K was a stronger affect than C
-I experienced low blood sugar/aggressive episodes on C around its 8 hr half life during daytime
-I note a slight improvement in hearing with both C and K, with K perhaps being greater than C (i have an unexplained moderate to severe hearing loss)
The last two were rather surprising.
This study: Effect of Ketotifen and Cyproheptadine on Appetite and Weight Changes in Mice noted that varying doses of each resulted in significant weight gain OR loss. Hard to rationalize from murine doses, but perhaps the lower end dosages are analgous to the doses I've used. They even used a combination of both K and C (and found weight loss at the only combined dose they tried).
Secondarily, the only notable difference I can find between the known actions of the two is that K is a phosphodiesterase inhibitor (and thus, I would presume, enhances cAMP production). I wonder if this explains anything about why I react differently to the two. Particularly in regard to anxiolytic and hearing effects.
Which makes me wonder if the acid sphingomyelinase inhibition of something like Clemastine could be even better?
